Abstract:
:We examined whether any locus postsynaptic to the GABAergic striatonigral projection might be involved in the enhancement of behavioral response to dopaminergic stimulants induced by chronic treatment with either neuroleptic drugs or stimulants. Rats exposed chronically to either chlorpromazine or cocaine were tested for behavioral responses to bilateral intranigral microinfusions of muscimol (2.5 ng bilaterally). Chronic chlorpromazine-treated rats responded with more intense stereotypy to nigral muscimol than controls, but chronic cocaine-treated rats were less responsive than controls to intranigral muscimol. It therefore appears that changes in the responsiveness of neural outputs from, or distal to, substantia nigra may contribute to the enhanced behavioral effects of dopaminergic stimulants caused by chronic exposure to dopaminergic antagonists, but that the critical neural changes responsible for cocaine sensitization probably do not occur at, or distal to, the nigral outflow from the basal ganglia. At least at the nigral level, different neural mechanisms evidently mediate the increased stereotypy response to dopaminergic stimulation induced by chronic administration of either neuroleptic or stimulant drugs.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Bachus SE,Gale Kdoi
10.1007/BF00212767subject
Has Abstractpub_date
1988-01-01 00:00:00pages
56-62issue
1eissn
0033-3158issn
1432-2072journal_volume
95pub_type
杂志文章abstract::Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245309
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435276
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Gabolysat PC60 is a fish protein hydrolysate with anxiolytic properties commonly used as a nutritional supplement. OBJECTIVE:The diazepam-like effects of PC60 on stress responsiveness of the rat pituitary-adrenal system and on sympathoadrenal activity were studied. METHODS:The activity of the pituitary-adre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002139900338
更新日期:2000-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3285-4
更新日期:2014-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00436164
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIV...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4913-9
更新日期:2018-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3261-z
更新日期:2014-02-01 00:00:00
abstract::Recent clinical data suggest that buspirone may enhance the efficacy and/or reduce the latency to therapeutic effect of selective serotonin reuptake inhibitors (SSRIs) in unipolar major depressive disorder. The present study, using the mouse forced swimming test, was performed to investigate further the mechanisms inv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050663
更新日期:1998-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1371-0
更新日期:2003-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00187245
更新日期:1987-01-01 00:00:00
abstract::Under the fixed-consecutive-number schedule (FCN), pigeons were reinforced for responding eight or more times on one response key (work key), and then responding once on a second response key. In one component of this schedule, an external stimulus signalled the completion of the response requirement on the work key (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174698
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically. OBJECTIVES:The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) r...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2376-3
更新日期:2011-11-01 00:00:00
abstract::The purpose of this study was to assess the effects of acute nicotine administration, following a 12-h cigarette deprivation period, using a computerized performance assessment battery (PAB). The PAB was comprised of five tasks which were selected to reflect a variety of complex acquired behaviors, sometimes referred ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00443406
更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00177563
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2501-3
更新日期:2012-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244103
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Demonstrations of associative tolerance to the analgesic effects of morphine, not confounded by practice or novelty effects, have been restricted to the tail-flick and flinch-jump tests. OBJECTIVES:Experiment 1 investigated whether associative tolerance would be found on two other nociceptive assessment meth...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051077
更新日期:1999-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00212837
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Clozapine is a unique antipsychotic with very low propensity to cause motor side effects. In contrast to most other antipsychotics that block more than 70% of dopamine D(2) receptors at therapeutic doses, clozapine occupies less than 70%. Furthermore, even at maximum occupancy, 70% is not exceeded. Several me...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-001-0967-0
更新日期:2002-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174684
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00176837
更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1554-3
更新日期:2003-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02245003
更新日期:1993-01-01 00:00:00
abstract::Administration of drugs that reduce the influence of dopamine at its receptor site can lead to postsynaptic supersensitivity, whereas treatment with dopamine (DA) agonists can cause postsynaptic subsensitivity. Both unaltered and enhanced postsynaptic responses to DA have been shown after pretreatment with DA agonists...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428198
更新日期:1985-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5107-1
更新日期:2019-02-01 00:00:00
abstract:RATIONALE:Intermittent footshock stress reliably reinstates extinguished alcohol-taking behavior in drug-free rats, but the neurochemical events involved in this effect are not known. OBJECTIVE:We studied here whether two main modulators of stress responses, corticotropin-releasing factor (CRF) and corticosterone, are...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000411
更新日期:2000-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02245438
更新日期:1994-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00496071
更新日期:1979-08-08 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02249415
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:Acute diazepam administration has been shown to decrease plasma cortisol levels consistent with decreased activity of the hypothalamic-pituitary-adrenal axis, especially in individuals experiencing stress. However, the effects of chronic diazepam treatment on cortisol have been less studied, and the relations...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-004-1974-8
更新日期:2005-02-01 00:00:00