Limited stimulus generalization between delta 9-THC and diazepam in pigeons and gerbils.

Abstract:

:Pigeons trained to discriminate between the presence and absence of delta 9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6-30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. Two groups of gerbils trained to discriminate between the presence and absence of IP (intraperitoneally) injected benzodiazepine agonists (5.6 mg/kg of diazepam and Ro 11-3128, respectively) generally did not generalize the drug response to IP administered THC (5.6 and 17.5 mg/kg). In addition, substitution testing with the dopamine autoreceptor blocker (+)-3PPP yielded non-drug responding in the pigeons. Hence neither proposed structural similarity between 3-PPP and THC, nor purported anxiolytic activity by 3-PPP (see Introduction) matched the THC-induced stimulus effects. The data are discussed with reference to the specificity of the THC cue or stimulus.

journal_title

Psychopharmacology

authors

Järbe TU,Hiltunen AJ

doi

10.1007/BF00174684

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

328-31

issue

3

eissn

0033-3158

issn

1432-2072

journal_volume

94

pub_type

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