Abstract:
:The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice. Taurine in doses of 80-100 micrograms/mouse impaired acquisition of a single trial in passive avoidance performance, but protected mice from the learning impairment induced by hypoxia. Neither beta-alanine nor saccharose were able to mimic the effects of taurine. Taurine had no effect on amnesia induced by scopolamine injected intraperitoneally. Taurine protected against the onset of convulsions induced by hypoxia, while convulsions induced by pentylenetetrazole (PTZ) and hyperbaric oxygen were unaffected. The survival time of mice exposed to hypoxia was significantly increased by taurine treatment. These data suggest that taurine may play a role as an antihypoxic agent.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Malcangio M,Bartolini A,Ghelardini C,Bennardini F,Malmberg-Aiello P,Franconi F,Giotti Adoi
10.1007/BF00451681subject
Has Abstractpub_date
1989-01-01 00:00:00pages
316-20issue
3eissn
0033-3158issn
1432-2072journal_volume
98pub_type
杂志文章abstract::Interactions of amygdala kindling and drug effects were explored in two experiments. Pretreatment with cocaine (40 mg/kg, IP) for 10 days did not significantly affect the rate of amygdala kindling compared to saline or non-kindled controls. In contrast, daily amygdala kindling with 200 microA for 0.5 s for 20 days sub...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431655
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Cocaine and opioids are often co-abused. As yet, however, there is no clear evidence that the drugs interact to make the mixture a more effective reinforcer. OBJECTIVE:The present study examined the relative reinforcing potency and maximum effectiveness of the cocaine-opioid combination in monkeys given a ch...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2131-1
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:The aim of our study was to test whether ketamine produces an antidepressant effect in animal model of olfactory bulbectomy and assess the role of mammalian target of rapamycin (mTOR) pathway in ketamine's antidepressant effect. METHODS:Bulbectomized (OBX) rats and sham controls were assigned to four subgrou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4256-3
更新日期:2016-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427828
更新日期:1983-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Footshock stress reliably reinstates heroin seeking in rats, but the time course of the development of this effect following drug withdrawal is not known. Here we studied the effect of intermittent footshock stress on reinstatement of heroin seeking following different withdrawal periods (1-66 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100748
更新日期:2001-06-01 00:00:00
abstract::In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427573
更新日期:1983-01-01 00:00:00
abstract::N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439104
更新日期:1977-04-29 00:00:00
abstract:RATIONALE:Rats, like humans, are susceptible to the reinforcing effects of reward-related stimuli presented within a compound stimulus array, putatively analogous to the so-called near-miss effect. We have previously demonstrated using a rodent slot machine task (rSMT) that the reward expectancy these stimuli elicit is...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4355-1
更新日期:2016-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2643-y
更新日期:2012-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0492-2
更新日期:2006-11-01 00:00:00
abstract:RATIONALE:Nicotine increases glutamate release in the ventral tegmental area and the nucleus accumbens, and thus enhances dopamine neurotransmission in the mesolimbic system that has been implicated in mediating the rewarding effects of drugs. Metabotropic glutamate receptors 5 (mGluR5) are found in the nucleus accumbe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1432-z
更新日期:2003-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-007-0963-0
更新日期:2008-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00213-016-4215-z
更新日期:2016-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245415
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427106
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050481
更新日期:1998-01-01 00:00:00
abstract:RATIONALE:The exact behavioral nature of drug-induced reinstatement of drug seeking is still debated. As an incentive, the drug can have general facilitatory influences on appetitive behaviors. As an interoceptive stimulus, the drug can acquire discriminative properties and control behavior. OBJECTIVE:This study asses...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1083-1
更新日期:2008-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02246244
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1259-8
更新日期:2009-04-01 00:00:00
abstract::The relationship between norepinephrine (NE) content in cortex and spinal cord and acoustic startle amplitude was investigated in two experiments. Administration of diethyldithiocarbamate (DDC) depressed startle amplitude at the same time and dose that it most severely depleted NE content. These results support the co...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426383
更新日期:1984-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4709-3
更新日期:2017-11-01 00:00:00
abstract::The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431736
更新日期:1977-01-31 00:00:00
abstract:RATIONALE:Zotepine is an antipsychotic drug with proven efficacy for treatment of acute episodes of schizophrenia. Antipsychotic drugs also require to be effective in prevention of recurrence. OBJECTIVE:This trial was designed to compare the effects of zotepine and placebo in the prevention of recurrence of acute epis...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-06-01 00:00:00
abstract:RATIONALE:Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. OBJECTIVES:Here, we decided to investigate the possible role of the group III mGlu receptor ligands, LSP1-2111, the g...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2502-2
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Deep brain stimulation (DBS) has achieved substantial success as a treatment for movement disorders such as Parkinson's disease. The therapeutic efficacy and relative lack of serious side effects resulted in the expansion of DBS into the treatment of many other diseases, including obsessive-compulsive disorde...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-3214-6
更新日期:2013-10-01 00:00:00
abstract::Pigeons were trained to peck each of two response keys. Periods during which pecks on one key (the food key) produced access to grain according to a random-ratio 80 schedule alternated irregularly with periods during which food-key responses had no scheduled consequences (extinction). Both keys remained amber unless a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00422418
更新日期:1981-01-01 00:00:00
abstract::The subtype of dopamine (DA) receptors mediating the yawning response to DA agonists was determined in rats. Yawning was elicited both by the mixed D1-D2 agonist apomorphine and by the specific D2 agonist LY 171555, but not by the selective D1 agonist SKF 38393. Both apomorphine- and LY 171555-induced yawning were ant...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00518186
更新日期:1987-01-01 00:00:00