The discriminative stimulus properties of cocaine: effects of microinfusion of cocaine, a 5-HT1A agonist or antagonist, into the ventral tegmental area.


:Serotonin (5-HT) afferents may modulate the dopamine mesoaccumbens circuit, which has been shown to be critically involved in the locomotor stimulatory, discriminative stimulus, and rewarding properties of cocaine. In the present study, we investigated the role of 5-HT1A receptors in the ventral tegmental area (VTA) in mediating the discriminative stimulus effects of cocaine. Male Sprague-Dawley rats were trained to discriminate cocaine (10 mg/kg) from saline in a two-lever, water-reinforced FR 20 task. After acquiring the cocaine-saline discrimination, rats were stereotaxically implanted with bilateral guide cannulae into the VTA or adjacent substantia nigra reticulata (SNR). Intraperitoneal administration of cocaine (0.625-10 mg/kg) produced a dose-related increase in drug-lever responding. Both intra-VTA and intra-SNR infusion of cocaine (12.5-50 microg/0.5 microl/side) engendered primarily saline-like responding. Microinjection of the 5-HT1A agonist 8-hydroxy-2-(di-N-propylamino) tetralin (DPAT; 0.1-10 microg/0.5 microl/side) or the 5-HT1A antagonist WAY 100635 (0.01-1.0 microg/0.5 microl/side) into the VTA or SNR did not substitute for the systemic cocaine cue. Further, intra-VTA or intra-SNR DPAT or WAY 100635 in combination with systemic doses of cocaine did not alter (i.e., attenuate or potentiate) the systemic cocaine cue. Overall, these data indicate that 5-HT1A receptors in the VTA do not mediate or modulate the discriminative stimulus effects of cocaine in the rat.




De La Garza R 2nd,Callahan PM,Cunningham KA




Has Abstract


1998-05-01 00:00:00












  • Glucocorticoid mechanisms may contribute to ECT-induced retrograde amnesia.

    abstract:RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...


    pub_type: 杂志文章


    authors: Nagaraja N,Andrade C,Sudha S,Madan Singh N,Chandra JS,Venkataraman BV

    更新日期:2007-01-01 00:00:00

  • Amphetamine-induced appetitive 50-kHz calls in rats: a marker of affect in mania?

    abstract:RATIONALE:Animal models aimed to mimic mania have in common the lack of genuine affective parameters. Although rodent amphetamine-induced hyperlocomotion is a frequently used behavioral model of mania, locomotor activity is a rather unspecific target for developing new pharmacological therapies, and does not necessaril...


    pub_type: 杂志文章


    authors: Pereira M,Andreatini R,Schwarting RK,Brenes JC

    更新日期:2014-07-01 00:00:00

  • Flurazepam effects on methylphenidate-induced stereotyped behavior.

    abstract::The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and nighttime experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of met...


    pub_type: 杂志文章


    authors: Risch C,Kripke D,Janowsky D

    更新日期:1980-01-01 00:00:00

  • Maintenance therapy with zuclopenthixol decanoate: associations between plasma concentrations, neurological side effects and CYP2D6 genotype.

    abstract:RATIONALE:Several antipsychotic drugs are metabolised by the polymorphic cytochrome P(450) CYP2D6. The impact of the polymorphism on the plasma levels and the occurrence of side effects have not been clearly established. OBJECTIVE:To investigate the impact of the CYP2D6 polymorphism on the steady-state plasma concentr...


    pub_type: 杂志文章


    authors: Jaanson P,Marandi T,Kiivet RA,Vasar V,Vään S,Svensson JO,Dahl ML

    更新日期:2002-06-01 00:00:00

  • The relationship between stereotypy and memory improvement produced by amphetamine.

    abstract::This study examined the possibility that amphetamine-induced stereotypy and facilitation of memory consolidation are both mediated by amphetamine's stimulation of dopaminergic activity in the caudate nucleus. In the first experiment, rats were given pairings of a tone and a shock followed by SC amphetamine (2 mg/kg). ...


    pub_type: 杂志文章


    authors: Carr GD,White NM

    更新日期:1984-01-01 00:00:00

  • Serotonergic function during lithium augmentation of refractory depression.

    abstract::Serotonergic mechanisms have been implicated in the pathophysiology of depression and in the neuropharmacology of antidepressant treatment. One measure of central serotonergic function is the prolactin (PRL) response to IV L-tryptophan (L-TRP). We used the L-TRP test to assess the role of serotonin in the mechanism of...


    pub_type: 杂志文章


    authors: McCance-Katz E,Price LH,Charney DS,Heninger GR

    更新日期:1992-01-01 00:00:00

  • Separate and combined effects of marijuana and alcohol on mood, equilibrium and simulated driving.

    abstract:RATIONALE:Marijuana and alcohol, when used separately and in combination, contribute to automobile accidents and failed sobriety tests of standing balance. However, the extent to which the drugs have additive effects on both of these measures is unknown. OBJECTIVES:This study was designed to compare directly the separ...


    pub_type: 临床试验,杂志文章


    authors: Liguori A,Gatto CP,Jarrett DB

    更新日期:2002-10-01 00:00:00

  • A randomized controlled trial of ganaxolone in posttraumatic stress disorder.

    abstract::Preclinical and clinical research supports a role for neuroactive steroids in the pathophysiology of posttraumatic stress disorder (PTSD). We investigated ganaxolone (a synthetic 3β-methylated derivative of allopregnanolone, a GABAergic neuroactive steroid) for treatment of PTSD in a proof-of-concept, multisite, doubl...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rasmusson AM,Marx CE,Jain S,Farfel GM,Tsai J,Sun X,Geracioti TD,Hamner MB,Lohr J,Rosse R,Summerall L,Naylor JC,Cusin C,Lang AJ,Raman R,Stein MB

    更新日期:2017-08-01 00:00:00

  • Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia.

    abstract:OBJECTIVE:Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this assoc...


    pub_type: 杂志文章


    authors: Zhang XY,Liang J,Chen DC,Xiu MH,Yang FD,Kosten TA,Kosten TR

    更新日期:2012-07-01 00:00:00

  • Effects of pentobarbital and progesterone on random ratio responding in male and female rats.

    abstract::Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...


    pub_type: 杂志文章


    authors: Heinsbroek RP,van Haaren F,Zantvoord F,van de Poll NE

    更新日期:1987-01-01 00:00:00

  • Cigarette smoking in rhesus monkeys.

    abstract::In the present pilot study, an attempt was made to shape and maintain cigarette smoking behavior in rhesus monkeys both with and without the simultaneous use of other reinforcers. Initially, 14 monkeys were trained to suck air and puff on cigarettes using sweetened liquid reinforcer. After smoking had been established...


    pub_type: 杂志文章


    authors: Ando K,Yanagita T

    更新日期:1981-01-01 00:00:00

  • Increased aggression after ethanol self-administration in male resident rats.

    abstract::In order to study experimental alcohol intake that leads to heightened aggression, we established ethanol self-administration in aggressive rats. The focus was on low doses of self-administered ethanol and to assess their effects on aggressive behavior in resident rats, using a limited access paradigm followed by a 5-...


    pub_type: 杂志文章


    authors: van Erp AM,Miczek KA

    更新日期:1997-06-01 00:00:00

  • Effect of clozapine upon schedule-induced polydipsia (SIP) resembles neither the actions of dopamine D1 nor D2 blockade.

    abstract::The effects of clozapine (CLOZ) upon acquired schedule-induced polydipsia in rats were compared to the effects of the dopamine (DA) D1 antagonist SCH 23390 (SCH) and the DA D2 antagonist raclopride (RAC). All three compounds suppressed water consumption, but only SCH and RAC decreased drinking efficiency. SCH was the ...


    pub_type: 杂志文章


    authors: Didriksen M,Olsen GM,Christensen AV

    更新日期:1993-01-01 00:00:00

  • The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats.

    abstract:RATIONALE:The metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs of abuse. OBJECTIVES:The purpose of the present study was to explore whether MPEP-induced decreases in nicotine and cocaine self-administration reflect attenuation of the reinforcing and inc...


    pub_type: 杂志文章


    authors: Paterson NE,Markou A

    更新日期:2005-04-01 00:00:00

  • Differential effects of dopaminergic agonists on food-reinforced operant behavior in the long-tailed macaque (Macaca fascicularis).

    abstract::Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...


    pub_type: 杂志文章


    authors: Dooley DJ,Bowden DM

    更新日期:1983-01-01 00:00:00

  • Differentiating the sedative, psychomotor and amnesic effects of benzodiazepines: a study with midazolam and the benzodiazepine antagonist, flumazenil.

    abstract::Sixteen healthy volunteers were administered midazolam followed by placebo or the benzodiazepine antagonist, flumazenil, in a double-blind, cross-over study. Flumazenil reversed midazolam-induced sedation on the subjective, psychophysiological and motor indices used. In contrast, there was little evidence of any rever...


    pub_type: 临床试验,杂志文章


    authors: Curran HV,Birch B

    更新日期:1991-01-01 00:00:00

  • Behavioural and electoencephalographic interactions between haloperidol and PCP/sigma ligands in the rat.

    abstract::Phencyclidine (PCP) and sigma ligands produce a typical excitatory behaviour in rats, characterized by circling and head- and body-weaving. Excitatory amino acid antagonists such as 2-amino 5-phosphonovaleric acid (AP5) or 3-(+/-)-2-carboxypiperazin-4-yl)propyl-l-phosphonic acid (CPP) also produce a PCP-like excitator...


    pub_type: 杂志文章


    authors: Sagratella S,Scotti de Carolis A,Pèzzola A,Popoli P

    更新日期:1991-01-01 00:00:00

  • Naltrexone moderates the relationship between cue-induced craving and subjective response to methamphetamine in individuals with methamphetamine use disorder.

    abstract:RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...


    pub_type: 杂志文章


    authors: Roche DJO,Worley MJ,Courtney KE,Bujarski S,London ED,Shoptaw S,Ray LA

    更新日期:2017-07-01 00:00:00

  • Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs.

    abstract::Prepulse inhibition (PPI) of an acoustic startle response is impaired in schizophrenics. PPI can also be studied in the rat, and is impaired by dopamine (DA) D2/3 receptor agonists such as apomorphine. This disruption is reversed by DA antagonists, leading to proposals that this approach may be a useful means to ident...


    pub_type: 杂志文章


    authors: Varty GB,Higgins GA

    更新日期:1995-11-01 00:00:00

  • The effect of peripheral noradrenaline depletion on responding on a schedule of differential reinforcement of low rates of response (DRL).

    abstract::First, it was confirmed that systemic injection of the neurotoxin 6-hydroxydopamine HBr (30 mg/kg IP) depleted noradrenaline levels in rat heart, but not centrally. Losses averaged 90% of control 1 day after injection, and 50% at 42 days. The same drug and dose was then administered to 50% of a group of rats which had...


    pub_type: 杂志文章


    authors: Salmon P,Stanford C,Gray JA

    更新日期:1985-01-01 00:00:00

  • Animal models of Parkinson's disease and L-dopa induced dyskinesia: how close are we to the clinic?

    abstract:BACKGROUND:Several different animal models are currently used to research the neurodegenerative movement disorder Parkinson's disease (PD). RESULTS:Models based on the genetic deficits associated with a small percentage of sufferers demonstrate the pathological accumulation of alpha-synuclein characteristic of the dis...


    pub_type: 杂志文章,评审


    authors: Lane E,Dunnett S

    更新日期:2008-08-01 00:00:00

  • Inhibition of conditional avoidance response by neuroleptics upon repeated administration.

    abstract::Development of tolerance to neuroleptic compounds tested in the conditional avoidance model was investigated. Since tolerance may manifest itself by a diminished potency and/or a shortened duration of effect, the complete time course of effect was registered in these experiments. Rats were pretreated approximately 2 w...


    pub_type: 杂志文章


    authors: Danneskiold-Samsøoe P,Pedersen V

    更新日期:1976-12-21 00:00:00

  • Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat.

    abstract::There is a latency period of several weeks before the onset of clinical effect of antidepressant drugs. The detailed mechanisms underlying drug-induced adaptive neuronal changes are not known. To elucidate the involvement of changes in gene expression of candidate transcription factors, we treated rats for 21 days wit...


    pub_type: 杂志文章


    authors: Bjartmar L,Johansson IM,Marcusson J,Ross SB,Seckl JR,Olsson T

    更新日期:2000-07-01 00:00:00

  • REM sleep suppression induced by selective monoamine oxidase inhibitors.

    abstract::The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cohen RM,Pickar D,Garnett D,Lipper S,Gillin JC,Murphy DL

    更新日期:1982-01-01 00:00:00

  • Translating the smoking cessation properties of the antidepressant nortriptyline using reinforcing, discriminative and aversive stimulus effects of nicotine in rats.

    abstract:RATIONALE:The antidepressant nortriptyline is a second-line pharmacotherapy for smoking cessation. Given that there is limited preclinical data available on the effects of nortriptyline on responses to nicotine, the present study sought to evaluate its effects on the reinforcing, discriminative stimulus (DS) and aversi...


    pub_type: 杂志文章


    authors: Wing VC,Shoaib M

    更新日期:2012-02-01 00:00:00

  • 5-Methoxy-N,N-dimethyltryptamine: spinal cord and brainstem mediation of excitatory effects on acoustic startle.

    abstract::The effects of different doses (0.03, 0.06, 0.12, 0.25, 1.0, 2.0, 4.0, and 8.0 mg/kg body weight) of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) were tested on the acoustic startle reflex in rats. Beginning at 0.12 mg/kg, 5-MeODMT increased startle monotonically up to the highest dose used. 5-MeODMT still increased st...


    pub_type: 杂志文章


    authors: Davis M,Astrachan DI,Gendelman PM,Gendelman DS

    更新日期:1980-01-01 00:00:00

  • Previous experience of ethanol withdrawal increases withdrawal-induced c-fos expression in limbic areas, but not withdrawal-induced anxiety and prevents withdrawal-induced elevations in plasma corticosterone.

    abstract:RATIONALE:Increased anxiety is a characteristic of the acute ethanol withdrawal syndrome. Repeated exposure of rats to withdrawal from chronic ethanol increases sensitivity to seizures. OBJECTIVES:We investigated whether repeated withdrawal experience increases withdrawal-induced anxiety and stress, and if it changes ...


    pub_type: 杂志文章


    authors: Borlikova GG,Le Merrer J,Stephens DN

    更新日期:2006-04-01 00:00:00

  • Blockade of the discriminative effects of morphine in the rat by naltrexone and naloxone.

    abstract::The capacity of the specific narcotic antagonists naltrexone and naloxone to block the discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete-trial avoidance task. The antagonists produced a dose-dependent and time-dependent blockade of morphine's effects as measured by resp...


    pub_type: 杂志文章


    authors: Shannon HE,Holtzman SG

    更新日期:1976-11-10 00:00:00

  • Differential vulnerability to relapse into heroin versus cocaine-seeking as a function of setting.

    abstract:RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...


    pub_type: 杂志文章


    authors: Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

    更新日期:2015-07-01 00:00:00

  • Thermal sensitivity across ages and during chronic fentanyl administration in rats.

    abstract:RATIONALE:Chronic pain is becoming a more common medical diagnosis and is especially prevalent in older individuals. As such, prescribed use of opioids is on the rise, even though the efficacy for pain management in older individuals is unclear. OBJECTIVES:Thus, the present preclinical study assessed the effectiveness...


    pub_type: 杂志文章


    authors: Mitzelfelt JD,Carter CS,Morgan D

    更新日期:2014-01-01 00:00:00