Abstract:
:Two principal oblique factors are identified in the Bass Social Acquiescence Scale, a measure previously shown to correlate positively with placebo response and negatively with anxiolytic drug response. The two factors appeared very similar in separate analyses of data from samples of 941 psychiatric outpatients and 1,837 college students. Also, results are presented which indicate that one factor, tentatively labeled "traditionalism", accounted for the empirically observed relationships to placebo and drug response in two clinical trials.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
McNair DM,Barrett JEdoi
10.1007/BF00433044subject
Has Abstractpub_date
1979-10-01 00:00:00pages
165-70issue
2eissn
0033-3158issn
1432-2072journal_volume
65pub_type
杂志文章abstract::The effects of intraperitoneal administrations of the deoxycorticosterone metabolite, 5 alpha-pregnane-, 21 diol-20-one (3 alpha, 5 alpha-tetrahydrodeoxycorticosterone; alpha-THDOC) on the responses to aggression and defeat-induced analgesia were examined in subordinate intruder male mice in "resident-intruder" pairin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172960
更新日期:1988-01-01 00:00:00
abstract::Clonidine is a clinically used antihypertensive which has been suggested to produce physiological changes in children after exposure in utero. The aim of our study was to test the hypothesis that chronic exposure of the developing brain to an alpha 2-adrenergic agonist like clonidine would influence the adult neuroche...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02253583
更新日期:1992-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Drug-associated memories are hypothesized to underlie the high risk of relapse in addiction. Recent studies show that post-retrieval extinction training erases fear memories by reconsolidation blockade. Here, we examine the efficacy of this non-invasive procedure in rats with drug-associated mem...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2545-4
更新日期:2012-05-01 00:00:00
abstract::The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatments were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg of de...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00571413
更新日期:1978-01-31 00:00:00
abstract::In a double-blind comparison of haloperidol decanoate and fluphenazine decanoate given 4-weekly for 60 weeks as maintenance therapy in 38 chronic schizophrenic in-patients, plasma haloperidol, fluphenazine and prolactin levels were measured at regular intervals by radioimmunoassay. After the first injection, the mean ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244140
更新日期:1990-01-01 00:00:00
abstract::The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 microgram...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00470593
更新日期:1982-01-01 00:00:00
abstract::The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally stimulated b...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02249415
更新日期:1996-05-01 00:00:00
abstract:RATIONALE:Virtually all cocaine self-administration studies have used a "unit dose" as a reinforcing stimulus; the subject is a passive recipient of an experimenter-selected dose. OBJECTIVES:The present experiments examined the consequence of requiring the subject to actively determine the dose and speed of each injec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05565-1
更新日期:2020-09-01 00:00:00
abstract::Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431812
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:A positive relationship exists between chronic ethanol intoxication experiences and the severity of neural hyperactivity and withdrawal seizures. An important possibility is that withdrawal reactions also influence the motivation to obtain and consume ethanol. OBJECTIVES:To test this hypothesis, the effects ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1380-z
更新日期:2003-07-01 00:00:00
abstract:RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injectio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1861-3
更新日期:2004-10-01 00:00:00
abstract:RATIONALE:Noncontingent administration of amphetamine into the ventral striatum or systemic nicotine increases responses rewarded by inconsequential visual stimuli. When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABA(B) receptor agonis...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2450-x
更新日期:2012-03-01 00:00:00
abstract::Effects of two dosages of rubidium chloride on exploration, locomotion, rearing and immobility were assessed for male and female rats in an exploration box and an open field. In contrast to previous findings, rubidium was found to decrease locomotion and rearing in the exploratory box, and also to decrease locomotion ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426740
更新日期:1979-03-22 00:00:00
abstract::An experiment was conducted to test whether centrally acting drugs could act as conditioned stimuli (CS) in a classical conditioning paradigm in which electric shock acted as the unconditioned stimulus (US) and suppression of drinking was used as an indicator of a conditioned response (CR). Thirsty rats were allowed t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244921
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:We test methods to advance (shift earlier) circadian rhythms without producing misalignment between rhythms and sleep. We previously tested (1) a gradually advancing sleep/dark schedule plus morning bright light and afternoon/evening melatonin and (2) the same sleep schedule with only morning bright light. No...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2869-8
更新日期:2013-02-01 00:00:00
abstract::Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244285
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND AND RATIONALE:Nicotinic acetylcholine systems play major roles in cognitive function. Nicotine and a variety of nicotinic agonists improve attention, and nicotinic antagonist exposure impairs it. This study was conducted to investigate the effect of a novel nicotinic receptor agonist at α4β2 nicotinic recept...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2712-2
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Non-medical use of prescription opioids such as the mu opioid receptor (MOP-r) agonist oxycodone is a growing problem in the USA and elsewhere. There is limited information about oxycodone's impact on diverse gene systems in the brain. OBJECTIVES:The current study was designed to examine how chronic oxyco...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4657-y
更新日期:2017-08-01 00:00:00
abstract:RATIONALE:Previous studies have postulated functional links between GABA and cannabinoid systems in the hippocampus. The aim of the present study was to investigate any possible interaction between these systems in spatial change and object novelty discrimination memory consolidation in the dorsal hippocampus (CA1 regi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4688-4
更新日期:2017-10-01 00:00:00
abstract::Mice ran in a circular runway. Some received milk at every third circuit in a designated direction, clockwise or counterclockwise, in daily 1000-s sessions. Under control conditions, about 10 times as many circuits were made in the reinforced direction as in the non-reinforced direction. Cocaine (10, 30, 100 microM/kg...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244125
更新日期:1990-01-01 00:00:00
abstract::Twelve healthy chronic schizophrenic patients were treated with the long-acting oral dopamine (DA) receptor blocker penfluridol (100 mg orally) for 6 weeks. Plasma prolactin (PRL) levels were measured during insulin-tolerance tests (ITT) performed at the end of the drug-free period (7-10 days) and during weeks 1 and 6...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427494
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularl...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3840-7
更新日期:2015-06-01 00:00:00
abstract:AIM:It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin re...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4664-z
更新日期:2017-08-01 00:00:00
abstract::The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172869
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and, mo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000550
更新日期:2001-01-01 00:00:00
abstract::A neutral stimulus can acquire conditioned rewarding properties through association with an intrinsically rewarding stimulus. The acquisition of responding for conditioned rewards requires that environmental stimuli and reward processes interact in a highly specific manner; analyses of this phenomenon may provide valu...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050982
更新日期:1999-05-01 00:00:00
abstract:RATIONALE:Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0176-3
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. METHODS:A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This w...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1619-z
更新日期:2009-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Footshock stress reliably reinstates heroin seeking in rats, but the time course of the development of this effect following drug withdrawal is not known. Here we studied the effect of intermittent footshock stress on reinstatement of heroin seeking following different withdrawal periods (1-66 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100748
更新日期:2001-06-01 00:00:00
abstract:RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as thes...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0992-8
更新日期:2008-03-01 00:00:00