Abstract:
:Seven neuroleptic-free schizophrenic patients received bromocriptine and eight schizophrenic patients received CF 25-397, both ergot derivatives with dopamine agonist activity. Psychosis failed to improve in response to either drug at the relatively low doses administered. Unlike the antipsychotic property of apomorphine at low dose levels, neither of these ergot drugs improved schizophrenic symptomatology.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Tamminga CA,Schaffer MHdoi
10.1007/BF00428312subject
Has Abstractpub_date
1979-01-01 00:00:00pages
239-42issue
3eissn
0033-3158issn
1432-2072journal_volume
66pub_type
临床试验,杂志文章,随机对照试验abstract::Two enantiomers (1S and 1R) of delta-3-tetrahydrocannabinol were assayed in man for psychoactivity. The 1S enantiomer had definite psychic actions, qualitatively similar to those of delta-1-tetrahydrocannabinol, but quantitatively less potent (1:3 to 1:6). Adding the two enantiomers together did not increase the effec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00176485
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Convulsions associated with cocaine toxicity are a serious aspect of cocaine-related emergency room incidents. Seizures can result from a single high dose of cocaine, and evidence is accumulating that correlates repetitive administration of sub-convulsive doses of cocaine with a decreased seizure threshold, a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050027
更新日期:2000-01-01 00:00:00
abstract::This study examined and compared withdrawal signs and symptoms from cessation of 0, 2 and 4 mg nicotine gum. In addition, a comparison was made between nicotine gum versus cigarette withdrawal symptoms. Smokers first underwent cigarette deprivation for 4 days and then were randomly assigned to 0 (N = 16), 2 (N = 25), ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245656
更新日期:1991-01-01 00:00:00
abstract::Effects of chlordiazepoxide (CDP) and ethanolamine-O-sulphate (EOS) alone and in combination were tested on the acquisition and performance of continuous reinforcement - time out (CR-TO) and variable interval reinforcement - time out (VI-TO) operant discriminations in rats. CDP disrupted acquisition of CR-TO discrimin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310620
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Control of reward-seeking behavior under conditions of punishment is an important function for survival. OBJECTIVES AND METHODS:We designed a task in which rats could choose to either press a lever and obtain a food pellet accompanied by a footshock or refrain from pressing the lever to avoid footshock, in r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05398-7
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-012-2684-2
更新日期:2012-09-01 00:00:00
abstract:RATIONALE:Acute ethanol administration induces hypothermia in genetically susceptible animals. Tolerance to this effect may develop with repeated administration. Allopregnanolone is an endogenously produced neuroactive steroid that acts at the GABA-A receptor. We postulated that allopregnanolone would induce hypothermi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1106-2
更新日期:2002-07-01 00:00:00
abstract:RATIONALE:When paired with training, substances that increase monoaminergic transmission in the brain support motor and language learning in healthy subjects and in rehabilitation after brain lesions. OBJECTIVES:To test the hypotheses that enhancement of central norepinephrine by the selective norepinephrine reuptake ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0420-5
更新日期:2006-08-01 00:00:00
abstract:RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0805-0
更新日期:2007-09-01 00:00:00
abstract::Diazepam-sensitive (DS) and -resistant (DR) mice were selectively bred for increased and reduced sensitivity to the ataxic effects of diazepam (40 mg/kg). Other response differences between DS and DR mice may reflect pleiotropic effects of the genes fixed during their selection. These mice were tested for their sensit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244976
更新日期:1992-01-01 00:00:00
abstract::The effects of flumazenil, a benzodiazepine receptor antagonist, on triazolam- and zolpidem-induced memory impairment were investigated. Sixty subjects received oral triazolam 0.5 mg, zolpidem 20.0 mg, or placebo at 10 a.m. (n = 20 per drug). Ninety minutes later, half of the subjects (n = 10) in each oral drug group ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02245635
更新日期:1995-09-01 00:00:00
abstract::Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427324
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction. OBJ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1193-0
更新日期:2003-07-01 00:00:00
abstract:RATIONALE:Major depression is a chronic disabling disorder, often preceded by stress. Despite emerging clinical interest in mechanisms perpetuating episodes of depression and/or establishing increased vulnerability for relapse, little attention has been paid to address these aspects in experimental models. Here, we stu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1835-6
更新日期:2010-06-01 00:00:00
abstract::In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucle...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429665
更新日期:1985-01-01 00:00:00
abstract::A number of clinically used benzodiazepines were tested for their effectiveness in blocking muscimol-induced myoclonic jerks in mice. Their ED50 values were determined from their dose-response curves. These data gave the following relative potencies with respect to diazepam: diazepam = 1, medazepam = 0.24, oxazepam = ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432441
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-3423-z
更新日期:2014-09-01 00:00:00
abstract:RATIONALE:Fluoxetine improves affect in clinical syndromes such as depression and premenstrual dysphoric disorder. Little is known about fluoxetine's influence on mood changes after quitting smoking, which often resemble sub-clinical depression. OBJECTIVES:The present study, a re-analysis of previously published data ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00213-003-1711-8
更新日期:2004-04-01 00:00:00
abstract::The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172869
更新日期:1986-01-01 00:00:00
abstract::Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050852
更新日期:1999-02-01 00:00:00
abstract:RATIONALE:Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05623-8
更新日期:2020-11-01 00:00:00
abstract::Established social groups of talapoin monkeys show rank-related differences in aggressive, social and sexual behaviours and visual monitoring, as well as in endocrine and monoamine profiles. Here we describe the effects on these variables of an "anxiogenic drug", beta-carboline carboxylic acid ethyl ester (beta-CCE), ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179193
更新日期:1986-01-01 00:00:00
abstract::The effects of acutely or chronically administered carbamazepine were studied in rats submitted to the modified Geller-Seifter conflict test. Diazepam was used as a standard anxiolytic. The results showed an increase in punished response after carbamazepine, as observed with diazepam, leading to the suggestion of an a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244411
更新日期:1990-01-01 00:00:00
abstract::Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anx...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00187246
更新日期:1987-01-01 00:00:00
abstract::Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439445
更新日期:1989-01-01 00:00:00
abstract::Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429014
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION:Prior activation of the kappa opioid system by repeated stress or agonist administration has been previously shown to potentiate the rewarding properties of subsequently administered cocaine. In the present study, intermittent and uncontrollable footshock, a single session of forced swim, or acute administ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1122-y
更新日期:2008-09-01 00:00:00
abstract:RATIONALE:A substantial portion of cigarette smokers prefer menthol-flavored cigarettes. To date, however, no studies have examined whether menthol in cigarettes has central pharmacological effects. OBJECTIVE:We investigated psychophysiological and subjective effects of smoking menthol versus non-menthol cigarettes in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050947
更新日期:1999-04-01 00:00:00
abstract:RATIONALE:A sensitized dopamine system may be linked to the genesis of psychotic symptoms in schizophrenia. Following withdrawal from amphetamine exposures, psychotic-like traits have been robustly demonstrated, but the presence of cognitive/mnemonic deficits remains uncertain. METHODS:Adult male Lewis and Fischer rat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1514-7
更新日期:2009-11-01 00:00:00
abstract:RATIONALE:Working memory performance may be improved or decreased by amphetamine, depending on baseline working memory capacity and amphetamine dosage. This variable effect suggests an optimal range of monaminergic activity for working memory, either below or above which it is compromised. We directly tested this possi...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0025-4
更新日期:2005-08-01 00:00:00