Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme.

abstract：RATIONALE:The purpose of the present investigation was to evaluate the effects of the D3 agonist (+/-)-7-hydroxy-dipropylaminotetralin (7-OH-DPAT), various dopamine (DA) agonists and DA antagonists on the antinociceptive effects of mu opioids. METHODS:Antinociception was assessed using a warm-water tail-withdrawal pro...

journal_title：Psychopharmacology

authors： Cook CD,Rodefer JS,Picker MJ

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...

journal_title：Psychopharmacology

authors： Albelda N,Bar-On N,Joel D

更新日期：2010-05-01 00:00:00

abstract：:The effects of four indirect dopamine agonists, d-amphetamine (0.25-4.0 mg/kg), cocaine (2.5-40.0 mg/kg), GBR 12909 (10.0-30.0 mg/kg), and nomifensine (5.0-20.0 mg/kg), on the behavioral organization of movements in an unconditioned motor paradigm were investigated in rats. The extended scaling hypothesis using the fl...

journal_title：Psychopharmacology

authors： Paulus MP,Callaway CW,Geyer MA

更新日期：1993-01-01 00:00:00

abstract：:Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...

journal_title：Psychopharmacology

authors： Yasui-Furukori N,Kondo T,Mihara K,Inoue Y,Kaneko S

更新日期：2004-01-01 00:00:00

abstract：:Three recently arrived drug naive Cebus apella monkeys with "spontaneous" stereotyped oral movements were treated with apomorphine and haloperidol using a wide dose range. Low doses of apomorphine (0.05-0.1 mg/kg) suppressed the oral stereotypies without affecting normal behaviour such as grooming and scratching. High...

journal_title：Psychopharmacology

authors： Korsgaard S,Povlsen UJ,Randrup A

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Exposure to a single session of uncontrollable inescapable shock (IS), but not to identical controllable escapable shock, produces a potentiation of morphine's rewarding properties that is unusual in that the stressor can be given a number of days before the drug administration in an environment quite differe...

journal_title：Psychopharmacology

authors： Will MJ,Der-Avakian A,Bland ST,Grahn RE,Hammack SE,Sparks PD,Pepin JL,Watkins LR,Maier SF

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:It has been reported that in panic disorder (PD), tryptophan depletion enhances the vulnerability to experimentally induced panic, while the administration of serotonin precursors blunts the response to challenges. OBJECTIVES:Using a high-dose carbon dioxide (CO(2)) challenge, we aimed to investigate the eff...

journal_title：Psychopharmacology

authors： Colasanti A,Esquivel G,den Boer E,Horlings A,Dandachi A,Oostwegel JL,van Donkelaar EL,Griez EJ,Schruers K

更新日期：2011-06-01 00:00:00

abstract：RATIONALE:Stressful life events are suggested to contribute to the development of various pathologies, such as cardiovascular disorders, whose etiopathogenesis is highly associated with elevated levels of serum amyloid A (SAA) proteins. SAA synthesis in the liver is regulated by a complex network of cytokines acting in...

journal_title：Psychopharmacology

authors： Konstandi M,Sotiropoulos I,Matsubara T,Malliou F,Katsogridaki A,Andriopoulou CE,Gonzalez FJ

更新日期：2019-06-01 00:00:00

abstract：RATIONALE:The experience of strong traumata leads to the formation of enduring fear memories that may degenerate into post-traumatic stress disorder. One of the most successful treatments for this condition consists of extinction training during which the repeated exposure to trauma-inducing stimuli in a safe environme...

journal_title：Psychopharmacology

authors： Silva BA,Burns AM,Gräff J

更新日期：2019-01-01 00:00:00

abstract：RATIONALE:The rapid membrane actions of neuroactive steroids, particularly via an enhancement of γ-aminobutyric acidA receptors (GABAARs), participate in the regulation of central nervous system excitability. Prior evidence suggests an inverse relationship between endogenous GABAergic neuroactive steroid levels and beh...

journal_title：Psychopharmacology

authors： Snelling C,Tanchuck-Nipper MA,Ford MM,Jensen JP,Cozzoli DK,Ramaker MJ,Helms M,Crabbe JC,Rossi DJ,Finn DA

更新日期：2014-09-01 00:00:00

abstract：RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...

journal_title：Psychopharmacology

authors： Mada S,Gerak LR,Soyer A,Maguire DR,Hu Z,Minervini V,Cunningham CW,France CP

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...

journal_title：Psychopharmacology

authors： Barbano MF,Cador M

更新日期：2007-04-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...

journal_title：Psychopharmacology

authors： Larrauri JA,Burke DA,Hall BJ,Levin ED

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Stress experience during adolescence has been linked to the development of psychiatric disorders in adulthood, many of which are associated with impairments in prefrontal cortex function. OBJECTIVE:The current study was designed to determine the immediate and enduring effects of repeated social stress on a p...

journal_title：Psychopharmacology

authors： Snyder KP,Barry M,Valentino RJ

更新日期：2015-01-01 00:00:00

abstract：RATIONALE:Threatening social stimuli were used in this study as aversive conditions to test anxiety in lactating female mice. The odors of potential infanticidal males or the "stress odor" left by restrained mice represented two aversive conditions that have been suggested to modulate the time spent by the mothers to r...

journal_title：Psychopharmacology

authors： Mandillo S,D'Amato FR

更新日期：1999-10-01 00:00:00

abstract：:Acute (50.0 mg/kg) and repeated (0.1-10.0 mg/kg) administration of dihydroergosine (DHESN) to rats over 5 days lowered the concentration of 5-HIAA in the brain. DHESN given acutely increased the brain 5-HT in p-CPA-treated animals and diminished the probenecid-induced increase in brain 5-HIAA. In pargyline-treated rat...

journal_title：Psychopharmacology

authors： Pericić D,Manev H,Levanat S,Jernej B,Vujić D,Djordjević N

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...

journal_title：Psychopharmacology

authors： Baliño P,Ledesma JC,Aragon CM

更新日期：2014-12-01 00:00:00

abstract：:The purpose of this study was to assess the effects of acute nicotine administration, following a 12-h cigarette deprivation period, using a computerized performance assessment battery (PAB). The PAB was comprised of five tasks which were selected to reflect a variety of complex acquired behaviors, sometimes referred ...

journal_title：Psychopharmacology

authors： Snyder FR,Henningfield JE

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergi...

journal_title：Psychopharmacology

authors： Siciliano CA,Calipari ES,Yorgason JT,Lovinger DM,Mateo Y,Jimenez VA,Helms CM,Grant KA,Jones SR

更新日期：2016-04-01 00:00:00

abstract：:The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...

journal_title：Psychopharmacology

authors： Cohen RM,Pickar D,Garnett D,Lipper S,Gillin JC,Murphy DL

更新日期：1982-01-01 00:00:00

abstract：:Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevated m-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30-40%, but had no effect on m-cholinoceptor density in the frontal cortex of young (4 weeks) mice. The effect of piracetam on m-cholinoceptor density as...

journal_title：Psychopharmacology

authors： Pilch H,Müller WE

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found. MATERIALS AND METHODS:Here, we exa...

journal_title：Psychopharmacology

authors： Cippitelli A,Ayanwuyi LO,Barbier E,Domi E,Lerma-Cabrera JM,Carvajal F,Scuppa G,Li H,Ubaldi M,Heilig M,Roberto M,Ciccocioppo R

更新日期：2015-03-01 00:00:00

abstract：RATIONALE:A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents. OBJECTIVE:Our primary goal was to examine the putati...

journal_title：Psychopharmacology

authors： Calcagnoli F,de Boer SF,Althaus M,den Boer JA,Koolhaas JM

更新日期：2013-10-01 00:00:00

abstract：:The relationship between nicotine yield as determined by the FTC method and nicotine absorption was examined in 72 smokers in a more rigorous repetition of a previous study of 33 smokers. For this study, 113 smokers evenly distributed across four FTC "tar" yield ranges were recruited, only 72 demonstrated reasonable c...

journal_title：Psychopharmacology

authors： Byrd GD,Davis RA,Caldwell WS,Robinson JH,deBethizy JD

更新日期：1998-10-01 00:00:00

abstract：:Single oral and intramuscular (i.m.) doses of imipramine (IMI) were administered to four normal males. Serum and urine concentrations of IMI, desipramine (DMI) and their unconjugated 2-hydroxy metabolites were measured by high-pressure liquid chromatography (HPLC). Urinary conjugated 2-hydroxy metabolites were also me...

journal_title：Psychopharmacology

authors： Sutfin TA,DeVane CL,Jusko WJ

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:A previous study found that a 10-min bout of moderate intensity exercise reduced cigarette withdrawal symptoms and desire to smoke in sedentary smokers but the effect may have been due to participants focusing attention on physical activity rather than the activity itself. OBJECTIVES:This study examined the ...

journal_title：Psychopharmacology

authors： Daniel J,Cropley M,Ussher M,West R

更新日期：2004-07-01 00:00:00

abstract：:The relationship between norepinephrine (NE) content in cortex and spinal cord and acoustic startle amplitude was investigated in two experiments. Administration of diethyldithiocarbamate (DDC) depressed startle amplitude at the same time and dose that it most severely depleted NE content. These results support the co...

journal_title：Psychopharmacology

authors： Storm JE,Millington WR,Fechter LD

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Despite the critical role attributed to phosphorylated extracellular signal regulated kinase (pERK1/2) in the nucleus accumbens (Acb) in the actions of addictive drugs, the effects of morphine on ERK1/2 phosphorylation in this area are still controversial. OBJECTIVES:In order to investigate further this issu...

journal_title：Psychopharmacology

authors： Rosas M,Porru S,Fenu S,Ruiu S,Peana AT,Papale A,Brambilla R,Di Chiara G,Acquas E

更新日期：2016-08-01 00:00:00

abstract：RATIONALE:Previous work has shown that environmental enrichment alters amphetamine-induced locomotor activity and conditioned place preference. OBJECTIVE:The present study examined the effect of environmental enrichment on amphetamine self-administration. METHODS:Female and male rats were raised from 21 days of age i...

journal_title：Psychopharmacology

authors： Bardo MT,Klebaur JE,Valone JM,Deaton C

更新日期：2001-05-01 00:00:00

abstract：:There is an increasing prevalence of smokeless tobacco use. However, very little descriptive information is available on the pattern of use. This study examines topographical features of smokeless tobacco use in a male college-age population (N = 56). Subjects were required to use smokeless tobacco ad lib. for a perio...

journal_title：Psychopharmacology

authors： Hatsukami DK,Keenan RM,Anton DJ

更新日期：1988-01-01 00:00:00