Abstract:
:The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system activation. In the present studies, the dependence of aversive properties of cocaine on activation of endogenous CRF systems has been evaluated in rats using taste conditioning and runway self-administration paradigms. Systemic cocaine administration (20 mg/kg i.p.) produced a conditioned saccharin aversion which was dose-dependently potentiated by central administration of the CRF receptor antagonist, D-phe CRF (12 41). In addition, i.v. cocaine administration (0.75 mg/kg per injection i.v.) produced runway goal-box avoidance and conditioned place avoidance responses which were significantly accelerated by CRF antagonist treatment. In contrast, CRF receptor stimulation using CRF itself abolished cocaine-induced increases in goal latency in the runway paradigm. This generalized involvement of CRF systems in cocaine-related motivational/associative states is consistent with the comprehensive role of CRF in mediating emotional responses to non-drug stressors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Heinrichs SC,Klaassen A,Koob GF,Schulteis G,Ahmed S,De Souza EBdoi
10.1007/s002130050563subject
Has Abstractpub_date
1998-04-01 00:00:00pages
247-55issue
3eissn
0033-3158issn
1432-2072journal_volume
136pub_type
杂志文章abstract::Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...
journal_title:Psychopharmacology
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doi:10.1007/s002130050852
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pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426525
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427650
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1288-3
更新日期:2008-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-09-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2000-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00174698
更新日期:1988-01-01 00:00:00
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doi:10.1007/s00213-017-4640-7
更新日期:2017-08-01 00:00:00
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更新日期:2005-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1979-03-14 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-02-01 00:00:00
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更新日期:2003-02-01 00:00:00
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更新日期:2003-05-01 00:00:00
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更新日期:2017-06-01 00:00:00
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更新日期:2011-06-01 00:00:00
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更新日期:2011-08-01 00:00:00
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更新日期:2010-12-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:1997-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439266
更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00