Abstract:
:Chronic nicotine infusion has been found in a series of studies in our laboratory to significantly improve choice accuracy of rats in the eight-arm radial maze. The current study was designed to compare the effects of chronic nicotine infusion on working and reference memory in a 16-arm radial maze. Nicotine was administered to female Sprague-Dawley rats at approximately 5 mg/kg per day SC via osmotic minipumps. Controls received saline infusions. Chronic nicotine infusion significantly lowered the number of working memory errors compared to controls, whereas the number of reference memory errors was not significantly affected. The modest nicotine-induced reduction in working memory errors was seen as a main effect over the 4 weeks of infusion, but the clearest effect was seen in weeks 3-4 of nicotine administration. For the 2 weeks after withdrawal, the nicotine effect was no longer evident. Acute D1 challenges were given with the D1 agonist dihydrexidine (0, 0.25, 0.5 and 1 mg/kg) and the D1 antagonist SCH 23390 (0, 0.005, 0.015 and 0.05 micrograms/kg) during weeks 3-4 of chronic nicotine administration and weeks 1-2 after withdrawal from nicotine. Dihydrexidine caused a modest dose-related increase in reference memory errors but not working memory errors in the nicotine-treated, but not the control rats. The D1 antagonist SCH 23390 caused a modest though significant decrease in reference memory errors but not working memory errors in the control, but not the nicotine-treated rats. The behavioral specificity of chronic nicotine infusion was demonstrated with selective improvement in working memory function. Pharmacological interactions were seen with chronic nicotine treatment increasing responsivity to D1 agonist and decreasing responsivity to a D1 antagonist with regard to reference memory. The mechanisms of this interaction are still undiscovered.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Levin ED,Kim P,Meray Rdoi
10.1007/BF02805971subject
Has Abstractpub_date
1996-09-01 00:00:00pages
25-30issue
1eissn
0033-3158issn
1432-2072journal_volume
127pub_type
杂志文章abstract::This paper reports the reduction of the concentration of the neuropeptide somatostatin in the CSF of patients with affective illness during treatment with the anticonvulsant carbamazepine. None of the other psychotropic agents used in this study similarly affected CSF somatostatin, although zimelidine appeared to incr...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00428416
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s002130051077
更新日期:1999-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-02-01 00:00:00
abstract:RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-016-4235-8
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247394
更新日期:1996-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050563
更新日期:1998-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100891
更新日期:2001-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00492355
更新日期:1977-08-16 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4675-9
更新日期:2017-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00176470
更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05704-8
更新日期:2021-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433021
更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2545-4
更新日期:2012-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1751-9
更新日期:2010-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050890
更新日期:1999-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212766
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-007-0938-1
更新日期:2008-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00443406
更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244221
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Alzheimer disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly. A combination of cholinergic and glutamatergic dysfunction appears to underlie the symptomatology of AD, and thus, treatment strategies should address impairments in both systems. Evidence sugges...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-008-1092-0
更新日期:2008-05-01 00:00:00
abstract:RATIONALE:Heavy ecstasy use in humans has been associated with cognitive impairments and changes in cognitive brain function supposedly due to damage to the serotonin system. There is concern that even a single dose of 3,4-methylenedioxymethamphetamine may be neurotoxic, but very little is known about the consequences ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0792-1
更新日期:2007-08-01 00:00:00
abstract:RATIONALE:Recent studies have suggested that the salutary actions of clozapine in schizophrenia may be due to selective activation of M(1) muscarinic receptors by clozapine and/or its major active metabolite N-desmethylclozapine. OBJECTIVE:We systematically tested this hypothesis by screening a large number of psychoa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2017-1
更新日期:2005-04-01 00:00:00
abstract::This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245224
更新日期:1994-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1850-6
更新日期:2004-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432855
更新日期:1978-04-11 00:00:00
abstract::On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050017
更新日期:2000-01-01 00:00:00
abstract:RATIONALE:Therapeutic efficacy of antidepressant drugs appears to be related to their ability in producing neuroadaptive changes that restore normal brain function. Activity-regulated cytoskeletal associated protein (Arc) is an effector immediate early gene that plays a fundamental role in activity-dependent neural pla...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1276-7
更新日期:2008-12-01 00:00:00