Abstract:
RATIONALE:A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. OBJECTIVE:To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI, rather than simple sex differences in the regulation of PPI. A retrospective analyses of >600 carefully screened normals tested over the past 12 years was completed. RESULTS:Male>female acoustic PPI was detected in analyses that included: 1) all subjects; or 2) self-declared non-smokers. CONCLUSIONS:Sex differences in PPI cannot be accounted for by smoking history, because they are present across a large sample of non-smoking normal controls.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Swerdlow NR,Geyer MA,Hartman PL,Sprock J,Auerbach PP,Cadenhead K,Perry W,Braff DLdoi
10.1007/s002130051111subject
Has Abstractpub_date
1999-09-01 00:00:00pages
228-32issue
2eissn
0033-3158issn
1432-2072pii
91460228.213journal_volume
146pub_type
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