Abstract:
RATIONALE:Medication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of which psychometric tests are best suited for initial screening of a drug's driving impairment potential. OBJECTIVE:The aim of this alcohol calibration study is to determine which performance tests are useful to measure drug-induced impairment. The effects of alcohol are used to compare the psychometric quality between tests and as benchmark to quantify performance changes in each test associated with potentially impairing drug effects. METHODS:Twenty-four healthy volunteers participated in a double-blind, four-way crossover study. Treatments were placebo and three different doses of alcohol leading to blood alcohol concentrations (BACs) of 0.2, 0.5, and 0.8 g/L. RESULTS:Main effects of alcohol were found in most tests. Compared with placebo, performance in the Divided Attention Test (DAT) was significantly impaired after all alcohol doses and performance in the Psychomotor Vigilance Test (PVT) and the Balance Test was impaired with a BAC of 0.5 and 0.8 g/L. The largest effect sizes were found on postural balance with eyes open and mean reaction time in the divided attention and the psychomotor vigilance test. CONCLUSIONS:The preferable tests for initial screening are the DAT and the PVT, as these tests were most sensitive to the impairing effects of alcohol and being considerably valid in assessing potential driving impairment.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Jongen S,Vuurman E,Ramaekers J,Vermeeren Adoi
10.1007/s00213-013-3408-ysubject
Has Abstractpub_date
2014-06-01 00:00:00pages
2435-47issue
12eissn
0033-3158issn
1432-2072journal_volume
231pub_type
杂志文章abstract::In a series of experiments, rats received the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK-801 and measures were made of motor behavior, spatial navigation in a swimming pool, and electroencephalographic (EEG) activity. High doses (0.25-10 mg/kg IV) produced somnolence and akinesia, impaired food consumpti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00441949
更新日期:1989-01-01 00:00:00
abstract::The cataleptogenic effect of delta 9-THC was compared to its discriminative stimulus effects in rats. The ED50s for the discriminative stimulus and catalepsy were 0.8 and 4.0 mg/kg, respectively, while their time courses were very similar. The ED50 of delta 9-THC for catalepsy in experimentally naive rats was not diff...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244975
更新日期:1992-01-01 00:00:00
abstract::We examined whether any locus postsynaptic to the GABAergic striatonigral projection might be involved in the enhancement of behavioral response to dopaminergic stimulants induced by chronic treatment with either neuroleptic drugs or stimulants. Rats exposed chronically to either chlorpromazine or cocaine were tested ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212767
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in adolescents remain controversial with respect to later development of cocaine abuse. Past research demonstrated that adolescent methylphenidate treatment increased several aspects of cocaine self-administration during adulthood using...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4419-2
更新日期:2016-12-01 00:00:00
abstract:RATIONALE:It is important to study age-related differences that may put adolescents at risk for alcohol-related problems. Adolescents seem less sensitive to the aversive effects of ethanol than adults. Less is known of appetitive effects of ethanol and stress modulation of these effects. OBJECTIVES:This study aims to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3163-0
更新日期:2013-12-01 00:00:00
abstract:RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3940-z
更新日期:2015-08-01 00:00:00
abstract::Chronic oral administration of cannabis extract to rats (daily delta 9-tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radial-arm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treated for either 6...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431932
更新日期:1982-01-01 00:00:00
abstract::Benzodiazepines and other compounds which act at benzodiazepine binding sites have been shown previously to attenuate the acquisition of conditioned fear in rodents when administered before the acquisition session, an effect which may parallel the disruption of human memory produced by anxiolytics and sedatives. Such ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181243
更新日期:1986-01-01 00:00:00
abstract::Sixteen healthy volunteers were administered midazolam followed by placebo or the benzodiazepine antagonist, flumazenil, in a double-blind, cross-over study. Flumazenil reversed midazolam-induced sedation on the subjective, psychophysiological and motor indices used. In contrast, there was little evidence of any rever...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244252
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Multiple low doses of cocaine (COC) may cause intermittent vasoconstriction and reperfusion, leading to elevations in damaging reactive oxygen species, such as hydroxyl free radicals (*OH). Salicylate may offer protection because it reacts with *OH and/or because of its anti-inflammatory actions. OBJECTIVE:T...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100726
更新日期:2001-06-01 00:00:00
abstract::The effects of diazepam (10 mg orally) on the responding of normal human volunteers was studied in a procedure that involved the maintenance of operant behavior by monetary reinforcement and its suppression by monetary loss (punishment). Diazepam produced an antipunishment effect as shown by an increase in behavior su...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00426457
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Schizophrenia is a complex neuropsychiatric disorder characterized, in part, by impaired dopamine signaling. TAK-063 is a selective inhibitor of phosphodiesterase 10A, a key regulator of intracellular signaling pathways that is highly expressed in the striatum. OBJECTIVE:Safety, tolerability, and pharmacokin...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-016-4412-9
更新日期:2016-10-01 00:00:00
abstract::The glutamatergic cortico-striatal and subthalamo-entopeduncular pathways are both overactive in parkinsonism. Previous behavioural investigations have shown that intra-entopeduncular injection of either NMDA-site or glycine-site antagonists results in alleviation of parkinsonian symptoms, although injection of the fo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246054
更新日期:1995-05-01 00:00:00
abstract::Methaqualone produces a dose- and time-dependent increase in plasma corticosterone concentration in mice. Acute studies showed that this effect is largely independent of methaqualone-induced hypothermia but can be blocked by pretreatment with dexamethasone, thus demonstrating that the adrenal cortex is not being direc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426541
更新日期:1977-08-31 00:00:00
abstract:RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1187-y
更新日期:2002-11-01 00:00:00
abstract::Animals responding for biphasic square wave stimulation to the VTA were treated for 26 days with a low dose (0.07 mg/kg) of the neuroleptic haloperidol and tested at 1 h post-injection. Initially the drug induced a pronounced lateral displacement of the baseline rate-intensity function, concomitant with a depression i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245756
更新日期:1990-01-01 00:00:00
abstract::The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml i.v.) or received yok...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050496
更新日期:1998-01-01 00:00:00
abstract::Roxindole is a potent autoreceptor-selective dopamine agonist with additional properties as a serotonin reuptake inhibitor and 5-HT1A agonist. In order to get more insight into its mode of action in various psychiatric populations, we evaluated the effects of subchronic roxindole treatment on pituitary and adrenal hor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246221
更新日期:1995-02-01 00:00:00
abstract::Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-003-1567-y
更新日期:2004-01-01 00:00:00
abstract::The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244300
更新日期:1991-01-01 00:00:00
abstract::Efforts to find a correlation between serum levels of chlorpromazine (CPZ) and clinical effect have been rather unsuccessful, which could be due to fluctuations of CPZ and CPZ metabolite levels during treatment, the complicated metabolism of CPZ, or to varying degrees of protein binding. Using a mass fragmentographic ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00431102
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:The role of pharmacotherapy in the treatment of major depressive disorder (MDD) in youth has received much attention in recent years due to concerns of efficacy and safety of the antidepressants for the treatment of MDD in youth. OBJECTIVES:This review describes the existing published and unpublished literat...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0442-z
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Rivastigmine patches are used for patients with Alzheimer's disease (AD), but little is known about the serum concentration of rivastigmine and its metabolite or clinical adherence in relation to skinfold thickness after rivastigmine patch application. OBJECTIVES:The aim of this study was to examine the asso...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5135-x
更新日期:2019-04-01 00:00:00
abstract::The aim of the present study was to evaluate the effects of nicotinic acetylcholine receptor (nACh-R) agonists such as (-)-nicotine and related compounds on brain monoamine turnover. A single administration of (-)-nicotine (0.04, 0.2, 1.0, and 5.0 mg/kg SC) increased both noradrenaline (NA) and dopamine (DA) turnover ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050184
更新日期:1997-02-01 00:00:00
abstract::We investigated the possibility that repeated electrical stimulation of the basolateral amygdala (kindling) would increase punished behavior, a pre-clinical indicator of anti-anxiety activity. Male Sprague-Dawley rats, prepared with electrodes in the left basolateral nucleus and frontal cortex, were trained to bar-pre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00216053
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Temporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Studies using the fixed-interval peak procedure implicated D2 dopamine receptors in these effects. Less is known about the effects of dopaminergic manipulations on temporal differentiation in other timing schedules. OBJ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0339-x
更新日期:2006-04-01 00:00:00
abstract::The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02251292
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been eq...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4834-7
更新日期:2018-04-01 00:00:00
abstract::Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s002130050320
更新日期:1997-07-01 00:00:00
abstract:RATIONALE:Despite animal evidence that methylenedioxymethamphetamine (ecstasy) causes lasting damage in brain regions related to long-term memory, results regarding human memory performance have been variable. This variability may reflect the cognitive complexity of the memory tasks. However, previous studies have test...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1766-2
更新日期:2010-03-01 00:00:00