Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone.

Abstract:

:The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a much less effective inhibitor of strychnine convulsion. Methaqualone elicits muscle-relaxant, sedative, and anticonvulsant effects at different dose levels. At low, nonsedative doses the drug produces anticonvulsant effects, and at higher doses, muscle-relaxant and sedative effects. It appears that the mechanism(s) of action of methaqualone in on GABA deficiency or receptor blockade, rather than on glycine receptors.

journal_title

Psychopharmacology

authors

Naik SR,Naid PR,Sheth UK

doi

10.1007/BF00426965

subject

Has Abstract

pub_date

1978-04-14 00:00:00

pages

103-7

issue

1

eissn

0033-3158

issn

1432-2072

journal_volume

57

pub_type

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