Abstract:
:Intraperitoneal (IP) administration of the acetylcholinesterase inhibitor, soman (10-40 micrograms/kg), suppressed in a dose-related manner response rates in rats maintained under a multiple fixed-interval 50-s fixed-ratio 25 schedule of food delivery. Chronic administration of soman at weekly intervals resulted in tolerance to the response. When soman administration was separated by 2-5 weeks in individual rats, the suppressive effects of the agent again became apparent. Analysis of acetylcholinesterase activity revealed that enzyme inhibition was limited to gastrointestinal areas near the site of injection. There was no significant effect on brain acetylcholinesterase even following IP injection of doses which completely suppressed responding. The IP route may be useful for studying tolerance and other chronic effects of soman without producing generalized toxicity.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Hymowitz N,Brezenoff HE,McGee J,Campbell K,Knight Vdoi
10.1007/BF00427899subject
Has Abstractpub_date
1985-01-01 00:00:00pages
404-8issue
4eissn
0033-3158issn
1432-2072journal_volume
86pub_type
杂志文章abstract:RATIONAL:In recent years, evidence suggests that modafinil may be useful for certain symptom domains of schizophrenia, especially for the negative and cognitive symptoms. However, the results are not consistent. OBJECTIVE:This study was designed to investigate the effect of modafinil added to risperidone in patients w...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2513-z
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0111-7
更新日期:2006-06-01 00:00:00
abstract::5,7-Dihydroxytryptamine (5,7-DHT) or the vehicle was administered once into both lateral ventricles of the rat. Desmethylimipramine (DMI) was administered IP prior to the intraventricular injection of 5,7-DHT to prevent the destruction of norepinephrine (NE) terminals. Following recovery from surgery, ethanol (5 g/kg,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431969
更新日期:1980-02-01 00:00:00
abstract::Systemic administration of RB 101, a complete inhibitor of the enkephalin degrading enzymes, has been reported to induce naltrindole-reversed antidepressant-like effects in the conditioned suppression of motility (CSM) test in mice. The selective CCKB antagonist L-365,260 also elicits the same naltrindole-blocked resp...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245811
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVES:Early onset of heroin use during adolescence might increase chances of later drug addiction. Prior work from our laboratory suggests, however, that adolescent male rats are actually less sensitive than adults to some enduring effects of heroin self-administration. In the present study, we tested two likely c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2847-1
更新日期:2013-02-01 00:00:00
abstract::The effects of amphetamine on the partial punishment effect (PPE) at one trial per day, were examined. Two groups of animals were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially punished (PP) group received food reward on every trial but in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310526
更新日期:1986-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244976
更新日期:1992-01-01 00:00:00
abstract::The aim of the present study was to (i) characterise the mouse behavioural profile (particularly social interactions) during the preweaning period, (ii) assess the effects of prenatal exposure to an anticonvulsant drug widely used in clinical practice, (iii) examine possible genetic differences both in baseline behavi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245214
更新日期:1994-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1134-y
更新日期:2002-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445554
更新日期:1989-01-01 00:00:00
abstract::In a series of experiments, rats received the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK-801 and measures were made of motor behavior, spatial navigation in a swimming pool, and electroencephalographic (EEG) activity. High doses (0.25-10 mg/kg IV) produced somnolence and akinesia, impaired food consumpti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00441949
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including patients with neuropsychiatric disorders. OBJECTIVES:This brief review exemplifies this appro...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-019-05302-3
更新日期:2019-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050481
更新日期:1998-01-01 00:00:00
abstract::Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439445
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The thalamus is a major target of dopaminergic projections and is densely connected with the prefrontal cortex. A better understanding of how dopamine changes thalamo-cortical communication may shed light on how dopamine supports cognitive function. Methylphenidate has been shown to facilitate cognitive proc...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-020-05505-z
更新日期:2020-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050438
更新日期:1997-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000602
更新日期:2000-12-01 00:00:00
abstract:RATIONALE:Environmental context has been shown to influence responding under multiple schedules of food reinforcement and to modify the behavioral effects of drugs. However, no systematic study has been conducted under conditions of cocaine self-administration. The hypothesis was that changes in the magnitude of food r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1202-3
更新日期:2002-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2456-4
更新日期:2012-03-01 00:00:00
abstract::Central dopaminergic transmission has been implicated in memory processes. The present experiments examined the effects of several direct acting dopaminergic agents on performance of a delayed-non-match-to-sample radial arm maze task. Preadministration of apomorphine (D1-D2 agonist; 0.25, 0.5, and 1.0 mg/kg), quinpiro...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245288
更新日期:1992-01-01 00:00:00
abstract::The aim of the present study was to evaluate the effects of cholinergic receptor blockade in the rat prefrontal cortex on cognitive processes. The nicotinic antagonists neuronal bungarotoxin and dihydro-beta-erythroidine and the muscarinic antagonist scopolamine were injected into the prelimbic area of the prefrontal ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246154
更新日期:1995-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245135
更新日期:1992-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Footshock stress reliably reinstates heroin seeking in rats, but the time course of the development of this effect following drug withdrawal is not known. Here we studied the effect of intermittent footshock stress on reinstatement of heroin seeking following different withdrawal periods (1-66 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100748
更新日期:2001-06-01 00:00:00
abstract:RATIONALE:The occurrence of methamphetamine (METH) use by the smoking route is increasing. A nonhuman primate model for examining the reinforcing effects of smoked METH would be valuable for testing potential interventions for treating METH abuse disorders. OBJECTIVE:The purpose of the present study was to examine the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0479-z
更新日期:2006-10-01 00:00:00
abstract::The antipsychotic drugs haloperidol and clozapine have the common action of increasing dopamine metabolism in the striatum (nucleus accumbens, caudate-putamen) of the rat. Intracerebroventricular administration of kainic acid (KA) produces neuronal loss in limbic-cortical brain regions which project directly or indire...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050384
更新日期:1997-09-01 00:00:00
abstract::Although previous studies have shown that pharmacological agents, such as buprenorphine, and alternative nondrug reinforcers, such as money or sweetened solutions, reduce cocaine self-administration, few studies have examined the combined effects of these two approaches. The purpose of the present study was to evaluat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246018
更新日期:1996-06-01 00:00:00
abstract::Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4906-8
更新日期:2018-07-01 00:00:00
abstract::Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02180028
更新日期:1988-01-01 00:00:00
abstract::The mesolimbic dopamine (DA) system has been implicated in conditioned reward (CR), locomotor sensitization, and the reinforcing properties of psychomotor stimulants. Stimuli with formerly motivationally neutral properties that gain incentive properties by their predictive association with primary reinforcers are term...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050859
更新日期:1999-02-01 00:00:00
abstract::There were marked strain differences in the duration of the protective effects of diazepam against the convulsant actions of penylenetetrazole and picrotoxin in mice. In no case was significant protection found at 12 h or longer, regardless of whether the incidence of or the latencies to myoclonus or tonic-clonic conv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431698
更新日期:1985-01-01 00:00:00