Abstract:
RATIONALE:The experience of strong traumata leads to the formation of enduring fear memories that may degenerate into post-traumatic stress disorder. One of the most successful treatments for this condition consists of extinction training during which the repeated exposure to trauma-inducing stimuli in a safe environment results in an attenuation of the fearful component of trauma-related memories. While numerous studies have investigated the neural substrates of recent (e.g., 1-day-old) fear memory attenuation, much less is known about the neural networks mediating the attenuation of remote (e.g., 30-day-old) fear memories. Since extinction training becomes less effective when applied long after the original encoding of the traumatic memory, this represents an important gap in memory research. OBJECTIVES:Here, we aimed to generate a comprehensive map of brain activation upon effective remote fear memory attenuation in the mouse. METHODS:We developed an efficient extinction training paradigm for 1-month-old contextual fear memory attenuation and performed cFos immunohistochemistry and network connectivity analyses on a set of cortical, amygdalar, thalamic, and hippocampal regions. RESULTS:Remote fear memory attenuation induced cFos in the prelimbic cortex, the basolateral amygdala, the nucleus reuniens of the thalamus, and the ventral fields of the hippocampal CA1 and CA3. All these structures were equally recruited by remote fear memory recall, but not by the recall of a familiar neutral context. CONCLUSION:These results suggest that progressive fear attenuation mediated by repetitive exposure is accompanied by sustained neuronal activation and not reverted to a pre-conditioning brain state. These findings contribute to the identification of brain areas as targets for therapeutic approaches against traumatic memories.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Silva BA,Burns AM,Gräff Jdoi
10.1007/s00213-018-5000-ysubject
Has Abstractpub_date
2019-01-01 00:00:00pages
369-381issue
1eissn
0033-3158issn
1432-2072pii
10.1007/s00213-018-5000-yjournal_volume
236pub_type
杂志文章abstract::Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3-1.0 g/kg ethanol on spontan...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245271
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/s00213-007-1004-8
更新日期:2008-03-01 00:00:00
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更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/BF02245259
更新日期:1992-01-01 00:00:00
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更新日期:2000-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2003-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00426313
更新日期:1976-12-21 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051009
更新日期:1999-06-01 00:00:00
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更新日期:2013-02-01 00:00:00
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更新日期:1997-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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更新日期:2018-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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更新日期:1982-01-01 00:00:00