Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone.


:The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a much less effective inhibitor of strychnine convulsion. Methaqualone elicits muscle-relaxant, sedative, and anticonvulsant effects at different dose levels. At low, nonsedative doses the drug produces anticonvulsant effects, and at higher doses, muscle-relaxant and sedative effects. It appears that the mechanism(s) of action of methaqualone in on GABA deficiency or receptor blockade, rather than on glycine receptors.




Naik SR,Naid PR,Sheth UK




Has Abstract


1978-04-14 00:00:00












  • Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.

    abstract:RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...


    pub_type: 杂志文章


    authors: Sukhtankar DD,Lee H,Rice KC,Ko MC

    更新日期:2014-04-01 00:00:00

  • Ketamine reduces temporal expectation in the rhesus monkey.

    abstract:RATIONALE:Ketamine, a well-known general dissociative anesthetic agent that is a non-competitive antagonist of the N-methyl-D-aspartate receptor, perturbs the perception of elapsed time and the expectation of upcoming events. OBJECTIVE:The objective of this study was to determine the influence of ketamine on temporal ...


    pub_type: 杂志文章


    authors: Brulé S,Herlin B,Pouget P,Missal M

    更新日期:2021-02-01 00:00:00

  • Age difference in apomorphine-induced stereotypy in rats: relationship to plasma and brain concentrations.

    abstract::Relationships between aging effects on apomorphine (AP)-induced stereotypy and AP concentrations in plasma and brain were studied in rats. In two separate behavioral studies, four groups of male Wistar rats (3, 6, 20, and 43 weeks of age) and two groups of female Wistar rats (5 and 35 weeks of age) were used, respecti...


    pub_type: 杂志文章


    authors: Watanabe H,Nakano S,Ogawa N

    更新日期:1982-01-01 00:00:00

  • A mouse model of early social interactions after prenatal drug exposure: a genetic investigation.

    abstract::The aim of the present study was to (i) characterise the mouse behavioural profile (particularly social interactions) during the preweaning period, (ii) assess the effects of prenatal exposure to an anticonvulsant drug widely used in clinical practice, (iii) examine possible genetic differences both in baseline behavi...


    pub_type: 杂志文章


    authors: Laviola G,Terranova ML,Sedowofia K,Clayton R,Manning A

    更新日期:1994-01-01 00:00:00

  • Tremorous mouth movements in rats administered chronic neuroleptics.

    abstract::Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the upper and low lips using TV images. The human observer data indicated that during HAL administration the total dur...


    pub_type: 杂志文章


    authors: Ellison G,See R,Levin E,Kinney J

    更新日期:1987-01-01 00:00:00

  • Effects of three therapeutic doses of codeine/paracetamol on driving performance, a psychomotor vigilance test, and subjective feelings.

    abstract:RATIONALE:Some recent pharmacoepidemiological studies revealed an elevated risk of driving accidents after opioid analgesics uses. Among analgesics, codeine is often associated with paracetamol in numerous pharmaceutical specialties. OBJECTIVES:The objective of this study was to evaluate the dose-effect relationship o...


    pub_type: 杂志文章,随机对照试验


    authors: Amato JN,Marie S,Lelong-Boulouard V,Paillet-Loilier M,Berthelon C,Coquerel A,Denise P,Bocca ML

    更新日期:2013-07-01 00:00:00

  • The catechol-O-methyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting.

    abstract:RATIONALE:The noradrenergic and dopaminergic systems are targets for antidepressants and are stimulated by serotonergic antidepressant drugs. The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidep...


    pub_type: 杂志文章


    authors: Benedetti F,Colombo C,Pirovano A,Marino E,Smeraldi E

    更新日期:2009-03-01 00:00:00

  • Dopamine and conditioned reinforcement. I. Differential effects of amphetamine microinjections into striatal subregions.

    abstract::In the conditioned reinforcement paradigm, animals learn a new instrumental response reinforced solely by conditioned reward (a stimulus that has previously been associated with primary reward). It has been shown that psychostimulants potentiate responding for conditioned reward and there is evidence that the nucleus ...


    pub_type: 杂志文章


    authors: Kelley AE,Delfs JM

    更新日期:1991-01-01 00:00:00

  • Modulation of 5-HT7 receptor: effect on object recognition performances in mice.

    abstract:OBJECTIVE:Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryp...


    pub_type: 杂志文章


    authors: Freret T,Paizanis E,Beaudet G,Gusmao-Montaigne A,Nee G,Dauphin F,Bouet V,Boulouard M

    更新日期:2014-01-01 00:00:00

  • Analysis of licking microstructure provides no evidence for a reduction in reward value following acute or sub-chronic phencyclidine administration.

    abstract:RATIONALE:The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards. OBJECTIVES:Experiment 1 investigated whet...


    pub_type: 杂志文章


    authors: Lydall ES,Gilmour G,Dwyer DM

    更新日期:2010-04-01 00:00:00

  • Development of tolerance to the antinociceptive effect of metergoline.

    abstract::Metergoline given IP reduced the response to noxious stimulation in the mouse formalin test. Tolerance to this effect developed after a chronic treatment schedule consisting of ten daily injections of 5 mg/kg. Twenty four hours after the last injection a test dose of metergoline (2.5 mg/kg) reduced the licking time in...


    pub_type: 杂志文章


    authors: Fasmer OB,Berge OG,Hole K

    更新日期:1987-01-01 00:00:00

  • Chronic neuroleptic effects on spatial reversal learning in monkeys.

    abstract::Cebus apella monkeys were chronically administered the antipsychotic drug fluphenazine decanoate for periods ranging from 3.5 to 5.5 years. In the present study, four of these monkeys and two controls were tested for cognitive abilities on a spatial learning task, which consisted of an original discrimination and four...


    pub_type: 杂志文章


    authors: Levin ED,Gunne LM

    更新日期:1989-01-01 00:00:00

  • Purine nucleoside--mediated immobility in mice: reversal by antidepressants.

    abstract::In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucle...


    pub_type: 杂志文章


    authors: Kulkarni SK,Mehta AK

    更新日期:1985-01-01 00:00:00

  • Kappa opioids and the modulation of pain.

    abstract:BACKGROUND AND RATIONALE:Pain is a complex sensory experience, involving cognitive factors, environment (setting, society, and culture), experience, and gender and is modulated significantly by the central nervous system (CNS). The mechanisms by which opioid analgesics work are understood, but this class of drugs is no...


    pub_type: 杂志文章,评审


    authors: Kivell B,Prisinzano TE

    更新日期:2010-06-01 00:00:00

  • Comparison between the effects of propranolol and chlordiazepoxide on timing behaviour in the rat.

    abstract::Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...


    pub_type: 杂志文章


    authors: Salmon P,Gray JA

    更新日期:1985-01-01 00:00:00

  • Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT₁A receptor agonists F15599 and F13714 in male WTG rats.

    abstract:BACKGROUND:The serotonin (5-HT) deficiency hypothesis of aggression is being seriously challenged by pharmacological data showing robust anti-aggressive effects of 5-HT1A receptor agonists in dose ranges that concomitantly inhibit 5-HT neurotransmission. Hence, an adequate interpretation of the role of 5-HT activity in...


    pub_type: 杂志文章


    authors: de Boer SF,Newman-Tancredi A

    更新日期:2016-03-01 00:00:00

  • Alprazolam, caffeine and their interaction: relating DRL performance to pharmacokinetics.

    abstract::Three-hour sessions of differential reinforcement of low-rate behavior (DRL 45-s) in rats were used to investigate alprazolam, caffeine, and their interactions at the onset, peak and disappearance of serum alprazolam, while caffeine level remained constant. The dose-response curve (DRC) method of Pöch permitted an ext...


    pub_type: 杂志文章


    authors: Lau CE,Wang J

    更新日期:1996-07-01 00:00:00

  • A double-blind placebo controlled experimental study of nicotine: I--effects on incentive motivation.

    abstract:RATIONALE:Brain reward pathways implicated in addiction appear to be less reactive in regular drug users; behavioural manifestations may include decreased sensitivity to natural reinforcers. OBJECTIVES:This study aimed to replicate earlier findings of abstinence-associated incentive motivation deficits in smokers and ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dawkins L,Powell JH,West R,Powell J,Pickering A

    更新日期:2006-12-01 00:00:00

  • Aspects of amitriptyline and nortriptyline plasma levels monitoring in depression.

    abstract::Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...


    pub_type: 杂志文章


    authors: Corona GL,Cucchi ML,Frattini P,Santagostino G,Schinelli S,Zerbi F,Savoldi F

    更新日期:1990-01-01 00:00:00

  • Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs.

    abstract::Prepulse inhibition (PPI) of an acoustic startle response is impaired in schizophrenics. PPI can also be studied in the rat, and is impaired by dopamine (DA) D2/3 receptor agonists such as apomorphine. This disruption is reversed by DA antagonists, leading to proposals that this approach may be a useful means to ident...


    pub_type: 杂志文章


    authors: Varty GB,Higgins GA

    更新日期:1995-11-01 00:00:00

  • Abolition of latent inhibition by a single 5 mg dose of d-amphetamine in man.

    abstract::The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of d-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of d-amphetamine would disrupt LI. The prediction was supported with lef...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gray NS,Pickering AD,Hemsley DR,Dawling S,Gray JA

    更新日期:1992-01-01 00:00:00

  • Comparison of the pharmacologic effects of N-allylnormetazocine and phencyclidine: sensitization, cross-sensitization, and opioid antagonist activity.

    abstract::The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling...


    pub_type: 杂志文章


    authors: Iwamoto ET

    更新日期:1986-01-01 00:00:00

  • Synergistic interaction between baclofen administration into the median raphe nucleus and inconsequential visual stimuli on investigatory behavior of rats.

    abstract:RATIONALE:Noncontingent administration of amphetamine into the ventral striatum or systemic nicotine increases responses rewarded by inconsequential visual stimuli. When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABA(B) receptor agonis...


    pub_type: 杂志文章


    authors: Vollrath-Smith FR,Shin R,Ikemoto S

    更新日期:2012-03-01 00:00:00

  • Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist.

    abstract:RATIONALE:Environmental context has been shown to influence responding under multiple schedules of food reinforcement and to modify the behavioral effects of drugs. However, no systematic study has been conducted under conditions of cocaine self-administration. The hypothesis was that changes in the magnitude of food r...


    pub_type: 杂志文章


    authors: Nader MA,Sinnott RS,Mach RH,Morgan D

    更新日期:2002-10-01 00:00:00

  • Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats.

    abstract::Fluctuations in extracellular dopamine and DOPAC levels in nucleus accumbens septi (NAS) were monitored in 1-min microdialysis samples taken from rats engaged in intravenous cocaine self-administration. For four rats the dose per injection was fixed at 2.0 mg/kg; for four others the dose per injection was varied irreg...


    pub_type: 杂志文章


    authors: Wise RA,Newton P,Leeb K,Burnette B,Pocock D,Justice JB Jr

    更新日期:1995-07-01 00:00:00

  • Nicotine-induced enhancements in the five-choice serial reaction time task in rats are strain-dependent.

    abstract:RATIONALE:Clinically, nicotine improves attention, but this has proven difficult to demonstrate preclinically. We tested nicotine in Sprague-Dawley (SD) and Lister hooded (LH) rats in the five-choice serial reaction time task. Since SD rats demonstrate lower asymptotic performance than LH rats, we surmised that nicotin...


    pub_type: 杂志文章


    authors: Mirza NR,Bright JL

    更新日期:2001-02-01 00:00:00

  • Naltrexone reduces the relative reinforcing value of nicotine in a cigarette smoking choice paradigm.

    abstract:RATIONALE:Human behavioral pharmacology studies can examine how medications that target different neurotransmitter systems influence different aspects of smoking. Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have...


    pub_type: 临床试验,杂志文章


    authors: Rukstalis M,Jepson C,Strasser A,Lynch KG,Perkins K,Patterson F,Lerman C

    更新日期:2005-06-01 00:00:00

  • Expression of amphetamine sensitization is associated with recruitment of a reactive neuronal population in the nucleus accumbens core.

    abstract:RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...


    pub_type: 杂志文章


    authors: Nordquist RE,Vanderschuren LJ,Jonker AJ,Bergsma M,de Vries TJ,Pennartz CM,Voorn P

    更新日期:2008-05-01 00:00:00

  • Molecular properties of monoamine oxidases A and B.

    abstract::Monoamine oxidases A and B (MAO-A and B) catalyze the oxidative catabolism of biogenic amines and xenobiotics. Investigation of these mitochondrial membrane proteins shows that they differ in substrate preference, inhibitor specificity, tissue and neuronal cell distribution, immunological properties, and nucleotide an...


    pub_type: 杂志文章


    authors: Kwan SW,Bergeron JM,Abell CW

    更新日期:1992-01-01 00:00:00

  • Reproductive experience alters the involvement of N-methyl-D-aspartate receptors in fear extinction, but not fear conditioning, in female Sprague Dawley rats.

    abstract::Recently, evidence has emerged showing that the behavioural and hormonal features of fear extinction are altered as a result of reproductive experience in both rats and humans. The current set of experiments sought to determine whether reproductive experience also alters the molecular features of fear extinction. In a...


    pub_type: 杂志文章


    authors: Tang S,Graham BM

    更新日期:2019-01-01 00:00:00