Abstract:
RATIONALE:Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for language. METHODS:To test this hypothesis, language activation was measured twice with functional magnetic resonance imaging in ten healthy right-handed men in a double-blind crossover design 2 h after amphetamine or placebo administration. RESULTS:Language-related activation increased significantly in task-related areas, but the individual lateralization index was not affected in the amphetamine condition as compared to placebo. CONCLUSIONS:This finding suggests that short-termed alterations in the dopaminergic neurotransmission do not affect language dominance.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Sommer IE,Oranje B,Ramsey NF,Klerk FA,Mandl RC,Westenberg HG,Kahn RSdoi
10.1007/s00213-005-0176-3subject
Has Abstractpub_date
2006-01-01 00:00:00pages
387-93issue
4eissn
0033-3158issn
1432-2072journal_volume
183pub_type
杂志文章,随机对照试验abstract::The current study examined whether stimuli predictive of heroin availability were capable of inducing a relapse of drug-seeking behavior in an operant runway task. Olfactory stimuli (orange and almond food extract) served as discriminative cues about the availability (S+) or unavailability (S-) of heroin reinforcement...
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pub_type: 临床试验,杂志文章,随机对照试验
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