Abstract：
:Serotonergic mechanisms have been implicated in the pathophysiology of depression and in the neuropharmacology of antidepressant treatment. One measure of central serotonergic function is the prolactin (PRL) response to IV L-tryptophan (L-TRP). We used the L-TRP test to assess the role of serotonin in the mechanism of action of lithium augmentation in refractory major depression. Twenty-six patients with antidepressant-refractory major depression each received three L-TRP tests (after 2 weeks of placebo, after 4 weeks of active primary antidepressant, and after 1 week of lithium augmentation). Primary antidepressant treatment did not increase the PRL response, but lithium augmentation resulted in a statistically significant increase in PRL response as compared to both placebo pretreatment (P less than 0.04) and antidepressant treatment alone (P less than 0.025). This study supports a role for serotonergic mechanisms in the action of lithium augmentation.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
McCance-Katz E,Price LH,Charney DS,Heninger GRdoi
10.1007/BF02245291subject
Has Abstractpub_date
1992-01-01 00:00:00pages
93-7issue
1-2eissn
0033-3158issn
1432-2072journal_volume
108pub_type
杂志文章abstract：:Twenty-one (three groups of seven), men and women, 25-50 years of age were studied to determine whether or not rebound insomnia would increase the likelihood of self administering a benzodiazepine (triazolam 0.25 mg) hypnotic. The groups compared were patients with insomnia and disturbed sleep, insomnia and normal sle...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245259
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are gut derived hormones. GLP-1 and GLP-2 were shown to have pleiotropic effects in intestinal and pancreatic diseases. OBJECTIVE:We aimed to investigate the activities of GLP-1 and GLP-2 on nociception and inflammation in mice, involving th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5154-7
更新日期：2019-06-01 00:00:00
abstract：RATIONALE:Alcohol-associated cues elicit craving in human addicts but little is known about craving mechanisms. Current animal models focus on relapse and this may confound the effect of environmental cues. OBJECTIVES. To develop a model to study the effects of environmental cues on alcohol consumption in animals not e...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1454-6
更新日期：2003-07-01 00:00:00
abstract：:Two studies were conducted to replicate and extend previous demonstrations of smoking-induced, dose-related reports of euphoria, and to confirm this relationship using measures of plasma nicotine. In experiment 1, overnight-deprived subjects, in three different sessions, smoked ultralow-, high-nicotine, and usual-bran...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02247422
更新日期：1992-01-01 00:00:00
abstract：:Latent inhibition (LI) is a phenomenon in which repeated, non-reinforced presentation of a stimulus retards subsequent conditioning to that stimulus. Several recent experiments have suggested that LI is abolished following acute, low doses of amphetamine given during pre-exposure and conditioning, and this effect has ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244656
更新日期：1993-01-01 00:00:00
abstract：:Ethanol-induced locomotor stimulation has been proposed to be positively correlated with the rewarding effects of ethanol (Wise and Bozarth 1987). The present experiments provided a test of this hypothesis using a genetic model. Three behavioral indices of the motivational effects of ethanol (drinking, taste condition...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245064
更新日期：1994-10-01 00:00:00
abstract：RATIONALE:Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function. OBJECTIVE:The aim of this study was to investigate these alterations during a perturbed homeostatic state. METHODS:Fifteen patients with schizophrenia and 13...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1890-y
更新日期：2004-11-01 00:00:00
abstract：:Self-injection of phencyclidine HCI (PCP) and four of its analogues was examined in baboons. IV injections of drug were dependent upon completion of 160 lever presses (a 160-response fixed-ratio schedule). A 3-h time-out period followed each injection, permitting a maximum of eight injections per day. Self-injection p...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428537
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear. OBJECTIVE:The present study examined the effect of pharmacological activation or blockade of the cannabinoid CB1 receptors on behavioral flexibility usi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0421-4
更新日期：2006-08-01 00:00:00
abstract：:Several behaviors associated with the serotonin syndrome have been reported in rats following administration of the 5-HT1A receptor agonist 8-OH-DPAT. The present investigation approached this phenomenon from an ethopharmacological perspective, and provided a detailed temporal analysis of the behavioral effects of thi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247363
更新日期：1993-01-01 00:00:00
abstract：:The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442567
更新日期：1989-01-01 00:00:00
abstract：:The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050563
更新日期：1998-04-01 00:00:00
abstract：RATIONALE:Certain disorders, such as depression and anxiety, to which serotonin dysfunction is historically associated, are also associated with lower assessments of other people's trustworthiness. Serotonergic changes are known to alter cognitive responses to threatening stimuli. This effect may manifest socially as r...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-014-3444-2
更新日期：2014-07-01 00:00:00
abstract：:Antipsychotic drugs, such as haloperidol and risperidone, are used in long-term treatment of psychiatric patients and thus increase the risk of obesity and other metabolic dysfunctions. Available evidence suggests that these drugs have pro-inflammatory effect, which contributes to the establishment of endocrine distur...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4079-7
更新日期：2016-05-01 00:00:00
abstract：RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05462-7
更新日期：2020-05-01 00:00:00
abstract：:A new benzamide, cis-N-(1-benzyl-2-methylpyrrolidin - 3 - yl) - 5 - chloro - 2 - methoxy - 4 - methylaminobenzamide (YM-09151-2) exhibited more potent and longer-lasting inhibitory effects on apomorphine-induced behaviours (stereotyped behaviour, emesis and hypothermia), and methamphetamine-induced stereotyped behavio...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00429198
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIV...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-4913-9
更新日期：2018-07-01 00:00:00
abstract：INTRODUCTION:Casein kinase I epsilon/delta phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional/translational feedback loops that comprise the circadian oscillator in mammals. Pharmacologic inhibition leads to a delay of the oscillations with the magnitude of this effect dep...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1860-5
更新日期：2010-07-01 00:00:00
abstract：RATIONALE:Clinically, nicotine improves attention, but this has proven difficult to demonstrate preclinically. We tested nicotine in Sprague-Dawley (SD) and Lister hooded (LH) rats in the five-choice serial reaction time task. Since SD rats demonstrate lower asymptotic performance than LH rats, we surmised that nicotin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000605
更新日期：2001-02-01 00:00:00
abstract：:The suggestions that dopamine (DA) systems are involved in "motor control" and "reward" represent the classic working hypotheses on the behavioral functions of these systems. The research generated by these hypotheses has yielded results that are far more complicated than the simplest form of either hypothesis would i...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02245133
更新日期：1992-01-01 00:00:00
abstract：:The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244001
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis. OBJECTIVES:The present study investigates whether event-related potentials (ERPs) differ between occasional and heavy cannabis users after acute Δ9-tetrahydrocannabinol (THC) administration, as a result of to...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2479-x
更新日期：2012-03-01 00:00:00
abstract：RATIONALE:The present series of experiments was conducted in order to assess the nature of dopaminergic modulation of the acoustic startle response using agonists and antagonists specific for dopamine D1 and D2 receptors. OBJECTIVES:The objective of the present study was to demonstrate an enhancement of the acoustic s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051020
更新日期：1999-06-01 00:00:00
abstract：RATIONALE:Serotonin 5-HT2A and 5-HT2C receptors are thought to be the primary pharmacological mechanisms for serotonin-mediated hallucinogenic drugs, but recently there has been interest in metabotropic glutamate (mGluR2) receptors as contributors to the mechanism of hallucinogens. OBJECTIVE:The present study assesses...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3658-3
更新日期：2015-01-01 00:00:00
abstract：RATIONALE:A glutamate-dopamine interaction has been implicated in the psychosis-like effects of glutamate N-methyl- D-aspartate (NMDA) receptor antagonists, such as phencyclidine and ketamine. However, recent imaging studies addressing striatal glutamate-dopamine interaction directly in vivo in man have been controvers...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1236-6
更新日期：2002-12-01 00:00:00
abstract：:The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00445554
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1326-5
更新日期：2003-09-01 00:00:00
abstract：:The effects of an "aggression"-reducing drug, fluprazine, and an "aggression"-enhancing drug, ethanol, were evaluated in mice using the target biting and resident-intruder paradigms. Under baseline conditions there was a high target biting rate immediately after the delivery of a 2.0 mA tail shock, an intermediate tar...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00217061
更新日期：1987-01-01 00:00:00
abstract：RATIONALE:Antiepileptic drugs are known to produce side effects which may impair driving performance. Performance effects, however, may differ substantially between individual antiepileptic drugs. OBJECTIVE:To compare the effects of carbamazepine, remacemide, and placebo on actual driving performance during a 12-day i...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130100898
更新日期：2002-01-01 00:00:00
abstract：:The effects of naltrexone methobromide, a quaternary derivative of the opioid antagonist naltrexone, were investigated on deprivation (24 h)-induced water intake in the unilaterally cannulated rats. Naltrexone methobromide reduced post-deprivational water intake with an ED50 of 7.3 micrograms when tested at 30 min (pe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00518177
更新日期：1987-01-01 00:00:00
