Bromocriptine enhancement of responding for conditioned reward depends on intact D1 receptor function.

abstract：RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...

journal_title：Psychopharmacology

authors： Harvey AJ,Bayless SJ,Hyams G

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:The indirect dopamine agonist methylphenidate remediates cognitive deficits in psychopathology, but the individual characteristics that determine its effects on the brain are not known. OBJECTIVES:We aimed to determine whether targeted dopaminergically modulated traits and individual differences could predic...

journal_title：Psychopharmacology

authors： Moeller SJ,Konova AB,Tomasi D,Parvaz MA,Goldstein RZ

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Recent research highlights the need to extend our understanding of how exercise may aid smoking cessation, through exploration of different modes, intensity and duration of exercise. OBJECTIVES:The purpose of the study was to examine the effects of a 1-mile self-paced walk on different measures of urges to s...

journal_title：Psychopharmacology

authors： Taylor AH,Katomeri M,Ussher M

更新日期：2005-08-01 00:00:00

abstract：RATIONALE:Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the ...

journal_title：Psychopharmacology

authors： Gomez J,Haas NA,Schwarz JM

更新日期：2019-10-01 00:00:00

abstract：:Two enantiomers (1S and 1R) of delta-3-tetrahydrocannabinol were assayed in man for psychoactivity. The 1S enantiomer had definite psychic actions, qualitatively similar to those of delta-1-tetrahydrocannabinol, but quantitatively less potent (1:3 to 1:6). Adding the two enantiomers together did not increase the effec...

journal_title：Psychopharmacology

authors： Hollister LE,Gillespie HK,Mechoulam R,Srebnik M

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Little is known about patterns of opiate use by heroin addicts. OBJECTIVES:To describe opiate use over time among heroin addicts who had access to legally prescribed intravenous heroin and oral opiates. METHODS:Analysis of daily drug administration records of 37 patients enrolled in the Geneva heroin mainte...

journal_title：Psychopharmacology

authors： Perneger TV,Mino A,Giner F,Broers B

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:The gut microbiota is increasingly recognized as a potential mediator of psychiatric diseases. Depressed patients have been shown to have a different microbiota composition compared with healthy controls, and several lines of research now aim to restore this dysbiosis. To develop novel treatments, preclinical...

journal_title：Psychopharmacology

authors： Tillmann S,Abildgaard A,Winther G,Wegener G

更新日期：2019-05-01 00:00:00

abstract：RATIONALE:Salvinorin A is the active component of the hallucinogenic plant Salvia divinorum. The potential mode of action of this hallucinogen was unknown until recently. A recent in vitro study detected high affinity and efficacy of salvinorin A at kappa-opioid receptors. It was postulated that salvinorin A would prod...

journal_title：Psychopharmacology

authors： Butelman ER,Harris TJ,Kreek MJ

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:Observing responses bring sensory receptors into contact with environmental stimuli. In the observing-response procedure, periods in which an operant response (e.g. pressing a lever) is reinforced by drug deliveries alternate with periods in which this response is never reinforced (i.e. extinction). These alt...

journal_title：Psychopharmacology

authors： Shahan TA

更新日期：2003-05-01 00:00:00

abstract：:In rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle, pretreatment with the D1 DA antagonists, SCH 23390 (7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1H-3-benzazepin e) and A66359 (1- 2-bromo-4,5-dimethoxybenzyl]-7-hydroxy-6-methoxy-2-methyl- 1,2,3,4 tetrahydroisoquinol...

journal_title：Psychopharmacology

authors： Gnanalingham KK,Hunter AJ,Jenner P,Marsden CD

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:Dependence on both alcohol and cocaine is a widespread example of polydrug abuse/dependence. It has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. However, little is known about the neurobiology of ethanol in p...

journal_title：Psychopharmacology

authors： Bradberry CW

更新日期：2002-12-01 00:00:00

abstract：RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...

journal_title：Psychopharmacology

authors： Jensen KP,Valentine G,Gueorguieva R,Sofuoglu M

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:Ecstasy is a commonly used psychoactive drug with 3,4-methylenedioxymethamphetamine (MDMA) as the main content. Importantly, it has been suggested that use of MDMA may be neurotoxic particularly for serotonergic (5-hydroxytryptamine (5-HT)) neurons. In the past decades, several molecular imaging studies exami...

journal_title：Psychopharmacology

authors： Vegting Y,Reneman L,Booij J

更新日期：2016-10-01 00:00:00

abstract：:The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally stimulated b...

journal_title：Psychopharmacology

authors： Acquas E,Fibiger HC

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Drug development is a high-risk and high failure enterprise, and studies that provide an early read on the pharmacodynamic activity of novel compounds could save time and money, increasing the efficiency of the drug development process. OBJECTIVE:Preclinical and clinical experiments were designed to examine ...

journal_title：Psychopharmacology

authors： Lenz RA,Baker JD,Locke C,Rueter LE,Mohler EG,Wesnes K,Abi-Saab W,Saltarelli MD

更新日期：2012-03-01 00:00:00

abstract：RATIONALE:Humans typically self-administer cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) together repeatedly (as in cannabis, cannabis extract, or Sativex®) to relieve pain. It has been suggested that one benefit of the drug combination may be decreased tolerance development. OBJECTIVE:The present study com...

journal_title：Psychopharmacology

authors： Greene NZ,Wiley JL,Yu Z,Clowers BH,Craft RM

更新日期：2018-11-01 00:00:00

abstract：:the immediate posttrial injection of oxotremorine (0.250 mu Mol/kg, IP) can facilitate the retention of a passive-avoidance response in mice. After the administration of alfa-methyl-p-tyrosine methylester (alpha-MPT) by intracerebroventricular injection at doses that had no effect on retention (100 microgram, 10 micro...

journal_title：Psychopharmacology

authors： Huygens P,Baratti CM,Gardella JL,Filinger E

更新日期：1980-01-01 00:00:00

abstract：:The low rate of success for identifying effective treatments for cognitive dysfunction has prompted recent efforts to improve pharmaceutical discovery and development. In particular, investigators have emphasized improving translation from pre-clinical to clinical research. A specific area of focus has been touchscree...

journal_title：Psychopharmacology

authors： Mohler EG,Ding Z,Rueter LE,Chapin D,Young D,Kozak R

更新日期：2015-11-01 00:00:00

abstract：:Three-hour sessions of differential reinforcement of low-rate behavior (DRL 45-s) in rats were used to investigate alprazolam, caffeine, and their interactions at the onset, peak and disappearance of serum alprazolam, while caffeine level remained constant. The dose-response curve (DRC) method of Pöch permitted an ext...

journal_title：Psychopharmacology

authors： Lau CE,Wang J

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:It has been suggested that the antipsychotic effect of antipsychotics is mediated by the antagonism of the dopamine D2 receptor in the limbic-cortical regions. Risperidone has an atypical property, but its effect on limbic-cortical regions has not been evaluated. OBJECTIVES:In this study, we examined the rel...

journal_title：Psychopharmacology

authors： Yasuno F,Suhara T,Okubo Y,Sudo Y,Inoue M,Ichimiya T,Tanada S

更新日期：2001-02-01 00:00:00

abstract：RATIONALE:The exact behavioral nature of drug-induced reinstatement of drug seeking is still debated. As an incentive, the drug can have general facilitatory influences on appetitive behaviors. As an interoceptive stimulus, the drug can acquire discriminative properties and control behavior. OBJECTIVE:This study asses...

journal_title：Psychopharmacology

authors： Keiflin R,Isingrini E,Cador M

更新日期：2008-05-01 00:00:00

abstract：RATIONALE:Recent studies have shown that pharmacological inhibition of the 12-lipoxygenase pathway selectively blocks opioid inhibition of GABAergic synaptic currents. A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, al...

journal_title：Psychopharmacology

authors： Walters CL,Wang BC,Godfrey M,Sun D,Funk CD,Blendy JA

更新日期：2003-11-01 00:00:00

abstract：:Quetiapine (Seroquel, ICI 204,636) is an atypical antipsychotic that is effective in the treatment of both positive and negative symptoms of schizophrenia, and has a low propensity to cause extrapyramidal symptoms. The compound has a relatively short plasma elimination half-life (approximately 7 h). However, since dop...

journal_title：Psychopharmacology

authors： King DJ,Link CG,Kowalcyk B

更新日期：1998-05-01 00:00:00

abstract：:Pigeons were trained to acquire a new 4-response sequence in each session by pecking three keys in a predetermined order. The key color varied for each step under the chained schedule, but there was only one key color under the tandem schedule. Under the reset contingency, incorrect responses produced a reset of the 4...

journal_title：Psychopharmacology

authors： Harting J,Mcmillian DE

更新日期：1976-09-29 00:00:00

abstract：:Rats that are placed in a novel environment containing a probe will explore the environment and the probe. Exploration of the probe is reduced when the probe is electrified. We here report that chlordiazepoxide blocks this inhibition, and have determined some of the pharmacological features of this new experimental pr...

journal_title：Psychopharmacology

authors： Meert TF,Colpaert FC

更新日期：1986-01-01 00:00:00

abstract：INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...

journal_title：Psychopharmacology

authors： Robinson OJ,Sahakian BJ

更新日期：2009-08-01 00:00:00

abstract：:Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...

journal_title：Psychopharmacology

authors： Heinsbroek RP,van Haaren F,Zantvoord F,van de Poll NE

更新日期：1987-01-01 00:00:00

abstract：:Postsynaptic dopamine-cholecystokinin (CCK) interactions in the nucleus accumbens were studied in two behavioral preparations of DA receptor supersensitivity: chronic-neuroleptic treated and 6-hydroxydopamine (6-OHDA) denervated rats. Subcutaneous (SC) injections of apomorphine (APO; 0.15 mg/kg) in experiment 1 produc...

journal_title：Psychopharmacology

authors： Weiss F,Ettenberg A,Koob GF

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Impulsive behavior is associated with both alcohol use disorders and a family history of alcoholism (FHA). One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement. OBJECTIVE:Employ functional magnetic resonance imaging (f...

journal_title：Psychopharmacology

authors： Kareken DA,Dzemidzic M,Wetherill L,Eiler W 2nd,Oberlin BG,Harezlak J,Wang Y,O'Connor SJ

更新日期：2013-07-01 00:00:00

abstract：RATIONALE:Demonstrations of associative tolerance to the analgesic effects of morphine, not confounded by practice or novelty effects, have been restricted to the tail-flick and flinch-jump tests. OBJECTIVES:Experiment 1 investigated whether associative tolerance would be found on two other nociceptive assessment meth...

journal_title：Psychopharmacology

authors： Cepeda-Benito A,Tiffany ST,Cox LS

更新日期：1999-08-01 00:00:00