Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task.

abstract：:The number of nerve cells in two different areas of the corpus striatum (i.e., ventrolateral and dorsomedial) was estimated in rat brain after long-term (36 weeks) treatment with the neuroleptic flupenthixol. Nine rats were given weekly injections of 4 mg/kg flupenthixol dissolved in Viscoleo i.m., and seven rats rece...

journal_title：Psychopharmacology

authors： Nielsen EB,Lyon M

更新日期：1978-09-15 00:00:00

abstract：:During the third week of life, a hyperactive period for laboratory rat, the occurrence of 8 behavioral categories was recorded in individual littermates transferred to a novel environment. Neonatal destruction of the catecholaminergic system by intraventricular injection of 6-OH-DA resulted in increased motor activity...

journal_title：Psychopharmacology

authors： Stoof JC,Duijkstra H,Hillegers JP

更新日期：1978-04-28 00:00:00

abstract：:The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...

journal_title：Psychopharmacology

authors： Sørensen B,Kragh-Sørensen P,Larsen NE,Hvidberg EF

更新日期：1978-09-15 00:00:00

abstract：:It has been suggested that reward-related learning may require intact functioning at the dopamine D1 receptor. The present experiment tested this hypothesis by challenging the reward-enhancing effects of the D2 agonist, bromocriptine, with a D1 antagonist, SCH 23390. For comparison, the effects of the D2 antagonist, p...

journal_title：Psychopharmacology

authors： Ranaldi R,Beninger RJ

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:Many of the biochemical, physiological, and behavioral effects of ethanol are known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates metabotropic glutamate receptors (mGluRs) in the biobehavioral effects of ethanol and other drugs of abuse, but there is little information regardi...

journal_title：Psychopharmacology

authors： Hodge CW,Miles MF,Sharko AC,Stevenson RA,Hillmann JR,Lepoutre V,Besheer J,Schroeder JP

更新日期：2006-01-01 00:00:00

abstract：:Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and ha...

journal_title：Psychopharmacology

authors： Jerussi TP,Glick SD

更新日期：1976-06-23 00:00:00

abstract：RATIONALE:We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. OBJECTIVES:The aim of this study was to evaluate the effect of Valeriana officinalis root extract on preventio...

journal_title：Psychopharmacology

authors： Hassani S,Alipour A,Darvishi Khezri H,Firouzian A,Emami Zeydi A,Gholipour Baradari A,Ghafari R,Habibi WA,Tahmasebi H,Alipour F,Ebrahim Zadeh P

更新日期：2015-03-01 00:00:00

abstract：RATIONALE:Phytocannabinoids are useful therapeutics for multiple applications including treatments of constipation, malaria, rheumatism, alleviation of intraocular pressure, emesis, anxiety and some neurological and neurodegenerative disorders. Consistent with these medicinal properties, extracted cannabinoids have rec...

journal_title：Psychopharmacology

authors： Deiana S,Watanabe A,Yamasaki Y,Amada N,Arthur M,Fleming S,Woodcock H,Dorward P,Pigliacampo B,Close S,Platt B,Riedel G

更新日期：2012-02-01 00:00:00

abstract：:This study demonstrates that pre-exposure to stress influences subsequent effects of stress on pain sensitivity (stress-induced analgesia) and on plasma corticosterone and brain catecholamine activity. Animals exposed to a 30 min shock session (S1 = 8, 5.0 s shocks) 10 days earlier showed a significant attenuation of ...

journal_title：Psychopharmacology

authors： Caggiula AR,Antelman SM,Aul E,Knopf S,Edwards DJ

更新日期：1989-01-01 00:00:00

abstract：:The serotonin 5-HT(3) receptor is thought to play a role in the reward pathway and drug abuse by modulating dopamine release within the mesolimbic pathway. Dopamine release stimulated by cocaine and methamphetamine is blocked by administration of 5-HT(3) receptor antagonists. Animal studies demonstrate that 5-HT(3) re...

journal_title：Psychopharmacology

authors： Allan AM,Galindo R,Chynoweth J,Engel SR,Savage DD

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:Although most opioid self-administration research has been conducted with laboratory animals, such research with humans is necessary to answer questions unique to human drug-taking behavior. OBJECTIVE:We investigated the influence of morphine dose and an alternative non-drug reinforcer on choice between morp...

journal_title：Psychopharmacology

authors： Heishman SJ,Schuh KJ,Schuster CR,Henningfield JE,Goldberg SR

更新日期：2000-02-01 00:00:00

abstract：:To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) af...

journal_title：Psychopharmacology

authors： Bhatara V,Arnold LE,Knopp W,Smeltzer DJ

更新日期：1978-04-28 00:00:00

abstract：RATIONALE:Multiple low doses of cocaine (COC) may cause intermittent vasoconstriction and reperfusion, leading to elevations in damaging reactive oxygen species, such as hydroxyl free radicals (*OH). Salicylate may offer protection because it reacts with *OH and/or because of its anti-inflammatory actions. OBJECTIVE:T...

journal_title：Psychopharmacology

authors： Castelli MC,Venturini L,Sparber SB

更新日期：2001-06-01 00:00:00

abstract：:In order to assess the contribution of cerebellar effects of ethanol to the production of ataxia, "nervous" (nr/nr) and control (nr/+ or +/+) C3H mice were tested for locomotor ability 2 min after being given intraperitoneal ethanol injections. The nr/nr mice suffer from loss of most of their cerebellar Purkinje cells...

journal_title：Psychopharmacology

authors： Northup LR

更新日期：1976-07-28 00:00:00

abstract：:It has been suggested that anxiety may be a critical factor in certain forms of non-opioid environmental analgesia. In the present study, 5-min exposure to the elevated plus-maze test of anxiety (EPM) induced a mild, though enduring, elevation in tail-flick latencies in male mice. Pretreatment with the opiate antagoni...

journal_title：Psychopharmacology

authors： Lee C,Rodgers RJ

更新日期：1990-01-01 00:00:00

abstract：:It has been proposed that serotonin (5-HT) antagonists counteract neuroleptic-induced extrapyramidal symptoms by disinhibition of dopamine activity. The effects of the 5-HT antagonist mianserin, the anticholinergic drug procyclidine and placebo were evaluated in 16 psychiatric patients with chronic neuroleptic-induced...

journal_title：Psychopharmacology

authors： Korsgaard S,Friis T

更新日期：1986-01-01 00:00:00

abstract：:To analyze the involvement of dopamine (DA) and serotonin (5-HT) release in the stimulus properties of methamphetamine, two amphetamine analogs that selectively release either brain DA (phentermine) or 5-HT (fenfluramine) were tested for their ability to substitute for methamphetamine in rats discriminating methamphet...

journal_title：Psychopharmacology

authors： Munzar P,Baumann MH,Shoaib M,Goldberg SR

更新日期：1999-01-01 00:00:00

abstract：:The effects of benztropine, scopolamine, atropine, methylatropine, amitriptyline, phencyclidine, and meperidine were determined alone and in conjunction with a behaviorally suppressing dose (0.05 mg/kg IM) of oxotremorine in pigeons responding under a multiple fixed-ratio 30 fixed-interval 5-min schedule of grain pres...

journal_title：Psychopharmacology

authors： Leander JD

更新日期：1981-01-01 00:00:00

abstract：:Two principal oblique factors are identified in the Bass Social Acquiescence Scale, a measure previously shown to correlate positively with placebo response and negatively with anxiolytic drug response. The two factors appeared very similar in separate analyses of data from samples of 941 psychiatric outpatients and 1...

journal_title：Psychopharmacology

authors： McNair DM,Barrett JE

更新日期：1979-10-01 00:00:00

abstract：RATIONALE:A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents. OBJECTIVE:Our primary goal was to examine the putati...

journal_title：Psychopharmacology

authors： Calcagnoli F,de Boer SF,Althaus M,den Boer JA,Koolhaas JM

更新日期：2013-10-01 00:00:00

abstract：RATIONALE:Brain reward pathways implicated in addiction appear to be less reactive in regular drug users; behavioural manifestations may include decreased sensitivity to natural reinforcers. OBJECTIVES:This study aimed to replicate earlier findings of abstinence-associated incentive motivation deficits in smokers and ...

journal_title：Psychopharmacology

authors： Dawkins L,Powell JH,West R,Powell J,Pickering A

更新日期：2006-12-01 00:00:00

abstract：RATIONALE:The emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological symptoms has prompted the research on the consequences of acute and chronic use of these new psychoactive substances. Most studies on cannabinoid dependence have been per...

journal_title：Psychopharmacology

authors： Serrano A,Vadas E,Ferrer B,Bilbao A,Granado N,Suárez J,Pavon FJ,Moratalla R,Rodríguez de Fonseca F

更新日期：2021-02-01 00:00:00

abstract：RATIONALE:Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic-pituitary-adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, compounds that block the effects of stress hormones were investigated as potential therapeu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Wood SK,Houshyar H,Hsin LW,Rice KC,Woods JH

更新日期：2005-07-01 00:00:00

abstract：RATIONALE:The progesterone metabolite 5alpha-pregnane-3alpha-ol-20-one (3alpha,5alpha-THP) is an important modulator of the hypothalamic-pituitary-adrenal axis and stress-induced corticosterone response. Typically, 3alpha,5alpha-THP levels are increased in response to acute stress, which may then reduce corticosterone ...

journal_title：Psychopharmacology

authors： Frye CA,Rhodes ME,Raol YH,Brooks-Kayal AR

更新日期：2006-06-01 00:00:00

abstract：:Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...

journal_title：Psychopharmacology

authors： Stanhope KJ,Roe S,Dawson G,Draper F,Jackson A

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Hypersignaling of corticotropin releasing factor (CRF) has been implicated in stress disorders; however, many of its downstream mechanisms of action remain unclear. In vitro, CRF1 receptor activation initiates multiple cell signaling cascades, including protein kinase A (PKA), protein kinase C (PKC), and mito...

journal_title：Psychopharmacology

authors： Toth M,Gresack JE,Hauger RL,Halberstadt AL,Risbrough VB

更新日期：2013-10-01 00:00:00

abstract：:Acute alcohol intoxication disrupts memory acquisition in humans and laboratory animals. This review summarizes recent behavioral and immediate early gene expression studies addressing the mechanisms of this phenomenon. Most behavioral investigations agree that the amnestic effect of alcohol is due to its preferential...

journal_title：Psychopharmacology

authors： Ryabinin AE

更新日期：1998-09-01 00:00:00

abstract：:Ro 15-4513, a partial inverse agonist at the benzodiazepine (BZ) receptor site was labelled with 11C and used for in vitro autoradiography on human post mortem brain sections and for positron emission tomography (PET) on Cynomolgus monkeys. The total radiochemical yield of [11C]Ro 15-4513 was 30-40% with an overall sy...

journal_title：Psychopharmacology

authors： Halldin C,Farde L,Litton JE,Hall H,Sedvall G

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...

journal_title：Psychopharmacology

authors： Kalinichev M,Rourke C,Daniels AJ,Grizzle MK,Britt CS,Ignar DM,Jones DN

更新日期：2005-10-01 00:00:00

abstract：RATIONALE:Current medications for attention-deficit/hyperactivity disorder (ADHD) include some single isomer compounds [dextroamphetamine (D: -amphetamine, dexedrine) and dexmethylphenidate (Focalin)] and some racemic compounds [methylphenidate and mixed-salts amphetamine (Adderall)]. Adderall, which contains approxima...

journal_title：Psychopharmacology

authors： Glaser PE,Thomas TC,Joyce BM,Castellanos FX,Gerhardt GA

更新日期：2005-03-01 00:00:00