Predictable individual differences in the initiation of cocaine self-administration by rats under extended-access conditions are dose-dependent.

abstract：RATIONALE AND OBJECTIVES:Blood oxygen level dependent (BOLD) contrast pharmacological magnetic resonance imaging (phMRI) is an increasingly popular technique that allows the non-invasive investigation of spatial and temporal changes in rat brain function in response to pharmacological stimulation in vivo. Rat brain BOL...

journal_title：Psychopharmacology

authors： Steward CA,Marsden CA,Prior MJ,Morris PG,Shah YB

更新日期：2005-08-01 00:00:00

abstract：:Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...

journal_title：Psychopharmacology

authors： Yasui-Furukori N,Kondo T,Mihara K,Inoue Y,Kaneko S

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:Previous work has shown that environmental enrichment alters amphetamine-induced locomotor activity and conditioned place preference. OBJECTIVE:The present study examined the effect of environmental enrichment on amphetamine self-administration. METHODS:Female and male rats were raised from 21 days of age i...

journal_title：Psychopharmacology

authors： Bardo MT,Klebaur JE,Valone JM,Deaton C

更新日期：2001-05-01 00:00:00

abstract：:In a placebo-controlled study, we investigated the influence of nicotine on late-day aviation performance in 15 non-smoking subjects. In a within-subjects design, subjects were tested on 2 days, each lasting 8 h and consisting of three 75-min simulator flights (late-afternoon practice, evening test, night test). Prior...

journal_title：Psychopharmacology

authors： Mumenthaler MS,Taylor JL,O'Hara R,Yesavage JA

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...

journal_title：Psychopharmacology

authors： Nagaraja N,Andrade C,Sudha S,Madan Singh N,Chandra JS,Venkataraman BV

更新日期：2007-01-01 00:00:00

abstract：RATIONALE:New research findings in the field of neuroactive steroids strongly suggest that to understand their role in physiopathology, it is essential to accurately measure their tissue levels. Through his broad chemical expertise and extensive knowledge of steroids, Dr. Robert H. Purdy pioneered structure-activity re...

journal_title：Psychopharmacology

authors： Vallée M

更新日期：2014-09-01 00:00:00

abstract：RATIONALE:A previously reported pharmacokinetic interaction between bromperidol and carbamazepine, an inducer of cytochrome P450 (CYP) 3A4, suggests possible involvement of CYP3A4 in the metabolism of bromperidol. OBJECTIVE:We investigated pharmacokinetic interaction between bromperidol and itraconazole, a potent inhi...

journal_title：Psychopharmacology

authors： Furukori H,Kondo T,Yasui N,Otani K,Tokinaga N,Nagashima U,Kaneko S,Inoue Y

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...

journal_title：Psychopharmacology

authors： Jensen KP,Valentine G,Gueorguieva R,Sofuoglu M

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed. OBJECTIVES:We investigated the effects of baclofen (study 1) and mirtazapine (study 2) in a human laboratory model of marijuana intoxication, withdrawa...

journal_title：Psychopharmacology

authors： Haney M,Hart CL,Vosburg SK,Comer SD,Reed SC,Cooper ZD,Foltin RW

更新日期：2010-08-01 00:00:00

abstract：:The protective effects of acute and chronic diazepam administration (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) and picrotoxin were investigated. Considering the incidence of tonic-clonic convulsions, tolerance to the protective effects of diazepam was evident by day 5 if the mice were challenged wi...

journal_title：Psychopharmacology

authors： File SE

更新日期：1983-01-01 00:00:00

abstract：:In the studies reported here, we investigated the effects of nicotine on memory for unrelated word lists. Nicotine was delivered through cigarette smoking, and memory performance was assessed using both intentional and incidental recall tasks, and employing an additional, indirect measure of memory. We report the resu...

journal_title：Psychopharmacology

authors： Rusted J,Graupner L,Warburton D

更新日期：1995-06-01 00:00:00

abstract：:The benzodiazepine diazepam and the benzodiazepine antagonist Ro 15-1788 were tested alone or in combination for their influence on scopolamine-induced locomotor stimulation in mice. The benzodiazepine antagonist had no effect by itself, but prevented the enhancement of scopolamine-induced locomotor stimulation produc...

journal_title：Psychopharmacology

authors： Sansone M

更新日期：1982-01-01 00:00:00

abstract：:Sibutramine hydrochloride, a novel monoamine reuptake inhibitor antidepressant, has been studied to determine whether it alters dopaminergic function in the brain. Its effects have been compared with bupropion, a dopamine reuptake inhibitor, and methamphetamine, a dopamine reuptake inhibitor and releasing agent. Sibut...

journal_title：Psychopharmacology

authors： Heal DJ,Frankland AT,Gosden J,Hutchins LJ,Prow MR,Luscombe GP,Buckett WR

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Antidepressants are known to modify human sleep patterns. OBJECTIVES:Duloxetine is a new antidepressant with a mechanism of action involving reuptake inhibition of both serotonin (5-HT) and norepinephrine (NE). In this study, the effects of two dosing regimens of duloxetine on sleep electroencephalography (E...

journal_title：Psychopharmacology

authors： Chalon S,Pereira A,Lainey E,Vandenhende F,Watkin JG,Staner L,Granier LA

更新日期：2005-02-01 00:00:00

abstract：:The influence of practice while under intoxication was tested on the development of acute tolerance to the motor impairment effect of ethanol. In experiment 1, the motor impairment effect induced by an IP injection of 1.8 g/kg ethanol was quantified after various intervals in separate groups of animals. Lower impairme...

journal_title：Psychopharmacology

authors： Lê AD,Kalant H

更新日期：1992-01-01 00:00:00

abstract：:The noradrenergic system has repeatedly been implicated in the mediation of attentional processes. Using a double-blind, placebo-controlled design, the present investigation examines the effects of two doses (1.5 micrograms/kg and 2.5 micrograms/kg) of the alpha 2 adrenoceptor agonist clonidine (CLO) on performance of...

journal_title：Psychopharmacology

authors： Coull JT,Middleton HC,Robbins TW,Sahakian BJ

更新日期：1995-08-01 00:00:00

abstract：:Acute (50.0 mg/kg) and repeated (0.1-10.0 mg/kg) administration of dihydroergosine (DHESN) to rats over 5 days lowered the concentration of 5-HIAA in the brain. DHESN given acutely increased the brain 5-HT in p-CPA-treated animals and diminished the probenecid-induced increase in brain 5-HIAA. In pargyline-treated rat...

journal_title：Psychopharmacology

authors： Pericić D,Manev H,Levanat S,Jernej B,Vujić D,Djordjević N

更新日期：1986-01-01 00:00:00

abstract：:Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that i...

journal_title：Psychopharmacology

authors： Walker MJ,Poulos CX,Le AD

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:Environmental context has been shown to influence responding under multiple schedules of food reinforcement and to modify the behavioral effects of drugs. However, no systematic study has been conducted under conditions of cocaine self-administration. The hypothesis was that changes in the magnitude of food r...

journal_title：Psychopharmacology

authors： Nader MA,Sinnott RS,Mach RH,Morgan D

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Alcoholics report persistent alcohol craving that is heightened by cognitive cues, stressful situations, and abstinence. The role of endogenous cannabinoids in human alcohol craving--though long suspected--remains elusive. MATERIALS AND METHODS:We employed laboratory exposure to stress, alcohol cue, and neu...

journal_title：Psychopharmacology

authors： Mangieri RA,Hong KI,Piomelli D,Sinha R

更新日期：2009-07-01 00:00:00

abstract：:SCH 39166 is the first selective D1-dopamine receptor antagonist developed for clinical trials in schizophrenia. SCH 39166 was evaluated as a radioligand for PET, labeled with 11C, and as a D1-dopamine receptor antagonist after single oral doses in healthy men. After intravenous injection of [11C]SCH 39166 distributio...

journal_title：Psychopharmacology

authors： Karlsson P,Sedvall G,Halldin C,Swahn CG,Farde L

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:(+/-) 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine analog and drug of abuse. In animals, MDMA damages brain serotonin (5-HT) neurons at doses that overlap with those used recreationally by some humans. To date, few functional sequelae of MDMA-induced 5-HT damage have been identified. ...

journal_title：Psychopharmacology

authors： McCann UD,Mertl M,Eligulashvili V,Ricaurte GA

更新日期：1999-04-01 00:00:00

abstract：RATIONALE:Rivastigmine patches are used for patients with Alzheimer's disease (AD), but little is known about the serum concentration of rivastigmine and its metabolite or clinical adherence in relation to skinfold thickness after rivastigmine patch application. OBJECTIVES:The aim of this study was to examine the asso...

journal_title：Psychopharmacology

authors： Chou PS,Jhang KM,Huang LC,Wang WF,Yang YH

更新日期：2019-04-01 00:00:00

abstract：RATIONALE:Animal models aimed to mimic mania have in common the lack of genuine affective parameters. Although rodent amphetamine-induced hyperlocomotion is a frequently used behavioral model of mania, locomotor activity is a rather unspecific target for developing new pharmacological therapies, and does not necessaril...

journal_title：Psychopharmacology

authors： Pereira M,Andreatini R,Schwarting RK,Brenes JC

更新日期：2014-07-01 00:00:00

abstract：:After initial exposure to 80 mg/kg, pigeons trained on a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40-160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of responses directed to the ethosuximide-appropriate ...

journal_title：Psychopharmacology

authors： Clark RD,Schlinger H,Poling A

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reins...

journal_title：Psychopharmacology

authors： Buczek Y,Lê AD,Wang A,Stewart J,Shaham Y

更新日期：1999-05-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) and locomotor activity have been used to investigate the effects of antipsychotic and stimulant drugs and their underlying dopaminergic mechanisms. Whereas D2-like agonists consistently decreased PPI and increased locomotion in rats in previous studies, we recently reported that thes...

journal_title：Psychopharmacology

authors： Ralph RJ,Caine SB

更新日期：2007-04-01 00:00:00

abstract：:Serotonergic mechanisms mediate the expression of personality traits (such as impulsivity, aggression and anxiety) that are linked to vulnerability to psychological illnesses, and modulate the identification of emotional expressions in the face as well as learning about broader classes of appetitive and aversive signa...

journal_title：Psychopharmacology

authors： Ward R,Sreenivas S,Read J,Saunders KEA,Rogers RD

更新日期：2017-07-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Previous studies have demonstrated that sensitization to repeated doses of cocaine results in prolonged changes in glutamate transmission. However, little is known about long-term changes in glutamate transmission following a single dose of cocaine. Our laboratory has previously reported that a...

journal_title：Psychopharmacology

authors： Kozell B,Meshul K

更新日期：2003-02-01 00:00:00

abstract：:This study was designed to compare the therapeutic and adverse effects of tranylcypromine (a monoamine oxidase inhibitor), nortriptyline (a tricyclic antidepressant), and placebo. A total of 122 depressed outpatients randomly assigned to double-blind treatment with one of these agents completed the 4-week protocol. Tr...

journal_title：Psychopharmacology

authors： White K,Razani J,Cadow B,Gelfand R,Palmer R,Simpson G,Sloane RB

更新日期：1984-01-01 00:00:00