Abstract:
RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive behavior using the signal attenuation rat model of OCD. In this model, 'compulsive' behavior is induced by attenuating a signal indicating that a lever-press response was effective in producing food. METHODS:The NMDA antagonist, MK 801 (0.025-0.100 mg/kg) and the partial NMDA agonist, D-cycloserine (3-100 mg/kg) were administered to rats just before assessing their lever-press responding following signal attenuation (Experiments 1 and 2, respectively). Because the effects of signal attenuation are assessed under extinction conditions, drug doses that were effective in Experiments 1 and 2 were also tested in an extinction session of lever-press responding that was not preceded by signal attenuation (Experiment 3). RESULTS:Systemic administration of D: -cycloserine (15 mg/kg) selectively decreased compulsive lever pressing, whereas systemic administration of MK 801 did not affect compulsive lever-pressing but dramatically increased resistance to extinction. CONCLUSIONS:Activation of NMDA receptors may have an anti-compulsive effect in OCD patients.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Albelda N,Bar-On N,Joel Ddoi
10.1007/s00213-010-1808-9subject
Has Abstractpub_date
2010-05-01 00:00:00pages
13-24issue
1eissn
0033-3158issn
1432-2072journal_volume
210pub_type
杂志文章abstract::The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control d...
journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.1007/BF02244813
更新日期:1992-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1989-01-01 00:00:00
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