Abstract:
:Rats that are placed in a novel environment containing a probe will explore the environment and the probe. Exploration of the probe is reduced when the probe is electrified. We here report that chlordiazepoxide blocks this inhibition, and have determined some of the pharmacological features of this new experimental procedure. The procedure appears to be sensitive to the effects of several benzodiazepines, barbiturates, and related compounds. Limited activity was observed with most 5-HT antagonists, ritanserin, an anticholinergic, a beta-adrenergic blocker and a neuroleptic. Of the antidepressants, only imipramine had some limited activity. Inactive compounds in this procedure include benzodiazepine antagonists, buspirone, convulsants, opiates, an opiate antagonist, stimulants, a putative DA agonist and antagonist, histamine antagonists, a cholinomimetic, anticholinergics, a NE antagonist, alpha 2 agonists, an alpha 2 antagonist, MAO inhibitors, 5-HTP and LSD.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Meert TF,Colpaert FCdoi
10.1007/BF00178505subject
Has Abstractpub_date
1986-01-01 00:00:00pages
445-50issue
4eissn
0033-3158issn
1432-2072journal_volume
88pub_type
杂志文章abstract:RATIONALE:Adolescence marks a period of increased vulnerability to the development of substance use disorders. High sweet preference is a genetically mediated behavioral trait that also predicts vulnerability to substances of abuse. Previous research has shown that while adolescent rats selectively bred for high (HiS) ...
journal_title:Psychopharmacology
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更新日期:2013-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1999-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050563
更新日期:1998-04-01 00:00:00
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1979-01-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-05-01 00:00:00
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更新日期:1994-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2000-09-01 00:00:00
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更新日期:2010-07-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:1999-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00177913
更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00