Aberrant glutamate signaling in the prefrontal cortex and striatum of the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder.

abstract：OBJECTIVES:The present study investigates the effects of injections of a specific N-methyl-D-aspartic acid (NMDA) antagonist 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phophonic acid (CPP) into the prefrontal cortex (PFC) on the extracellular concentrations of dopamine and acetylcholine in the nucleus accumbens (NAc) and...

journal_title：Psychopharmacology

authors： Del Arco A,Segovia G,Mora F

更新日期：2008-12-01 00:00:00

abstract：:Preclinical studies suggest that acoustic startle amplitude is increased during ethanol withdrawal. The current study evaluated the effects of intravenous infusion of the alpha 2-adrenergic antagonist, yohimbine (0.4 mg/kg), the serotonin partial agonist m-chlorophenylpiperazine (mCPP, 0.1 mg/kg), and placebo administ...

journal_title：Psychopharmacology

authors： Krystal JH,Webb E,Grillon C,Cooney N,Casal L,Morgan CA 3rd,Southwick SM,Davis M,Charney DS

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Serotonergic mechanisms are thought to play an important role in the regulation of mood, motor activity and sleep patterns. Serotonin reuptake is controlled by the serotonin transporter (5-HTT) and by a common functional insertion/deletion polymorphism in the corresponding gene's promoter region (5-HTTLPR). H...

journal_title：Psychopharmacology

authors： Putzhammer A,Schoeler A,Rohrmeier T,Sand P,Hajak G,Eichhammer P

更新日期：2005-03-01 00:00:00

abstract：RATIONALE:Investigations of the neural consequences of the effects of cocaine on cognition have centered on specific brain circuits including prefrontal cortex, medial temporal lobe and striatum and their roles in controlling drug dependent behavior and addiction. These regions are critical to many aspects of drug abus...

journal_title：Psychopharmacology

authors： Hampson RE,Porrino LJ,Opris I,Stanford T,Deadwyler SA

更新日期：2011-01-01 00:00:00

abstract：:The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the mu-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the kap...

journal_title：Psychopharmacology

authors： Shippenberg TS,Emmett-Oglesby MW,Ayesta FJ,Herz A

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...

journal_title：Psychopharmacology

authors： Concas A,Sogliano C,Porcu P,Marra C,Brundu A,Biggio G

更新日期：2006-06-01 00:00:00

abstract：:Rats were trained to self-stimulate by interrupting a photobeam and brain stimulation was maintained for as long as the beam of light was broken. d-Amphetamine sulphate was then administered and response rate and total duration of stimulation were recorded. Both response rate and total duration were elevated by 1.0, 2...

journal_title：Psychopharmacology

authors： Zacharko RM,Wishart TB

更新日期：1979-08-08 00:00:00

abstract：:The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.1 mg/kg IV), or placebo prior to 0.3 mg/kg IV amphetamine. Healthy volunteers (N = 12) partici...

journal_title：Psychopharmacology

authors： Nurnberger JI Jr,Simmons-Alling S,Kessler L,Jimerson S,Schreiber J,Hollander E,Tamminga CA,Nadi NS,Goldstein DS,Gershon ES

更新日期：1984-01-01 00:00:00

abstract：:Single-dose pharmacokinetics of alprazolam was studied in 42 normal male volunteers (14 Caucasians, 14 American-born Asians, and 14 foreign-born Asians), after both oral and parenteral (IV) administration of a small dose (0.5 mg) of the test drug. Asians manifested significantly higher Cmax, larger AUC, slower CL and ...

journal_title：Psychopharmacology

authors： Lin KM,Lau JK,Smith R,Phillips P,Antal E,Poland RE

更新日期：1988-01-01 00:00:00

abstract：:The effects of monoamine oxidase inhibitors (MAOIs) that selectively inhibit the MAO-A or MAO-B forms of MAO were studied in rats performing under a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule of reinforcement. Clorgyline and CGP11'305A, irreversible and reversible MAO-A inhibitors, respectively, i...

journal_title：Psychopharmacology

authors： Marek GJ,Seiden LS

更新日期：1988-01-01 00:00:00

abstract：:This study demonstrates that pre-exposure to stress influences subsequent effects of stress on pain sensitivity (stress-induced analgesia) and on plasma corticosterone and brain catecholamine activity. Animals exposed to a 30 min shock session (S1 = 8, 5.0 s shocks) 10 days earlier showed a significant attenuation of ...

journal_title：Psychopharmacology

authors： Caggiula AR,Antelman SM,Aul E,Knopf S,Edwards DJ

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Pavlovian conditioning with a discrete reward-predictive visual cue can elicit two classes of behaviors: "sign-tracking" (approach toward and contact with the cue) and "goal-tracking" (approach toward the site of reward delivery). Sign-tracking has been proposed to be linked to behavioral disorders involving ...

journal_title：Psychopharmacology

authors： Simon NW,Mendez IA,Setlow B

更新日期：2009-03-01 00:00:00

abstract：RATIONALE:Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction. OBJ...

journal_title：Psychopharmacology

authors： Panlilio LV,Thorndike EB,Schindler CW

更新日期：2003-07-01 00:00:00

abstract：:The effect of the selective noradrenaline neurotoxin DSP4 on steady-state operant behaviour was examined using a quantitative behavioural paradigm based on Herrnstein's (1970) equation, which defines a hyperbolic relationship between steady-state response rate and reinforcement frequency in variable-interval schedules...

journal_title：Psychopharmacology

authors： Morley MJ,Shah K,Bradshaw CM,Szabadi E

更新日期：1988-01-01 00:00:00

abstract：:The relationship between norepinephrine (NE) content in cortex and spinal cord and acoustic startle amplitude was investigated in two experiments. Administration of diethyldithiocarbamate (DDC) depressed startle amplitude at the same time and dose that it most severely depleted NE content. These results support the co...

journal_title：Psychopharmacology

authors： Storm JE,Millington WR,Fechter LD

更新日期：1984-01-01 00:00:00

abstract：:In a placebo-controlled study, we investigated the influence of nicotine on late-day aviation performance in 15 non-smoking subjects. In a within-subjects design, subjects were tested on 2 days, each lasting 8 h and consisting of three 75-min simulator flights (late-afternoon practice, evening test, night test). Prior...

journal_title：Psychopharmacology

authors： Mumenthaler MS,Taylor JL,O'Hara R,Yesavage JA

更新日期：1998-11-01 00:00:00

abstract：:Serotonergic mechanisms mediate the expression of personality traits (such as impulsivity, aggression and anxiety) that are linked to vulnerability to psychological illnesses, and modulate the identification of emotional expressions in the face as well as learning about broader classes of appetitive and aversive signa...

journal_title：Psychopharmacology

authors： Ward R,Sreenivas S,Read J,Saunders KEA,Rogers RD

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of cholinergic receptor blockade in the rat prefrontal cortex on cognitive processes. The nicotinic antagonists neuronal bungarotoxin and dihydro-beta-erythroidine and the muscarinic antagonist scopolamine were injected into the prelimbic area of the prefrontal ...

journal_title：Psychopharmacology

authors： Granon S,Poucet B,Thinus-Blanc C,Changeux JP,Vidal C

更新日期：1995-05-01 00:00:00

abstract：:Exposure to 10 min of footshock stress (1 mA; 0.5 s on, with a mean off period of 40 s) reinstated heroin-seeking behavior in heroin-experienced, drug-free rats after many sessions of extinction and up to 6 weeks after last exposure to heroin. In reinstating the behavior, the footshock mimicked the effect of a non-con...

journal_title：Psychopharmacology

authors： Shaham Y,Stewart J

更新日期：1995-06-01 00:00:00

abstract：RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as thes...

journal_title：Psychopharmacology

authors： Bowen DM,Procter AW,Mann DM,Snowden JS,Esiri MM,Neary D,Francis PT

更新日期：2008-03-01 00:00:00

abstract：:Two experiments were conducted to test the hypothesis that tolerance to the hypothermic effect of ethanol fails to develop if rats are denied the unconditional stimulus represented by hypothermia. In both experiments, rats were injected with either ethanol (1.9 or 2.5 g/kg) or saline and given microwave hyperthermia (...

journal_title：Psychopharmacology

authors： Hjeresen DL,Reed DR,Woods SC

更新日期：1986-01-01 00:00:00

abstract：:The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...

journal_title：Psychopharmacology

authors： Havemann U,Magnus B,Möller HG,Kuschinsky K

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Serotonin and especially serotonin 2A (5-HT(2A)) receptor signaling are important in the etiology and treatment of schizophrenia and affective disorders. We previously reported a novel 5-HT(2A) receptor effector, increased transglutaminase (TGase)-catalyzed transamidation, and activation of the small G protei...

journal_title：Psychopharmacology

authors： Dai Y,Dudek NL,Li Q,Muma NA

更新日期：2011-02-01 00:00:00

abstract：:The effects of olanzapine [LY 170053; 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2, 3b] [1,5]benzodiazepine), a potential atypical antipsychotic, were determined in pigeons whose keypeck responding was punished. These effects were compared to the anxiolytic agents chlordiazepoxide and pentobarbital, and to other a...

journal_title：Psychopharmacology

authors： Benvenga MJ,Leander JD

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic-pituitary-adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, compounds that block the effects of stress hormones were investigated as potential therapeu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Wood SK,Houshyar H,Hsin LW,Rice KC,Woods JH

更新日期：2005-07-01 00:00:00

abstract：:Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...

journal_title：Psychopharmacology

authors： Biegon A,Greuner N

更新日期：1992-01-01 00:00:00

abstract：:Cortical and hippocampal EEGs in animal models of schizophrenia were compared to those obtained with psychotomimetics or antipsychotic agents by utilizing power spectral analysis. Models of positive schizophrenic symptoms were created with methamphetamine (MAP) and cocaine, and a model of both negative and positive sy...

journal_title：Psychopharmacology

authors： Yamamoto J

更新日期：1997-06-01 00:00:00

abstract：:Quetiapine (Seroquel, ICI 204,636) is an atypical antipsychotic that is effective in the treatment of both positive and negative symptoms of schizophrenia, and has a low propensity to cause extrapyramidal symptoms. The compound has a relatively short plasma elimination half-life (approximately 7 h). However, since dop...

journal_title：Psychopharmacology

authors： King DJ,Link CG,Kowalcyk B

更新日期：1998-05-01 00:00:00

abstract：RATIONALE:Dopaminergic therapy improves some cognitive functions and worsens others in patients with Parkinson's disease (PD). These paradoxical effects are explained by the dopamine overdose hypothesis, which proposes that effects of dopaminergic therapy on a cognitive function is determined by the baseline dopamine l...

journal_title：Psychopharmacology

authors： Vo A,Seergobin KN,Morrow SA,MacDonald PA

更新日期：2016-07-01 00:00:00

abstract：:Monoamine oxidases A and B (MAO-A and B) catalyze the oxidative catabolism of biogenic amines and xenobiotics. Investigation of these mitochondrial membrane proteins shows that they differ in substrate preference, inhibitor specificity, tissue and neuronal cell distribution, immunological properties, and nucleotide an...

journal_title：Psychopharmacology

authors： Kwan SW,Bergeron JM,Abell CW

更新日期：1992-01-01 00:00:00