Abstract:
RATIONALE:The purpose of the present investigation was to evaluate the effects of the D3 agonist (+/-)-7-hydroxy-dipropylaminotetralin (7-OH-DPAT), various dopamine (DA) agonists and DA antagonists on the antinociceptive effects of mu opioids. METHODS:Antinociception was assessed using a warm-water tail-withdrawal procedure in rats. RESULTS:The mu opioids morphine (0.3-10 mg/kg) and dezocine (0.03-3.0 mg/kg) produced dose-dependent increases in antinociception with maximal effects obtained at the higher doses tested. Pretreatment with the putative D3 agonist 7-OH-DPAT (1.0-10 mg/kg) produced a dose-dependent attenuation of the antinociceptive effects of morphine and dezocine. At the highest dose of 7-OH-DPAT tested, the morphine dose-effect curve was shifted rightward by approximately 1.5 log units and the dezocine curve by greater than 2.3 log units. The (+)-isomer of 7-OH-DPAT (1.0 and 3.0 mg/kg) also shifted the morphine dose-effect curve to the right in a dose-dependent manner. The DA D3/D2 agonist (-)-quinpirole (0.1-10mg/kg) attenuated the effects of morphine, but these effects were small in magnitude, not dose-dependent and observed only under a limited set of conditions. The DA D2/D3 antagonist spiperone failed to alter the morphine dose-effect curve, but reversed the effects of 7-OH-DPAT on morphine antinociception. Pretreatment with the DA D1 agonist (+/-)-SKF38393 (1.0 and 10 mg/kg) and the D1 antagonist (+)-SCH23390 (0.1 and 1.0 mg/kg) failed to alter the morphine dose-effect curve. CONCLUSION:The finding that 7-OH-DPAT markedly attenuated the effects of morphine and that these effects were reversed with spiperone suggests that activity at the D3, and possibly the D2, receptor can modulate mu agonist-induced antinociception.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Cook CD,Rodefer JS,Picker MJdoi
10.1007/s002130050999subject
Has Abstractpub_date
1999-06-01 00:00:00pages
239-47issue
3eissn
0033-3158issn
1432-2072journal_volume
144pub_type
杂志文章abstract::In order to assess the contribution of cerebellar effects of ethanol to the production of ataxia, "nervous" (nr/nr) and control (nr/+ or +/+) C3H mice were tested for locomotor ability 2 min after being given intraperitoneal ethanol injections. The nr/nr mice suffer from loss of most of their cerebellar Purkinje cells...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00423259
更新日期:1976-07-28 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244407
更新日期:1990-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2007-11-01 00:00:00
abstract::Acute alcohol intoxication disrupts memory acquisition in humans and laboratory animals. This review summarizes recent behavioral and immediate early gene expression studies addressing the mechanisms of this phenomenon. Most behavioral investigations agree that the amnestic effect of alcohol is due to its preferential...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050687
更新日期:1998-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179193
更新日期:1986-01-01 00:00:00
abstract::The urinary excretion of 4-hydroxy-3-methoxyphenylglycol was compared in a group of 23 depressive patients and 27 control subjects of similar age. There was no difference between patients and controls although female controls excreted less than males. After 6 weeks' treatment with 150 mg daily of amitriptyline there w...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427352
更新日期:1979-06-28 00:00:00
abstract:RATIONALE AND OBJECTIVE:Depression symptoms are now recognized to be the predominant cause of disability for bipolar disorder (BD) patients. The treatment strategies for the depressed phase of BD remain more anecdotal than data-based. Olanzapine has been investigated as an alternative to antidepressants and a mood stab...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3453-1
更新日期:2014-07-01 00:00:00
abstract::It is commonly believed that repeated exposures diminish the pleasurable effects of drugs and hence that pleasure must have only a minor role in addiction. In six experiments with rats, repeated exposures to amphetamine, morphine, or cocaine were found to enhance the drug-induced rewarding effect as measured by condit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00451687
更新日期:1989-01-01 00:00:00
abstract::The effects of the benzomorphan antagonist Mr 2266 and the selective delta-antagonist ICI 154,129 on the body weight gain of 6-day-old suckling rat pups was observed. Mr 2266 significantly reduced body weight gain in these animals, though ICI 154,129 had no affect on this variable. These findings suggest that mu- and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432046
更新日期:1984-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426711
更新日期:1977-05-09 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02180028
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1808-9
更新日期:2010-05-01 00:00:00
abstract::The discriminative stimulus effect of midazolam, a short-acting benzodiazepine, was used for testing the effects of drugs thought to act as antagonists at different sites in the proposed benzodiazepine receptor complex. Rats were trained in a standard two-bar operant conditioning procedure with food reinforcers delive...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310626
更新日期:1986-01-01 00:00:00
abstract::It has previously been shown that serotonergic [5-hydroxytryptamine (5-HT)] neurons of the median raphe nucleus (MR) are critically involved in the control of the hippocampal electroencephalogram (EEG). Activation of MR 5-HT neurons desynchronizes the hippocampal EEG, whereas inhibition of MR 5-HT activity produces hi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02311170
更新日期:1995-08-01 00:00:00
abstract:RATIONALE:Central CB1 cannabinoid receptors regulate anxiety-like and appetitive consummatory behaviors. Pharmacological antagonism/inverse-agonism of CB1 receptors increases anxiety and decreases appetitive behaviors; however, neither well-defined dose nor context dependence of these effects has been simultaneously as...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3042-8
更新日期:2013-08-01 00:00:00
abstract:RATIONALE:It has been proposed that cannabinoid-1 receptor inverse agonists might be effective for smoking cessation. We evaluated this hypothesis with the cannabinoid-1 receptor inverse agonist taranabant. METHODS:Adults who smoked > or =10 cigarettes a day for >1 year and had an expired CO level of > or =10 ppm part...
journal_title:Psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00213-010-1790-2
更新日期:2010-04-01 00:00:00
abstract::In the conditioned reinforcement paradigm, animals learn a new instrumental response reinforced solely by conditioned reward (a stimulus that has previously been associated with primary reward). It has been shown that psychostimulants potentiate responding for conditioned reward and there is evidence that the nucleus ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244202
更新日期:1991-01-01 00:00:00
abstract::This study was designed to compare the therapeutic and adverse effects of tranylcypromine (a monoamine oxidase inhibitor), nortriptyline (a tricyclic antidepressant), and placebo. A total of 122 depressed outpatients randomly assigned to double-blind treatment with one of these agents completed the 4-week protocol. Tr...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427786
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1991-8
更新日期:2011-03-01 00:00:00
abstract:RATIONALE:Nicotine infusions that are self-administered (contingent) or response-independent (noncontingent) increase lever pressing for a reinforcing nonpharmacological stimulus in rats, suggesting that in addition to primary reinforcement, nicotine self-administration may result from nicotine enhancing the reinforcem...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0454-8
更新日期:2007-02-01 00:00:00
abstract::The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control d...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428551
更新日期:1984-01-01 00:00:00
abstract::In a one-trial step-through passive avoidance task, pretraining administration of ethanol was shown to decrease the latencies to step through at both training (day 1) and testing (day 2) for both rats and mice. A detailed analysis of these effects showed that they differed from those reported previously by others. The...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00436101
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:There is an emerging body of evidence that implicates a crucial role of γ-aminobutyric acid subtype A (GABAA) receptors in modulating the rewarding effects of a number of abused drugs. Modulation of GABAA receptors may therefore represent a novel drug-class independent mechanism for the development of abuse t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4155-z
更新日期:2016-02-01 00:00:00
abstract::This study examined the role of the strychnine-insensitive glycine binding site of the NMDA receptor in prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is an operational measure of gating processes which normally lead to a diminished ASR when a startling stimulus is preceded by a weak pre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050220
更新日期:1997-03-01 00:00:00
abstract:RATIONALE:Tryptophan depletion is used to reduce central serotonergic function and to investigate its role in psychiatric illness. Despite widespread clinical use, its effects on serotonin (5-HT) receptors have not been well characterized. OBJECTIVE:The aim of this study was to examine the effect of acute (ATD) and ch...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0635-5
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000470
更新日期:2000-07-01 00:00:00
abstract::This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245224
更新日期:1994-01-01 00:00:00
abstract:RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5068-4
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Non-medical use of prescription opioids such as the mu opioid receptor (MOP-r) agonist oxycodone is a growing problem in the USA and elsewhere. There is limited information about oxycodone's impact on diverse gene systems in the brain. OBJECTIVES:The current study was designed to examine how chronic oxyco...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4657-y
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:Acute diazepam administration has been shown to decrease plasma cortisol levels consistent with decreased activity of the hypothalamic-pituitary-adrenal axis, especially in individuals experiencing stress. However, the effects of chronic diazepam treatment on cortisol have been less studied, and the relations...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-004-1974-8
更新日期:2005-02-01 00:00:00