Scopolamine-induced locomotor stimulation in mice: effect of diazepam and a benzodiazepine antagonist.

abstract：:The pharmacokinetics of flumazenil in the rat were determined after 2.5 mg/kg intravenous and 25 mg/kg oral administration. Following intravenous administration flumazenil was rapidly eliminated with an extremely short terminal half-life (mean +/- SE, n = 8) of 8.3 +/- 0.3 min due to a large total blood clearance of 1...

journal_title：Psychopharmacology

authors： Mandema JW,Gubbens-Stibbe JM,Danhof M

更新日期：1991-01-01 00:00:00

abstract：:The name of Hayley Treloar Padovano was incorrectly tagged in the original version of this article. Instead of Padovano as family name and Hayley Treloar as given name, it should be Hayley as given name and Treloar Padovano as family name. Correct presentation of author name when online should be Treloar Padovano H. ...

journal_title：Psychopharmacology

authors： Mereish EH,Treloar Padovano H,Wemm S,Miranda R Jr

更新日期：2018-09-01 00:00:00

abstract：RATIONALE:Performance on progressive ratio schedules has been proposed as a means of assessing the effects of drugs on the value or "efficacy" of reinforcers. A mathematical model affords a basis for quantifying the effects of drugs on progressive ratio schedule performance. According to this model, the relation betwee...

journal_title：Psychopharmacology

authors： Zhang Z,Rickard JF,Asgari K,Body S,Bradshaw CM,Szabadi E

更新日期：2005-05-01 00:00:00

abstract：:Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...

journal_title：Psychopharmacology

authors： Brown CRH,Duka T,Forster S

更新日期：2018-07-01 00:00:00

abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Rice KC,Traynor JR,Woods JH

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:The purpose of the present investigation was to evaluate the effects of the D3 agonist (+/-)-7-hydroxy-dipropylaminotetralin (7-OH-DPAT), various dopamine (DA) agonists and DA antagonists on the antinociceptive effects of mu opioids. METHODS:Antinociception was assessed using a warm-water tail-withdrawal pro...

journal_title：Psychopharmacology

authors： Cook CD,Rodefer JS,Picker MJ

更新日期：1999-06-01 00:00:00

abstract：:In the conditioned reinforcement paradigm, animals learn a new instrumental response reinforced solely by conditioned reward (a stimulus that has previously been associated with primary reward). It has been shown that psychostimulants potentiate responding for conditioned reward and there is evidence that the nucleus ...

journal_title：Psychopharmacology

authors： Kelley AE,Delfs JM

更新日期：1991-01-01 00:00:00

abstract：INTRODUCTION:Dysfunction of brain dopamine systems is involved in various neuropsychiatric disorders. Challenge studies with dopamine receptor agonists have been performed to assess dopamine receptor functioning, classically using the release of growth hormone (GH) from the hindbrain as primary outcome measure. The obj...

journal_title：Psychopharmacology

authors： Schellekens AF,Grootens KP,Neef C,Movig KL,Buitelaar JK,Ellenbroek B,Verkes RJ

更新日期：2010-01-01 00:00:00

abstract：RATIONALE:Training in research ethics is crucial for psychiatric investigators. Addressing ethical dimensions of human subjects research requires knowledge about the rules and norms governing research; sensitivity to ethical implications of actions; and skills in ethics problem solving. Investigators in training who ar...

journal_title：Psychopharmacology

authors： Chen DT

更新日期：2003-12-01 00:00:00

abstract：:Peak saccadic eye movement velocity (SEV) and average smooth pursuit gain (SP) are reduced in a dose-dependent manner by diazepam and provide reliable, quantitative measures of benzodiazepine agonist effects. To evaluate the specificity of these eye movement effects for agents acting at the central GABA-benzodiazepine...

journal_title：Psychopharmacology

authors： Hopfenbeck JR,Cowley DS,Radant A,Greenblatt DJ,Roy-Byrne PP

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...

journal_title：Psychopharmacology

authors： McClenahan SJ,Gunnell MG,Owens SM,Fantegrossi WE

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND RATIONALE:Epidemiological evidence suggests that people who begin experimenting with drugs of abuse during early adolescence are more likely to develop substance use disorders (SUDs), but this correlation does not guarantee causation. Animal models, in which age of onset can be tightly controlled, offer ...

journal_title：Psychopharmacology

authors： Schramm-Sapyta NL,Walker QD,Caster JM,Levin ED,Kuhn CM

更新日期：2009-09-01 00:00:00

abstract：:The effects of diazepam (10 mg orally) on the responding of normal human volunteers was studied in a procedure that involved the maintenance of operant behavior by monetary reinforcement and its suppression by monetary loss (punishment). Diazepam produced an antipunishment effect as shown by an increase in behavior su...

journal_title：Psychopharmacology

authors： Carlton PL,Siegel JL,Murphree HB,Cook L

更新日期：1981-01-01 00:00:00

abstract：:Various dopamine receptor antagonists have divergent clinical and neurochemical properties. The relative ability of anticholinergics (benztropine and scopolamine) to reverse these drugs was assessed in squirrel monkeys and rats performing a Sidman avoidance task. In monkeys, benztropine markedly attenuated the effects...

journal_title：Psychopharmacology

authors： Liebman JM,Neale R,Noreika L,Braunwalder A

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Carbon monoxide synthetized by inducible heme oxygenase (HO-1) exerts potent anti-inflammatory and antinociceptive effects during acute and neuropathic pain, but its role in the modulation of chronic inflammatory pain and the possible involvement of nitric oxide in this action remain unknown. OBJECTIVES AND ...

journal_title：Psychopharmacology

authors： Negrete R,Hervera A,Leánez S,Pol O

更新日期：2014-03-01 00:00:00

abstract：RATIONALE:Marijuana and alcohol, when used separately and in combination, contribute to automobile accidents and failed sobriety tests of standing balance. However, the extent to which the drugs have additive effects on both of these measures is unknown. OBJECTIVES:This study was designed to compare directly the separ...

journal_title：Psychopharmacology

authors： Liguori A,Gatto CP,Jarrett DB

更新日期：2002-10-01 00:00:00

abstract：:The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml i.v.) or received yok...

journal_title：Psychopharmacology

authors： Fuchs RA,Tran-Nguyen LT,Specio SE,Groff RS,Neisewander JL

更新日期：1998-01-01 00:00:00

abstract：RATIONALE:Treatment of attention-deficit/hyperactivity disorder (ADHD) has for many years relied on psychostimulants, particularly various formulations of amphetamines and methylphenidate. These are central nervous system stimulants and are scheduled because of their abuse potential. Atomoxetine (atomoxetine hydrochlor...

journal_title：Psychopharmacology

authors： Upadhyaya HP,Desaiah D,Schuh KJ,Bymaster FP,Kallman MJ,Clarke DO,Durell TM,Trzepacz PT,Calligaro DO,Nisenbaum ES,Emmerson PJ,Schuh LM,Bickel WK,Allen AJ

更新日期：2013-03-01 00:00:00

abstract：RATIONALE:Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapi...

journal_title：Psychopharmacology

authors： Lew R,Constantinescu CC,Holden D,Carson RE,Carroll V,Galluppi G,Koblan KS,Hopkins SC

更新日期：2020-11-01 00:00:00

abstract：:Rats were treated once with doses of haloperidol or of droperidol below and above the acute ID50 vs the dopamine agonist apomorphine; they were later challenged with an acute dose of apomorphine (0.3 mg/kg, SC) and rated for stereotyped behavioral responses. The two neuroleptics were similar in acute anti-apomorphine ...

journal_title：Psychopharmacology

authors： Campbell A,Baldessarini RJ,Teicher MH,Kula NS

更新日期：1985-01-01 00:00:00

abstract：:This study compared the efficacy of buprenorphine to methadone for decreasing cocaine use in patients with combined opioid and cocaine use. Participants (n = 51) were enrolled in a 26-week treatment program and randomly assigned to either buprenorphine or methadone. Dosing was double-blind and double-dummy. Patients w...

journal_title：Psychopharmacology

authors： Strain EC,Stitzer ML,Liebson IA,Bigelow GE

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:Previous behavioral and biochemical studies suggest that allosteric coupling processes initiated by benzodiazepines, barbiturates and neuroactive steroids can be sub-categorized on the basis of their sensitivities to antagonism by increased atmospheric pressure. However, biochemical evidence supporting this h...

journal_title：Psychopharmacology

authors： Davies DL,McCauley LD,Bolger MB,Alkana RL

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the rel...

journal_title：Psychopharmacology

authors： Yasuno F,Suhara T,Okubo Y,Sudo Y,Inoue M,Ichimiya T,Tanada S

更新日期：2001-02-01 00:00:00

abstract：:The present study was undertaken to investigate thoroughly the preclinical psychopharmacological profile of venlafaxine, testing a wide range of doses in animal models indicative of antidepressant-like effects. Venlafaxine was found to be active in mouse forced swimming test (at 8, 16, 32 and 64 mg/kg) and to increase...

journal_title：Psychopharmacology

authors： Redrobe JP,Bourin M,Colombel MC,Baker GB

更新日期：1998-07-01 00:00:00

abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...

journal_title：Psychopharmacology

authors： Monteleone P,Iovino M,Orio F,Steardo L

更新日期：1987-01-01 00:00:00

abstract：:Using a 15-s intershock interval, an increase in shock-induced fighting was observed following intraventricular 96 microgram 5,7-dihydroxytryptamine (5,7-DHT) and 90 microgram 6-hydroxydopa (6-OHdopa). The incidence of predatory mouse killing was enhanced by 5,7-DHT, but was not affected by 6-OHdopa. Pain sensitivity ...

journal_title：Psychopharmacology

authors： Kantak KM,Hegstrand LR,Eichelman B

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Alzheimer disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly. A combination of cholinergic and glutamatergic dysfunction appears to underlie the symptomatology of AD, and thus, treatment strategies should address impairments in both systems. Evidence sugges...

journal_title：Psychopharmacology

authors： Schaeffer EL,Gattaz WF

更新日期：2008-05-01 00:00:00

abstract：:The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various an...

journal_title：Psychopharmacology

authors： Ramanathan M,Jaiswal AK,Bhattacharya SK

更新日期：1998-02-01 00:00:00

abstract：:Rats were trained in a Y-maze on a two-choice simultaneous black-white discrimination with either black or white as S+. Animals were then transferred to one of three discrimination tasks. In task 1 (New S-), a new stimulus, either vertical or horizontal stripes, was substituted for the original S-. In task 2 (New S+),...

journal_title：Psychopharmacology

authors： Weiner I,Feldon J,Ben-Horin E

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Relapse to drug-seeking in abstinent heroin addicts and reinstatement in experimental animals are observed when exposed to drug-associated stimuli or cues, the drug itself, and stressful events. It has been shown that footshock-induced stress increases the rewarding effects of opiates, delays extinction, and ...

journal_title：Psychopharmacology

authors： Ribeiro Do Couto B,Aguilar MA,Manzanedo C,Rodríguez-Arias M,Armario A,Miñarro J

更新日期：2006-05-01 00:00:00