Abstract:
:The effects of the enantiomers of 3-PPP on the maintenance of conditioned avoidance responding (CAR) were studied. The weak classical dopamine (DA) agonist (+)-3-PPP failed to interfere with CAR at any dose tested (0.8-13.6 mg/kg). Low doses of the drug produced sedation, while high doses produced behavioural stimulation. (-)-3-PPP, which acts as an antagonist on postsynaptic and as an agonist on autoreceptor DA sites, reduced avoidance with no effect on escape behaviour (6.8-13.6 mg/kg). However, this reduction of CAR occurred at doses much higher than those previously demonstrated to inhibit locomotor activity. This profile is discussed in relation to the behavioural effects of classical postsynaptic DA receptor antagonists.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Clark D,Carlsson A,Hjorth S,Engel J,Lindberg Pdoi
10.1007/BF00439266subject
Has Abstractpub_date
1983-01-01 00:00:00pages
14-7issue
1eissn
0033-3158issn
1432-2072journal_volume
81pub_type
杂志文章abstract::The conditioned place preference technique was used to assess the affective properties of the direct dopamine D1 agonist, SKF38393, and the direct D2 agonist, LY171555 (quinpirole). A three compartment apparatus was used: the animals' pre-experimental preference for the two choice compartments was equal and, within ea...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244216
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:We have recently shown that post-extinction exposure of rats to a sub-threshold reminder shock can reactivate extinguished context-related freezing and found that chronic treatment with fluoxetine before fear extinction prevents this phenomenon. OBJECTIVES:In the present study, we examined whether these find...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2134-y
更新日期:2011-05-01 00:00:00
abstract:RATIONALE:Several recent studies have focused on glutamate modulating agents for symptoms relief in schizophrenia, especially negative symptoms which are resistant to conventional therapies. OBJECTIVES:We aimed to assess the efficacy and tolerability of riluzole, an anti-glutamate agent with neuroprotective properties...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3261-z
更新日期:2014-02-01 00:00:00
abstract::The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244001
更新日期:1990-01-01 00:00:00
abstract::In mice that were scored for the length of time they remained immobile in awkward postures (cataleptic) on an inclined wire grid, a large IP dose of pilocarpine (80 mg/kg) caused a clear catalepsy, which was prevented by both dopamine agonists that were tested, apomorphine (4 or 8 mg/kg, IP) and bromocriptine (8 mg/kg...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431769
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:New psychoactive substances (NPS) are chemical analogues designed to mimic the effects of various classic recreational drugs of abuse including MDMA, LSD, and cannabis. NPS use is associated with concern about the acute and longer-term effects particular substances might have, with abuse and addiction as pot...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-018-4931-7
更新日期:2018-08-01 00:00:00
abstract::The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442252
更新日期:1989-01-01 00:00:00
abstract::Recent studies suggest that glucose enhances memory in rodents and humans. The present experiment investigated the effects of glucose on memory performance and blood glucose changes in young adults (19-25 years). Subjects ingested (300 ml beverage) three doses of glucose (0, 30, 100 g) in a random, double-blind, tripl...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244373
更新日期:1991-01-01 00:00:00
abstract::The effects of scopolamine, an anticholinergic drug, of trimipramine, a tricyclic antidepressant with both anticholinergic and sedative properties, of diazepam and a placebo, on explicit memory and repetition priming were assessed using a free-recall task and a word-stem completion task. Forty-eight healthy volunteers...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244116
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:A glutamate-dopamine interaction has been implicated in the psychosis-like effects of glutamate N-methyl- D-aspartate (NMDA) receptor antagonists, such as phencyclidine and ketamine. However, recent imaging studies addressing striatal glutamate-dopamine interaction directly in vivo in man have been controvers...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1236-6
更新日期:2002-12-01 00:00:00
abstract::The relationship between changes in IV tyramine pressor sensitivity accompanying selective monoamine oxidase (MAO) inhibitor treatment and estimates of MAO-A and MAO-B inhibition in vivo were studied. Reductions in platelet MAO activity provided an index of MAO-B inhibition, while changes in plasma 3-methoxy-4-hydroxy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431748
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Major depression is a chronic disabling disorder, often preceded by stress. Despite emerging clinical interest in mechanisms perpetuating episodes of depression and/or establishing increased vulnerability for relapse, little attention has been paid to address these aspects in experimental models. Here, we stu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1835-6
更新日期:2010-06-01 00:00:00
abstract::The effect of ovarian steroids on the benzodiazepine receptor was assessed in the elevated plus-maze and, after restraint stress, in benzodiazepine receptor binding assays. Vehicle-treated proestrous rats displayed anxiolytic behavior, relative to diestrus or estrous rats. Anxiolytic behavior was observed after 1 or 2...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247394
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2942-3
更新日期:2013-05-01 00:00:00
abstract::Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02180028
更新日期:1988-01-01 00:00:00
abstract::The discriminative stimulus effect of midazolam, a short-acting benzodiazepine, was used for testing the effects of drugs thought to act as antagonists at different sites in the proposed benzodiazepine receptor complex. Rats were trained in a standard two-bar operant conditioning procedure with food reinforcers delive...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310626
更新日期:1986-01-01 00:00:00
abstract::The effect of aluminum on levels of inorganic phosphorus and acetylcholinesterase in blood and brain and on permeability of the blood-brain barrier (BBB) in different regions of the brain to the neuropeptide delta-sleep-inducing peptide (DSIP) was studied in adult rats. Aluminum (100 mg/kg) significantly increased the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431689
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1703-8
更新日期:2004-04-01 00:00:00
abstract:RATIONALE:N-methyl-D-aspartate (NMDA) receptor antagonists (e.g., PCP, ketamine) have been shown to impair learning/memory. Well documented in animal models, only limited research in humans has been reported. Findings to date are similar to results of animal studies; however, antagonists are typically administered befo...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-2179-5
更新日期:2005-07-01 00:00:00
abstract:RATIONALE:Despite the high prevalence of nicotine use in humans, robust nicotine self-administration has been difficult to demonstrate in laboratory animals. OBJECTIVES:A parametric analysis of nicotine self-administration was conducted to study its reinforcing effects in nonhuman primates. METHODS:Adult rhesus macaq...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4293-y
更新日期:2016-07-01 00:00:00
abstract:RATIONALE:Although some aspects of memory functions are known to be acutely impaired by delta(9)-tetrahydrocannabinol (delta(9)-THC; the main active constituent of marijuana), effects on other aspects of memory are not known and the time course of functional impairments is unclear. OBJECTIVE:The present study aimed to...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-002-1169-0
更新日期:2002-10-01 00:00:00
abstract:RATIONALE:Cannabinoid antagonists purportedly have greater effects in reducing the intake of highly palatable food compared to less palatable food. However, this assertion is based on free-feeding studies in which the amount of palatable food eaten under baseline conditions is often confounded with other variables, suc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3366-4
更新日期:2014-05-01 00:00:00
abstract::Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050730
更新日期:1998-10-01 00:00:00
abstract:RATIONALE:Obsessive-compulsive disorder (OCD) gradually emerges and reaches clinical significance during early adulthood. Whether a predisposition for OCD manifests as binge eating disorder earlier during adolescence is proposed. OBJECTIVES:To further characterize how OCD-like behaviors increase across maturation and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3967-1
更新日期:2015-09-01 00:00:00
abstract::Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435314
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:When paired with training, substances that increase monoaminergic transmission in the brain support motor and language learning in healthy subjects and in rehabilitation after brain lesions. OBJECTIVES:To test the hypotheses that enhancement of central norepinephrine by the selective norepinephrine reuptake ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0420-5
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Anti-psychotic treatment appears to be associated with striatal volume increase, but how early this change occurs is still unknown. METHODS:A single prospective cohort of 20 anti-psychotic-naïve patients, newly diagnosed with schizophrenia, underwent magnetic resonance imaging brain scan at baseline. This w...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1619-z
更新日期:2009-10-01 00:00:00
abstract:RATIONALE:Schizophrenia is a complex neuropsychiatric disorder characterized, in part, by impaired dopamine signaling. TAK-063 is a selective inhibitor of phosphodiesterase 10A, a key regulator of intracellular signaling pathways that is highly expressed in the striatum. OBJECTIVE:Safety, tolerability, and pharmacokin...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-016-4412-9
更新日期:2016-10-01 00:00:00
abstract::Murine neuroblastoma cells (clone N1E-115) possess both high- and low-affinity muscarinic receptors. The low-affinity muscarinic receptor, when stimulated, initiates the formation of cyclic GMP by activating the enzyme guanylate cyclase; whereas stimulation of the high-affinity receptor inhibits prostaglanding E1-medi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427901
更新日期:1985-01-01 00:00:00
abstract::The ability of delta 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8 alpha, 11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432273
更新日期:1979-03-28 00:00:00