EEG effects of i.v. infusion of pentylenetetrazol in rats: a model for screening and classifying antiepileptic compounds.

abstract：RATIONALE:Prepulse inhibition (PPI) and locomotor activity have been used to investigate the effects of antipsychotic and stimulant drugs and their underlying dopaminergic mechanisms. Whereas D2-like agonists consistently decreased PPI and increased locomotion in rats in previous studies, we recently reported that thes...

journal_title：Psychopharmacology

authors： Ralph RJ,Caine SB

更新日期：2007-04-01 00:00:00

abstract：:Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...

journal_title：Psychopharmacology

authors： Smith JB,McKearney JW

更新日期：1977-07-18 00:00:00

abstract：:Seven neuroleptic-free schizophrenic patients received bromocriptine and eight schizophrenic patients received CF 25-397, both ergot derivatives with dopamine agonist activity. Psychosis failed to improve in response to either drug at the relatively low doses administered. Unlike the antipsychotic property of apomorph...

journal_title：Psychopharmacology

authors： Tamminga CA,Schaffer MH

更新日期：1979-01-01 00:00:00

abstract：:The discriminative stimulus effect of midazolam, a short-acting benzodiazepine, was used for testing the effects of drugs thought to act as antagonists at different sites in the proposed benzodiazepine receptor complex. Rats were trained in a standard two-bar operant conditioning procedure with food reinforcers delive...

journal_title：Psychopharmacology

authors： Stolerman IP,Garcha HS,Rose IC

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Although newer interview methods such as Structured Interview Guide for the Montgomery-Asberg Depression Rating Scale (SIGMA; MADRS) with audiotaping and Rater Applied Performance Scale (RAPS) appraisal have been introduced to improve reliability of ratings in antidepressant clinical trials, there is limited ...

journal_title：Psychopharmacology

authors： Khan A,Faucett J,Brown WA

更新日期：2014-11-01 00:00:00

abstract：RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...

journal_title：Psychopharmacology

authors： Gagliano H,Ortega-Sanchez JA,Nadal R,Armario A

更新日期：2017-10-01 00:00:00

abstract：:The effects of benztropine, scopolamine, atropine, methylatropine, amitriptyline, phencyclidine, and meperidine were determined alone and in conjunction with a behaviorally suppressing dose (0.05 mg/kg IM) of oxotremorine in pigeons responding under a multiple fixed-ratio 30 fixed-interval 5-min schedule of grain pres...

journal_title：Psychopharmacology

authors： Leander JD

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Arcaine is a competitive antagonist of the polyamine binding site at the N-methyl-D-aspartic acid receptor which induces state-dependent recall. However, no study has addressed the involvement of other neurotransmitter/neuromodulators in arcaine-induced state dependency. OBJECTIVES:The current study investig...

journal_title：Psychopharmacology

authors： Mariani RK,Mello CF,Rosa MM,Ceretta AP,Camera K,Rubin MA

更新日期：2011-06-01 00:00:00

abstract：RATIONALE:Drug-associated environmental stimuli may serve as conditioned reinforcers to enhance drug self-administration behaviors in humans and laboratory animals. However, it can be difficult to distinguish experimentally the conditioned reinforcing effects of a stimulus from other behavioral processes that can chang...

journal_title：Psychopharmacology

authors： Bertz JW,Woods JH

更新日期：2013-09-01 00:00:00

abstract：RATIONALE:Intermittent social defeat stress can induce neuroadaptations that promote compulsive drug taking. Within the mesocorticolimbic circuit, repeated cocaine administration activates extracellular signal-regulated kinase (ERK). OBJECTIVE:The present experiments examine whether changes in ERK phosphorylation are ...

journal_title：Psychopharmacology

authors： Yap JJ,Chartoff EH,Holly EN,Potter DN,Carlezon WA Jr,Miczek KA

更新日期：2015-05-01 00:00:00

abstract：:Spontaneous and amphetamine-elicited locomotor activity in rats is reduced by most clinically effective antipsychotic drugs. We have recently demonstrated that intracerebroventricular infusion of kainic acid (KA), which produces cell loss in the hippocampus and other limbic-cortical brain regions, increases spontaneou...

journal_title：Psychopharmacology

authors： Bardgett ME,Jackson JL,Taylor BM,Csernansky JG

更新日期：1998-02-01 00:00:00

abstract：:Serotonergic mechanisms have been implicated in the pathophysiology of depression and in the neuropharmacology of antidepressant treatment. One measure of central serotonergic function is the prolactin (PRL) response to IV L-tryptophan (L-TRP). We used the L-TRP test to assess the role of serotonin in the mechanism of...

journal_title：Psychopharmacology

authors： McCance-Katz E,Price LH,Charney DS,Heninger GR

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists (e.g., selective 5-HT reuptake inhibitors [SSRI]) stimulate multiple 5-HT receptors, although the role of particular receptors as well as interaction(s) among different receptors in the therapeutic effects of SSRIs is not fully understood. OBJECTIVES:Relativ...

journal_title：Psychopharmacology

authors： Li JX,Crocker C,Koek W,Rice KC,France CP

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:Intramuscular (IM) conventional antipsychotics and/or benzodiazepines are effective in the short-term treatment of acutely agitated psychotic patients but may be associated with adverse effects. A short-acting IM formulation of the novel antipsychotic, ziprasidone, which may offer advantages over conventional...

journal_title：Psychopharmacology

authors： Daniel DG,Potkin SG,Reeves KR,Swift RH,Harrigan EP

更新日期：2001-05-01 00:00:00

abstract：RATIONALE:The effects of caffeine, especially caffeinated coffee, on human performance have been extensively studied. However, few studies have been naturalistic representations of how tea/coffee is normally consumed in terms of dose and time of consumption. OBJECTIVES:This study investigated the effects of day-long c...

journal_title：Psychopharmacology

authors： Hindmarch I,Rigney U,Stanley N,Quinlan P,Rycroft J,Lane J

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:Caffeine and the adenosine A(1) and A(2A) receptor antagonist CGS15943 produce many behavioral effects that are similar to those produced by classic stimulant drugs (e.g. cocaine and amphetamines). OBJECTIVES:The current study evaluated whether CGS15943 would maintain self-administration and reinstate exting...

journal_title：Psychopharmacology

authors： Weerts EM,Griffiths RR

更新日期：2003-07-01 00:00:00

abstract：:The behavioral consequences of prolonged continuous exposure to cocaine were examined in rhesus monkeys. Operant behavior was sampled for 0.5 h every 6 h, and cocaine was continuously infused through an intravenous catheter. Cocaine (4.0-32 mg/kg/day) initially caused reductions in the rate of responding for food and ...

journal_title：Psychopharmacology

authors： Woolverton WL,Kleven MS

更新日期：1988-01-01 00:00:00

abstract：:In order to study experimental alcohol intake that leads to heightened aggression, we established ethanol self-administration in aggressive rats. The focus was on low doses of self-administered ethanol and to assess their effects on aggressive behavior in resident rats, using a limited access paradigm followed by a 5-...

journal_title：Psychopharmacology

authors： van Erp AM,Miczek KA

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Synthesis of ligands inactive or with low activity at α₁ GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) α₁-subtype selective partial positive modulator, may serve as a pharmacological tool for refining the ro...

journal_title：Psychopharmacology

authors： Joksimović S,Varagic Z,Kovačević J,Van Linn M,Milić M,Rallapalli S,Timić T,Sieghart W,Cook JM,Savić MM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Several theories propose alternative explanations for drug addiction. OBJECTIVES:We propose a general theory of transition to addiction that synthesizes knowledge generated in the field of addiction into a unitary explanatory frame. MAJOR PRINCIPLES OF THE THEORY:Transition to addiction results from a sequ...

journal_title：Psychopharmacology

authors： Piazza PV,Deroche-Gamonet V

更新日期：2013-10-01 00:00:00

abstract：RATIONALE:Traditional remedies prepared from Ptychopetalum olacoides (PO) are used throughout the Amazon to alleviate age-related conditions. These formulas are mainly used by elders, and alleged effects may be related to the anticholinesterase properties identified in a standardized ethanol extract of this species [P....

journal_title：Psychopharmacology

authors： da Silva AL,Silva Martins Bd,Linck Vde M,Herrmann AP,Mai N,Nunes DS,Elisabetsky E

更新日期：2009-01-01 00:00:00

abstract：:The relationship between nicotine yield as determined by the FTC method and nicotine absorption was examined in 72 smokers in a more rigorous repetition of a previous study of 33 smokers. For this study, 113 smokers evenly distributed across four FTC "tar" yield ranges were recruited, only 72 demonstrated reasonable c...

journal_title：Psychopharmacology

authors： Byrd GD,Davis RA,Caldwell WS,Robinson JH,deBethizy JD

更新日期：1998-10-01 00:00:00

abstract：:Three recently arrived drug naive Cebus apella monkeys with "spontaneous" stereotyped oral movements were treated with apomorphine and haloperidol using a wide dose range. Low doses of apomorphine (0.05-0.1 mg/kg) suppressed the oral stereotypies without affecting normal behaviour such as grooming and scratching. High...

journal_title：Psychopharmacology

authors： Korsgaard S,Povlsen UJ,Randrup A

更新日期：1985-01-01 00:00:00

abstract：:Twelve healthy chronic schizophrenic patients were treated with the long-acting oral dopamine (DA) receptor blocker penfluridol (100 mg orally) for 6 weeks. Plasma prolactin (PRL) levels were measured during insulin-tolerance tests (ITT) performed at the end of the drug-free period (7-10 days) and during weeks 1 and 6...

journal_title：Psychopharmacology

authors： Nathan RS,Sachar EJ,Ostrow L,Asnis GM,Halbreich U,Halpern F,Renzi NL,Slotnick V

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Feldon J

更新日期：2011-03-01 00:00:00

abstract：:A review and meta-analysis by Hamer et al. (2006) showed that a single session of exercise can attenuate post-exercise blood pressure (BP) responses to stress, but no studies examined the effects among smokers or with brisk walking. Healthy volunteers (n=60), averaging 28 years of age and smoking 15 cigarettes daily, ...

journal_title：Psychopharmacology

authors： Taylor A,Katomeri M

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:Ayahuasca is a traditional South American psychoactive beverage and the central sacrament of Brazilian-based religious groups, with followers in Europe and the United States. The tea contains the psychedelic indole N,N-dimethyltryptamine (DMT) and beta-carboline alkaloids with monoamine oxidase-inhibiting pr...

journal_title：Psychopharmacology

authors： Barbanoj MJ,Riba J,Clos S,Giménez S,Grasa E,Romero S

更新日期：2008-02-01 00:00:00

abstract：:Red blood cell (RBC) glycine levels were examined in 27 bipolar patients, treated with lithium carbonate for a minimum of 8 months, who were either hypomanic, depressed, or euthymic in their mood. We found no difference in the RBC glycine or in the RBC: plasma glycine ratio between the hypomanic, depressed, or euthymi...

journal_title：Psychopharmacology

authors： Peselow ED,Deutsch SI,Stanley M,Banay-Schwartz M,Virgilio J,Fieve RR

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:There is a close relationship between arousal and pupil diameter, decrease in the level of arousal being accompanied by constriction of the pupil (miosis), probably reflecting the attenuation of sympathetic outflow as sedation sets in. Paradoxically, sedation induced by benzodiazepines is not accompanied by m...

journal_title：Psychopharmacology

authors： Hou RH,Samuels ER,Langley RW,Szabadi E,Bradshaw CM

更新日期：2007-11-01 00:00:00

abstract：RATIONALE:Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. OBJECTIVES:This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kav...

journal_title：Psychopharmacology

authors： Smith KK,Dharmaratne HR,Feltenstein MW,Broom SL,Roach JT,Nanayakkara NP,Khan IA,Sufka KJ

更新日期：2001-04-01 00:00:00