Abstract：
RATIONALE:Preclinical studies suggest that medications enhancing the brain gamma amino butyric acid (GABA) system attenuate the rewarding effects of stimulants including nicotine. These preclinical studies have not been followed up in systematic human studies. OBJECTIVES:This study was conducted to examine the effects of a GABAergic medication, tiagabine, on acute physiological and subjective effects of intravenous (i.v.) nicotine and on tobacco withdrawal symptoms in overnight abstinent smokers. The proposed mechanism of action for tiagabine is selective inhibition of GABA transporter type I, which leads to increases in synaptic GABA levels. METHODS:Eight male and four female smokers participated in a double-blind, placebo-controlled, crossover study. In each of three experimental sessions, participants were treated orally with a single 4- or 8-mg dose of tiagabine or placebo. Two hours following the medication treatment, participants received i.v. saline, followed 30 min later by 1.5 mg/70 kg i.v. nicotine. RESULTS:Tiagabine treatment did not affect the heart rate or blood pressure changes induced by nicotine. There was a significant treatment effect for the subjective responses to nicotine, such that tiagabine, compared to placebo, attenuated the ratings of "good effects" and "drug liking." Tiagabine treatment at 8 mg attenuated the craving for cigarettes and enhanced the cognitive performance in the Classical Stoop Tests, compared to placebo or 4 mg tiagabine condition. CONCLUSIONS:These results suggest that GABA enhancing medication tiagabine may reduce the rewarding effects of nicotine and improve cognitive performance in abstinent smokers. The utility of GABA medications for smoking cessation needs to be examined further in controlled clinical trials.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Sofuoglu M,Mouratidis M,Yoo S,Culligan K,Kosten Tdoi
10.1007/s00213-005-0010-ysubject
Has Abstractpub_date
2005-09-01 00:00:00pages
504-10issue
3eissn
0033-3158issn
1432-2072journal_volume
181pub_type
杂志文章,随机对照试验abstract：:The discriminative stimulus effect of midazolam, a short-acting benzodiazepine, was used for testing the effects of drugs thought to act as antagonists at different sites in the proposed benzodiazepine receptor complex. Rats were trained in a standard two-bar operant conditioning procedure with food reinforcers delive...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00310626
更新日期：1986-01-01 00:00:00
abstract：:Tardive dyskinesia has been hypothesized to be caused by a neuroleptic-induced dopamine hypersensitivity in the nigrostriatal system. This study evaluated with dopamine antagonists the possibility that such dopamine hypersensitivity extends to the tuberoinfundibular dopamine (TIDA) system, which regulates, by inhibiti...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428314
更新日期：1979-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Previous studies show that electrical stimulation of the ventral subiculum (vSub) can reinstate drug-seeking behavior in rats following extinction. This study examined whether vSub stimulation could also evoke reinitiation of d-amphetamine (d-AMPH) self-administration during voluntary abstinenc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1337-2
更新日期：2003-07-01 00:00:00
abstract：:It has been suggested that the GAbAergic striatonigral projection may form part of the efferent pathway responsible for the expression of dopamine-related oral behaviour. Consistent with this suggestion are reports that bilateral injection of the GABA agonist muscimol can produce stereotyped gnawing and biting. We rep...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00464579
更新日期：1982-01-01 00:00:00
abstract：:It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244064
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000572
更新日期：2001-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247372
更新日期：1993-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245615
更新日期：1996-03-01 00:00:00
abstract：RATIONALE:Previous studies indicate that the rewarding effect of D-1 dopamine receptor stimulation in nucleus accumbens (NAc) shell is greater in food-restricted (FR) than in ad libitum fed (AL) rats. The D-1 receptor is positively coupled to adenylyl cyclase and activates protein kinase A (PKA). OBJECTIVES:The purpos...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2602-z
更新日期：2012-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433814
更新日期：1980-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427569
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. OBJECTIVE:The present study sought to characterize the effects of several dopamine D(4) agonists and antagonists on the disc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1238-0
更新日期：2009-04-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050249
更新日期：1997-04-01 00:00:00
abstract：RATIONALE:We have recently shown that post-extinction exposure of rats to a sub-threshold reminder shock can reactivate extinguished context-related freezing and found that chronic treatment with fluoxetine before fear extinction prevents this phenomenon. OBJECTIVES:In the present study, we examined whether these find...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-2134-y
更新日期：2011-05-01 00:00:00
abstract：:The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in an...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00427969
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Abnormalities of cortical evoked potentials and background electroencephalographic (EEG) frequencies occur in several psychiatric disorders, some of which, especially depression, are associated with hypercortisolaemia. However, there have been few investigations of the effects of exogenously administered cort...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130000528
更新日期：2000-09-01 00:00:00
abstract：RATIONALE:3-(4-Fluorophenylselenyl)-2,5-diphenylselenophene (F-DPS) is a promising organoselenium compound that shows antidepressant-like properties related to interaction with the serotonergic system. OBJECTIVES:In this study, a mouse model of anxiety/depressant-like behavior induced by long-term corticosterone treat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3361-9
更新日期：2014-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246641
更新日期：1996-02-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00735875
更新日期：1988-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00215492
更新日期：1987-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02180039
更新日期：1988-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1998-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244411
更新日期：1990-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1994-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426726
更新日期：1979-03-22 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427650
更新日期：1980-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2005-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0301-3
更新日期：2006-04-01 00:00:00
abstract：:Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. We used the endocrine and hypothermic responses to the 5-HT1A receptor agonist, gepirone (20 mg orally), to ass...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050348
更新日期：1997-08-01 00:00:00
