A comparison of bd and tid dose regimens of quetiapine (Seroquel) in the treatment of schizophrenia.


:Quetiapine (Seroquel, ICI 204,636) is an atypical antipsychotic that is effective in the treatment of both positive and negative symptoms of schizophrenia, and has a low propensity to cause extrapyramidal symptoms. The compound has a relatively short plasma elimination half-life (approximately 7 h). However, since dopamine D2 receptor occupancies correlate poorly with plasma concentrations of antipsychotics, plasma elimination half-life may not predict either duration of clinical effect or dosing frequency. Accordingly, the efficacy and tolerability of three dosing regimens (450 mg/day given in two or three divided doses daily, and 50 mg/day given twice daily) were compared in a 6-week, double-blind, randomized, multicentre, parallel-group study. The study recruited hospitalized men and women aged 18-65 years meeting DSM-IIIR criteria for acute exacerbation of chronic or subchronic schizophrenia. Six hundred and eighteen patients were randomly assigned to treatment with quetiapine 150 mg tid (n = 209), 225 mg bd (n = 200), or a comparator dose of 25 mg bd (n = 209). At day 42, the last day of randomized treatment and the primary timepoint for efficacy, quetiapine 450 mg/day was more effective than 50 mg/day: 225 mg bd was consistently superior to 25 mg bd in all measures of efficacy (total BPRS, P = 0.006; CGI severity, CGI improvement and SANS, P < 0.03), and 150 mg tid was statistically significantly superior to 25 mg bd with respect to BPRS total score (P = 0.05). The 225 mg bd and 150 mg tid groups were not significantly different from each other with respect to any efficacy measure. Quetiapine was generally well tolerated. Extrapyramidal symptom (EPS) adverse events were generally rare, and occurred with similar frequencies in the two 450 mg/day groups. Quetiapine was not associated with sustained increases in plasma prolactin at any dose. These data support the atypical profile developed from preclinical studies and show that quetiapine is an effective, well tolerated antipsychotic that can be given twice daily.




King DJ,Link CG,Kowalcyk B




Has Abstract


1998-05-01 00:00:00












  • Pindolol binding to 5-HT1A receptors in the human brain confirmed with positron emission tomography.

    abstract::The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...


    pub_type: 杂志文章


    authors: Andrée B,Thorberg SO,Halldin C,Farde L

    更新日期:1999-06-01 00:00:00

  • Modification of the behavioral effects of morphine in rats by serotonin 5-HT₁A and 5-HT₂A receptor agonists: antinociception, drug discrimination, and locomotor activity.

    abstract:RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the specific 5-HT receptor subtype(s) mediating this enhancement is not established. OBJECTIVE:This study examined interactions between morphine and both 5-HT(1A) and 5-HT(2A) receptor agonists in...


    pub_type: 杂志文章


    authors: Li JX,Shah AP,Patel SK,Rice KC,France CP

    更新日期:2013-02-01 00:00:00

  • Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats.

    abstract:RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...


    pub_type: 杂志文章


    authors: Harun N,Johari IS,Mansor SM,Shoaib M

    更新日期:2020-03-01 00:00:00

  • Effect of 5,7-dihydroxytryptamine on the development of tolerance to ethanol.

    abstract::5,7-Dihydroxytryptamine (5,7-DHT) or the vehicle was administered once into both lateral ventricles of the rat. Desmethylimipramine (DMI) was administered IP prior to the intraventricular injection of 5,7-DHT to prevent the destruction of norepinephrine (NE) terminals. Following recovery from surgery, ethanol (5 g/kg,...


    pub_type: 杂志文章


    authors: Lê AD,Khanna JM,Kalant H,LeBlanc AE

    更新日期:1980-02-01 00:00:00

  • The scopolamine model as a pharmacodynamic marker in early drug development.

    abstract:RATIONALE:Drug development is a high-risk and high failure enterprise, and studies that provide an early read on the pharmacodynamic activity of novel compounds could save time and money, increasing the efficiency of the drug development process. OBJECTIVE:Preclinical and clinical experiments were designed to examine ...


    pub_type: 杂志文章,随机对照试验


    authors: Lenz RA,Baker JD,Locke C,Rueter LE,Mohler EG,Wesnes K,Abi-Saab W,Saltarelli MD

    更新日期:2012-03-01 00:00:00

  • The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats.

    abstract:RATIONALE:Coping styles are fundamental characteristics of behavior that affect susceptibility to, and resilience during, mental and physical illness. Shifts from passive to active coping are considered therapeutic goals in many stress-related disorders, but the neural control of coping is poorly understood. Based on e...


    pub_type: 杂志文章


    authors: Haller J,Goldberg SR,Pelczer KG,Aliczki M,Panlilio LV

    更新日期:2013-12-01 00:00:00

  • Oral behaviour induced by intranigral muscimol is unaffected by haloperidol but abolished by large lesions of superior colliculus.

    abstract::It has been suggested that the GAbAergic striatonigral projection may form part of the efferent pathway responsible for the expression of dopamine-related oral behaviour. Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting. We rep...


    pub_type: 杂志文章


    authors: Taha EB,Dean P,Redgrave P

    更新日期:1982-01-01 00:00:00

  • Interactions among the cannabinoids in the antagonism of the abdominal constriction response in the mouse.

    abstract::The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective a...


    pub_type: 杂志文章


    authors: Sanders J,Jackson DM,Starmer GA

    更新日期:1979-03-28 00:00:00

  • A comparison of the effects of d- and l-fenfluramine and d-amphetamine on energy and macronutrient intake in human subjects.

    abstract::The anorectic activity of the d and l isomers of d-fenfluramine (d-FF) (l-FF) were compared with d-amphetamine (d-amp) when given separately and together in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser. Anorectic activity was ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Goodall E,Feeney S,McGuirk J,Silverstone T

    更新日期:1992-01-01 00:00:00

  • Dopamine receptor alteration in schizophrenia: neuroendocrine evidence.

    abstract::Growth hormone (hGH) responses to centrally acting dopamine agonists were used as indices of CNS dopaminergic function in order to test hypotheses implicating dopaminergic alteration in the etiopathology of schizophrenia. Apomorphine, a direct acting dopamine receptor agonist, and L-Dopa, an indirect agonist dependent...


    pub_type: 杂志文章


    authors: Rotrosen J,Angrist BM,Gershon S,Sachar EJ,Halpern FS

    更新日期:1976-12-21 00:00:00

  • The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients.

    abstract::7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly ...


    pub_type: 杂志文章


    authors: Alfredsson G,Lindberg M,Sedvall G

    更新日期:1982-01-01 00:00:00

  • Effect of delta 9-tetrahydrocannabinol on the morphine-induced hyperactivity of mice.

    abstract::The effect of delta 9-tetrahydrocannabinol (THC) on the locomotor activity-stimulating action of morphine has been investigated in mice. THC (10 mg/kg) has been found to potentiate morphine-induced hyperactivity. On the other hand, the stimulating action of morphine on motor activity strongly diminished in mice render...


    pub_type: 杂志文章


    authors: Ulkü E,Ayhan IH,Tulunay FC,Uran B,Kaymakçalan S

    更新日期:1980-01-01 00:00:00

  • The demethylation of amitriptyline: a cross-over study of steady-state plasma levels of amitriptyline and nortriptyline in depressed patients.

    abstract::Five elderly depressed patients were treated with amitriptyline (AT) and nortriptyline (NT) in turn, in a cross-over design. Steady-state plasma drug levels were compared with those calculated for eight healthy subjects of previous single-dose studies. Plasma clearances were on average about 2.5 times lower in the pat...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Burch JE

    更新日期:1983-01-01 00:00:00

  • Evidence for monoaminergic involvement in triadimefon-induced hyperactivity.

    abstract::Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...


    pub_type: 杂志文章


    authors: Crofton KM,Boncek VM,MacPhail RC

    更新日期:1989-01-01 00:00:00

  • Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects.

    abstract:RATIONALE:Pharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) pro...


    pub_type: 杂志文章


    authors: Madsen K,Erritzoe D,Mortensen EL,Gade A,Madsen J,Baaré W,Knudsen GM,Hasselbalch SG

    更新日期:2011-02-01 00:00:00

  • The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboons.

    abstract:RATIONALE:Caffeine and the adenosine A(1) and A(2A) receptor antagonist CGS15943 produce many behavioral effects that are similar to those produced by classic stimulant drugs (e.g. cocaine and amphetamines). OBJECTIVES:The current study evaluated whether CGS15943 would maintain self-administration and reinstate exting...


    pub_type: 杂志文章


    authors: Weerts EM,Griffiths RR

    更新日期:2003-07-01 00:00:00

  • Effects of single and long-term haloperidol administration on open field behavior of rats.

    abstract::The effects of single and long-term haloperidol administration on rat open field behavior was studied. Withdrawal from long-term haloperidol treatment induced a significant increase in all parameters of activity recorded, except rearing. There was a direct relationship between the impairment of motor function induced ...


    pub_type: 杂志文章


    authors: Bernardi MM,De Souza H,Palermo Neto J

    更新日期:1981-01-01 00:00:00

  • Efficacy of olanzapine monotherapy for treatment of bipolar I depression: a randomized, double-blind, placebo controlled study.

    abstract:RATIONALE AND OBJECTIVE:Depression symptoms are now recognized to be the predominant cause of disability for bipolar disorder (BD) patients. The treatment strategies for the depressed phase of BD remain more anecdotal than data-based. Olanzapine has been investigated as an alternative to antidepressants and a mood stab...


    pub_type: 杂志文章,随机对照试验


    authors: Wang M,Tong JH,Huang DS,Zhu G,Liang GM,Du H

    更新日期:2014-07-01 00:00:00

  • Atypical antipsychotics: are some more atypical than others?

    abstract::On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...


    pub_type: 杂志文章,评审


    authors: Remington G,Kapur S

    更新日期:2000-01-01 00:00:00

  • fMRI predictors of treatment outcome in pediatric anxiety disorders.

    abstract:INTRODUCTION:A growing number of studies have found evidence that anxiety and depressive disorders are associated with atypical amygdala hyperactivation, which decreases with effective treatment. Interest has emerged in this phenomenon as a possible biological marker for individuals who are likely to benefit from tailo...


    pub_type: 杂志文章,随机对照试验


    authors: McClure EB,Adler A,Monk CS,Cameron J,Smith S,Nelson EE,Leibenluft E,Ernst M,Pine DS

    更新日期:2007-03-01 00:00:00

  • Effects of caffeine on discrimination learning, consolidation, and learned behavior in mice.

    abstract::Three sets of experiments were carried out in a Y water maze in which mice had to swim toward the light or the dark, in two different procedures. The first procedure involved, orientation toward a light source (L procedure), corresponding to natural preference, the latter involved orientation toward the dark (D proced...


    pub_type: 杂志文章


    authors: Castellano C

    更新日期:1976-08-17 00:00:00

  • Haloperidol and clozapine have dissociable effects in a model of attentional performance deficits induced by blockade of NMDA receptors in the mPFC.

    abstract:RATIONALE:Cognitive impairment in schizophrenia is particularly evident in the domains of attention and executive functions. Atypical antipsychotics are somewhat more effective than conventional antipsychotics in improving cognitive functioning in these patients. OBJECTIVE:The aim of this study was to compare the effe...


    pub_type: 杂志文章


    authors: Baviera M,Invernizzi RW,Carli M

    更新日期:2008-02-01 00:00:00

  • Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.

    abstract:BACKGROUND AND RATIONALE:Nicotinic acetylcholine systems play major roles in cognitive function. Nicotine and a variety of nicotinic agonists improve attention, and nicotinic antagonist exposure impairs it. This study was conducted to investigate the effect of a novel nicotinic receptor agonist at α4β2 nicotinic recept...


    pub_type: 杂志文章


    authors: Rezvani AH,Cauley MC,Johnson EC,Gatto GJ,Levin ED

    更新日期:2012-10-01 00:00:00

  • Effect of D-cycloserine and valproic acid on the extinction of reinstated fear-conditioned responses and habituation of fear conditioning in healthy humans: a randomized controlled trial.

    abstract:RATIONALE:Although the effects of D: -cycloserine (DCS) and valproic acid (VPA) on the facilitation of the extinction of fear-conditioned memory have been elucidated in animals, these effects have not been clearly confirmed in humans. OBJECTIVE:This study aimed to determine the effect of DCS (100 mg) and VPA (400 mg) ...


    pub_type: 杂志文章,随机对照试验


    authors: Kuriyama K,Honma M,Soshi T,Fujii T,Kim Y

    更新日期:2011-12-01 00:00:00

  • The discriminative stimulus properties of cocaine: effects of microinfusion of cocaine, a 5-HT1A agonist or antagonist, into the ventral tegmental area.

    abstract::Serotonin (5-HT) afferents may modulate the dopamine mesoaccumbens circuit, which has been shown to be critically involved in the locomotor stimulatory, discriminative stimulus, and rewarding properties of cocaine. In the present study, we investigated the role of 5-HT1A receptors in the ventral tegmental area (VTA) i...


    pub_type: 杂志文章


    authors: De La Garza R 2nd,Callahan PM,Cunningham KA

    更新日期:1998-05-01 00:00:00

  • Chlordiazepoxide-induced disruption of discrimination behaviour: a signal detection analysis.

    abstract::To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/r...


    pub_type: 杂志文章


    authors: Francis RL,Cooper SJ

    更新日期:1979-06-21 00:00:00

  • Oral administration of NNC 756--a placebo controlled PET study of D1-dopamine receptor occupancy and pharmacodynamics in man.

    abstract::NNC 756 is a new benzazepine with high affinity and selectivity for D1-dopamine receptors. In a double-blind, placebo controlled, cross-over study, positron emission tomography and the radioligand [11C]SCH 23390 were used to determine central D1-dopamine receptor occupancy after a single oral dose of 80 mg NNC 756 in ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Karlsson P,Farde L,Halldin C,Sedvall G,Ynddal L,Sloth-Nielsen M

    更新日期:1995-05-01 00:00:00

  • Inhibitory influences of the adrenal steroid, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone [correction of tetrahydroxycorticosterone] on aggression and defeat-induced analgesia in mice.

    abstract::The effects of intraperitoneal administrations of the deoxycorticosterone metabolite, 5 alpha-pregnane-, 21 diol-20-one (3 alpha, 5 alpha-tetrahydrodeoxycorticosterone; alpha-THDOC) on the responses to aggression and defeat-induced analgesia were examined in subordinate intruder male mice in "resident-intruder" pairin...


    pub_type: 杂志文章


    authors: Kavaliers M

    更新日期:1988-01-01 00:00:00

  • Chronic exposure to cocaine is associated with persistent behavioral disturbances. A cross-sectional dimensional study in outpatients with multiple substance use disorders.

    abstract:RATIONALE:Behavioral disturbances (BD) are prevalent in patients with substance use disorders (SUD). OBJECTIVES:To test the hypothesis that chronic exposure to cocaine could favor the acquisition of BD that were not present in childhood. METHODS:We used child and adult ADHD self-report screening scales (WURS-25 and A...


    pub_type: 杂志文章


    authors: Vorspan F,de Witt P,Zerdazi EH,Karsinti E,Ksouda K,Icick R,Bellivier F,Marie N,Brousse G,Bloch V

    更新日期:2020-11-01 00:00:00

  • The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat.

    abstract:RATIONALE:Anticipatory nausea (AN) experienced by chemotherapy patients is resistant to current anti-nausea treatments. In this study, the effect of manipulation of the endocannabinoid (EC) system on a rat model of nausea (conditioned gaping) was determined. OBJECTIVE:The potential of cannabidiol (CBD) and the fatty a...


    pub_type: 杂志文章


    authors: Rock EM,Limebeer CL,Mechoulam R,Piomelli D,Parker LA

    更新日期:2008-02-01 00:00:00