Abstract:
RATIONALE:Traditional remedies prepared from Ptychopetalum olacoides (PO) are used throughout the Amazon to alleviate age-related conditions. These formulas are mainly used by elders, and alleged effects may be related to the anticholinesterase properties identified in a standardized ethanol extract of this species [P. olacoides standardized ethanol extract (POEE)]. OBJECTIVES:To further characterize the potential of this extract for developing drugs useful to treat cognitive deficits, the effects of POEE on scopolamine (scop)- and MK801-induced amnesias (acquisition, consolidation, and retrieval) in mice were investigated. RESULTS:Scop (3.0 mg/kg, ip) significantly impaired memory (all three phases) in the step-down inhibitory avoidance protocol. As expected, MK801 (0.1 mg/kg, ip) was amnesic regarding acquisition and consolidation, but not retrieval. POEE (100 mg/kg, ip) reversed the scop-induced impairment in all three phases of long-term and short memories, whereas only the memory consolidation deficit was reversed with MK801-induced amnesia. CONCLUSIONS:This study complements previously reported promnesic properties of this plant extract and suggests that POEE may be further developed for treating conditions associated with cognitive deficits, especially those linked with cholinergic malfunction.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
da Silva AL,Silva Martins Bd,Linck Vde M,Herrmann AP,Mai N,Nunes DS,Elisabetsky Edoi
10.1007/s00213-008-1272-ysubject
Has Abstractpub_date
2009-01-01 00:00:00pages
165-72issue
1-3eissn
0033-3158issn
1432-2072journal_volume
202pub_type
杂志文章abstract::Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1991-01-01 00:00:00
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doi:10.1007/s002130051063
更新日期:1999-08-01 00:00:00
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doi:10.1007/s00213-002-1059-5
更新日期:2002-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1981-01-01 00:00:00
abstract::Serotonin (5-HT) afferents may modulate the dopamine mesoaccumbens circuit, which has been shown to be critically involved in the locomotor stimulatory, discriminative stimulus, and rewarding properties of cocaine. In the present study, we investigated the role of 5-HT1A receptors in the ventral tegmental area (VTA) i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050586
更新日期:1998-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05225-z
更新日期:2019-07-01 00:00:00
abstract:RATIONALE:Acute nicotine abstinence is associated with disruption of executive function and reward processes; however, the neurobiological basis of these effects has not been fully elucidated. METHODS:The effects of nicotine abstinence on brain function during reward-based probabilistic decision making were preliminar...
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pub_type: 杂志文章
doi:10.1007/s00213-011-2404-3
更新日期:2012-01-01 00:00:00