Abstract:
:The relationship between changes in IV tyramine pressor sensitivity accompanying selective monoamine oxidase (MAO) inhibitor treatment and estimates of MAO-A and MAO-B inhibition in vivo were studied. Reductions in platelet MAO activity provided an index of MAO-B inhibition, while changes in plasma 3-methoxy-4-hydroxyphenethylene glycol (MHPG) were used as an hypothesized reflection of MAO-A inhibition. Chronic treatment with the MAO-A inhibitor clorgyline and the MAO-B inhibitor pargyline showed significant inhibition of the alternate MAO enzyme as well, although this crossover effect was greater for pargyline than clorgyline. The MAO-B inhibitor deprenyl appeared to maintain the greatest degree of MAO inhibition selectivity in vivo. Tyramine pressor sensitivity changes accompanying administration of the MAO inhibitors were highly correlated with decreases in plasma MHPG (r = 0.92), supporting our previous data indicating the rank order of clorgyline greater than pargyline greater than deprenyl for enhancement of tyramine pressor sensitivity and, thus, suggesting that tyramine potentiation is primarily a function of MAO-A rather than MAO-B inhibition. Changes in plasma MHPG are suggested to provide a potentially useful clinical index of in vivo MAO-A inhibition.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Pickar D,Cohen RM,Jimerson DC,Lake CR,Murphy DLdoi
10.1007/BF00431748subject
Has Abstractpub_date
1981-01-01 00:00:00pages
8-12issue
1eissn
0033-3158issn
1432-2072journal_volume
74pub_type
杂志文章abstract:AIM:The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF). METHOD:Following 2-4 h of nicotine abstinence, healthy chronic smokers participated in four sets of rCBF studies, H2(15)O positron emission tomography, during a simple sensory motor control...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1758-2
更新日期:2010-03-01 00:00:00
abstract::Three adult baboons were trained using a psychophysical procedure to discriminate between different synthetic vowel sounds [symbol: see text]. Baboons pressed and held a lever down to produce a pulsed train of a single reference vowel that served as the standard stimulus. Animals were trained to release the lever only...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246089
更新日期:1995-11-01 00:00:00
abstract::Development of tolerance to neuroleptic compounds tested in the conditional avoidance model was investigated. Since tolerance may manifest itself by a diminished potency and/or a shortened duration of effect, the complete time course of effect was registered in these experiments. Rats were pretreated approximately 2 w...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426314
更新日期:1976-12-21 00:00:00
abstract:RATIONALE:Major depression is a chronic disabling disorder, often preceded by stress. Despite emerging clinical interest in mechanisms perpetuating episodes of depression and/or establishing increased vulnerability for relapse, little attention has been paid to address these aspects in experimental models. Here, we stu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1835-6
更新日期:2010-06-01 00:00:00
abstract::Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-trea...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00470580
更新日期:1982-01-01 00:00:00
abstract::5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050711
更新日期:1998-10-01 00:00:00
abstract:RATIONALE:Recent findings have shown a complexly regulated 5-HT system as it is linked to different kinds of aggression. OBJECTIVE:We focus on (1) phasic and tonic changes of 5-HT and (2) state and trait of aggression, and emphasize the different receptor subtypes, their role in specific brain regions, feed-back regul...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-010-2000-y
更新日期:2011-02-01 00:00:00
abstract:AIM:It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin re...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4664-z
更新日期:2017-08-01 00:00:00
abstract::The capacity of the specific narcotic antagonists naltrexone and naloxone to block the discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete-trial avoidance task. The antagonists produced a dose-dependent and time-dependent blockade of morphine's effects as measured by resp...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00430479
更新日期:1976-11-10 00:00:00
abstract:RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2032-3
更新日期:2011-02-01 00:00:00
abstract:RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluate...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0274-2
更新日期:2006-03-01 00:00:00
abstract:RATIONALE/OBJECTIVES:Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS:Twe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0006-7
更新日期:2005-09-01 00:00:00
abstract:RATIONALE:Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05194-3
更新日期:2019-10-01 00:00:00
abstract::A recent study from our laboratory has demonstrated that C57BL/6 male mice that are chronically injected with nicotine develop a profound tolerance to nicotine that is not associated with changes in brain nicotinic receptors. We have proposed that alterations in the secretion of corticosterone (CCS) may regulate toler...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245877
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:The intake of psychostimulant drugs may induce cognitive dysfunction and negative affective-like states, and is associated with increased activity of stress-responsive systems. The corticotropin-releasing factor (CRF) system mediates neuroendocrine, behavioural and autonomic responses to stressors, and might ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3534-1
更新日期:2014-10-01 00:00:00
abstract:RATIONALE:Combining neuroleptics with 5-HT1A ligands is thought to improve the preclinical profile of neuroleptics and may be of interest in the development of new compounds that have greater therapeutic potential and/or are better tolerated. OBJECTIVE:To examine 1) the ability of 5-HT1A ligands to alter the effects o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050972
更新日期:1999-05-01 00:00:00
abstract:RATIONALE:The majority of pharmacotherapies proposed for cocaine dependence have been marginally effective and frequently have undesirable side effects. We recently demonstrated that short-term treatment with citicoline decreased self-reported desire to use cocaine in crack cocaine users. OBJECTIVE:The present study w...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130100824
更新日期:2001-09-01 00:00:00
abstract::Murine neuroblastoma cells (clone N1E-115) possess both high- and low-affinity muscarinic receptors. The low-affinity muscarinic receptor, when stimulated, initiates the formation of cyclic GMP by activating the enzyme guanylate cyclase; whereas stimulation of the high-affinity receptor inhibits prostaglanding E1-medi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427901
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Medication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of whi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3408-y
更新日期:2014-06-01 00:00:00
abstract:RATIONALE:Benzodiazepine agonists characteristically increase food intake in humans and non-human subjects, and the underlying mechanisms of this effect are not understood completely. OBJECTIVE:Compounds with selectivity for GABAA receptor subtypes were used to evaluate the role of GABAA receptors containing alpha1 an...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0431-2
更新日期:2006-08-01 00:00:00
abstract:RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-3423-z
更新日期:2014-09-01 00:00:00
abstract:RATIONALE:The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period cou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2960-1
更新日期:2013-05-01 00:00:00
abstract::The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244001
更新日期:1990-01-01 00:00:00
abstract::In order to study experimental alcohol intake that leads to heightened aggression, we established ethanol self-administration in aggressive rats. The focus was on low doses of self-administered ethanol and to assess their effects on aggressive behavior in resident rats, using a limited access paradigm followed by a 5-...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050295
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To evaluate prospectively interferon alpha (IFN-alpha) associated effects on cerebral glucose metabolism and its correlation to neuropsychiatric symptoms during low-dose IFN-alpha-treatment. METHODS:Eleven patients treated with low-dose IFN-alpha for chronic hepatitis C were prospectively evaluated by neurop...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130000549
更新日期:2000-11-01 00:00:00
abstract:RATIONALE:Pharmacokinetics of melatonin in children might differ from that in adults. OBJECTIVES:This study aims to establish a dose-response relationship for melatonin in advancing dim light melatonin onset (DLMO), sleep onset (SO), and reducing sleep onset latency (SOL) in children between 6 and 12 years with chroni...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-010-1962-0
更新日期:2010-10-01 00:00:00
abstract::The present study assessed the discriminative stimulus effects of the delta-opioid agonist [D-Pen2-D-Pen5]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between i.c.v injections of 100 micrograms [D-Pen2-D-Pen5]enkephalin (DPDPE) and saline in a two-key operant procedure; acquisiti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract:RATIONALE:Early life exposure to stress and to GABAA receptor modulators have well-defined and persistent behavioral effects. A single neonatal injection of the GABAergic neurosteroid allopregnanolone (3alpha-hydroxy,5alpha-pregnane-20-one, 10 mg/kg, i.p.) alters the localization of prefrontal cortex (PFC) interneurons...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0360-0
更新日期:2006-06-01 00:00:00
abstract::After initial exposure to 80 mg/kg, pigeons trained on a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40-160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of responses directed to the ethosuximide-appropriate ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00207236
更新日期:1987-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The mechanisms underlying relapse to cocaine seeking induced by exposure to priming cocaine injections, cues associated with cocaine self-administration and environmental stressors have been studied in rats. Here we describe a reinstatement method for studying relapse to cocaine seeking in mice...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1047-9
更新日期:2002-06-01 00:00:00