Abstract:
:Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. We used the endocrine and hypothermic responses to the 5-HT1A receptor agonist, gepirone (20 mg orally), to assess 5-HT1A receptor sensitivity in 37 healthy male volunteers who were studied before and following random double-blind, allocation to treatment with paroxetine, nefazodone or placebo for 17 days. Following antidepressant drug treatment, hypothermic responses to gepirone were markedly decreased by paroxetine but only slightly diminished by nefazodone. Paroxetine also lowered the growth hormone and cortisol responses to gepirone. There was no change in either hypothermic or endocrine response following placebo treatment. Our results suggest that paroxetine treatment produces a striking attenuation of measures of both pre- and post-synaptic 5-HT1A receptor function. Nefazodone appears to decrease the sensitivity of 5-HT1A autoreceptors to some extent and this effect may contribute to its antidepressant activity.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Sargent P,Williamson DJ,Pearson G,Odontiadis J,Cowen PJdoi
10.1007/s002130050348subject
Has Abstractpub_date
1997-08-01 00:00:00pages
296-302issue
3eissn
0033-3158issn
1432-2072journal_volume
132pub_type
临床试验,杂志文章,随机对照试验abstract:RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2734-9
更新日期:2012-11-01 00:00:00
abstract:RATIONALE:Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. OBJECTIVES:Here, we decided to investigate the possible role of the group III mGlu receptor ligands, LSP1-2111, the g...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2502-2
更新日期:2012-04-01 00:00:00
abstract::The effects of alcohol on locomotor activity of group- and individually-housed mice were studied using direct ethological observations, including a detailed postural analysis and measures of both locomotion and immobility. Ethanol (0, 0.5, 1.0 and 2.0 g/kg, IP) was given to subjects placed alone in a novel cage, and v...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464793
更新日期:1984-01-01 00:00:00
abstract::Pretreatment of rats with hydantoin (75 mg/kg, PO, an anticonvulsant), trihexyphenidyl (10 mg/kg, SC, a muscarinic cholinergic antagonist), or piperonyl butoxide (500 mg/kg, PO, a metabolic inhibitor) had no effect on the whole blood or brain tissue levels of orally administered DDT (75 mg/kg) or its metabolites DDD a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174359
更新日期:1986-01-01 00:00:00
abstract::Low doses of 8-OH-DPAT (62.5-250 micrograms/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244082
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:The aim of our study was to test whether ketamine produces an antidepressant effect in animal model of olfactory bulbectomy and assess the role of mammalian target of rapamycin (mTOR) pathway in ketamine's antidepressant effect. METHODS:Bulbectomized (OBX) rats and sham controls were assigned to four subgrou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4256-3
更新日期:2016-06-01 00:00:00
abstract:RATIONALE:An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia. OBJECTIVES:The objective of this study is to determine the effect of intrav...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3684-1
更新日期:2015-02-01 00:00:00
abstract:RATIONALE:Pavlovian conditioning with a discrete reward-predictive visual cue can elicit two classes of behaviors: "sign-tracking" (approach toward and contact with the cue) and "goal-tracking" (approach toward the site of reward delivery). Sign-tracking has been proposed to be linked to behavioral disorders involving ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1353-y
更新日期:2009-03-01 00:00:00
abstract:RATIONALE:Previous work has shown that clozapine suppressed tacrine-induced jaw movements at lower doses than those required for suppression of lever pressing. OBJECTIVE:The novel atypical antipsychotic olanzapine was assessed in these behavioral tests. METHODS:The effect of acute olanzapine on the suppression of tac...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051063
更新日期:1999-08-01 00:00:00
abstract::Rats exhibit profound individual differences in their propensity to ingest sugar and in their locomotor response to AMP. Intrinsic variation in the responsiveness of mesolimbic dopamine mechanisms has been suggested to account for these individual differences. In light of this overlap, it might be expected that indivi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244864
更新日期:1994-09-01 00:00:00
abstract::In an attempt to define the nature of the involvement of delta 9-tetrahydrocannabinol (THC) with central cholinergic neurotransmission, the effects of THC on direct cholinergic stimulation of the rat brain were investigated. THC, in doses of 3 mg/kg and 6 mg/kg, administered intraperitoneally (i.p.), potentiated the e...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426661
更新日期:1979-02-28 00:00:00
abstract::The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 microgram...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00470593
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Prepulse inhibition (PPI) of the startle response in mice is increasingly used as a paradigm of sensory gating with potential predictive and construct validity towards schizophrenia. OBJECTIVES:Establishment of a mouse PPI paradigm in which typical and atypical antipsychotic drugs directly improve a low perf...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100828
更新日期:2001-07-01 00:00:00
abstract::BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431632
更新日期:1977-03-16 00:00:00
abstract::The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a much less effective...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426965
更新日期:1978-04-14 00:00:00
abstract:RATIONALE:Buprenorphine reduces both heroin and cocaine intake in opioid addicts, but the mechanisms remain unclear. OBJECTIVES:To determine the effects of chronic buprenorphine treatment on intake of heroin and/or cocaine and measure nucleus accumbens (NAc) dopamine (DA) levels during self-administration. METHODS:In...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0485-1
更新日期:2006-09-01 00:00:00
abstract::Food reward has been associated with activation of noradrenergic mechanisms in the brain. Using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food rew...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427343
更新日期:1979-06-28 00:00:00
abstract:RATIONALE:The noradrenergic and dopaminergic systems are targets for antidepressants and are stimulated by serotonergic antidepressant drugs. The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidep...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1381-7
更新日期:2009-03-01 00:00:00
abstract:RATIONALE:The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. OBJECTIVES:The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat. METHODS:In Experimen...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4184-7
更新日期:2016-03-01 00:00:00
abstract::Changes in saccadic eye movements before and after up to 10 mg oral diazepam were measured electrooculographically in diazepam-naive humans. Diazepam produced dose-dependent increases in saccade duration and decreases in maximum saccade velocity over a 2--36 degrees range of saccade amplitudes. The magnitude of drug-i...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427100
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:A growing number of studies suggest that gamma-aminobutyric acid type-B (GABA(B)) receptor agonists reduce alcohol use and craving. OBJECTIVES:This study was designed to further clarify behavioral mechanism(s) by which GABA(B) agonists may decrease alcohol reinforcement. METHODS:Male C57BL/6 J mice were tra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1769-3
更新日期:2004-07-01 00:00:00
abstract:RATIONALE:3-(4-Fluorophenylselenyl)-2,5-diphenylselenophene (F-DPS) is a promising organoselenium compound that shows antidepressant-like properties related to interaction with the serotonergic system. OBJECTIVES:In this study, a mouse model of anxiety/depressant-like behavior induced by long-term corticosterone treat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3361-9
更新日期:2014-05-01 00:00:00
abstract:RATIONALE:Mice are useful tools for dissecting genetic and environmental factors in relation to the study of attention and impulsivity. The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented. OBJECTIVES:This study aims to s...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-011-2560-5
更新日期:2012-01-01 00:00:00
abstract::Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02245204
更新日期:1994-01-01 00:00:00
abstract::Pigeons trained to discriminate between the presence and absence of delta 9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6-30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174684
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Salvinorin A is the active component of the hallucinogenic plant Salvia divinorum. The potential mode of action of this hallucinogen was unknown until recently. A recent in vitro study detected high affinity and efficacy of salvinorin A at kappa-opioid receptors. It was postulated that salvinorin A would prod...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1638-0
更新日期:2004-03-01 00:00:00
abstract:RATIONALE:Behavioral and dopamine responses to cocaine are sexually dimorphic: Female rats exhibit higher levels of locomotor and reward-associated behaviors after cocaine administration and dopamine release than do males. Activation of the dopamine- and cAMP-regulated phosphoprotein of Mr 32 kDa (DARPP-32) intracellul...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1388-0
更新日期:2009-03-01 00:00:00
abstract::The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426469
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:We previously demonstrated that the addition of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain. Using the same study sample, we also sought to determine whether reboxetine's weight-attenuating effect was accompanied by a beneficial effect on metabolic and ...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3199-1
更新日期:2013-11-01 00:00:00
abstract:RATIONALE:Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3'-Cl-BZT and 4'-Cl-B...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000616
更新日期:2001-04-01 00:00:00