Abstract:
:Low doses of 8-OH-DPAT (62.5-250 micrograms/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished the 8-OH-DPAT-induced place preference. However, neither PCPA nor pimozide altered the 8-OH-DPAT-induced place aversion. The results are consistent with other evidence showing that 8-OH-DPAT acts through different mechanisms at low and high doses, and support the hypothesis that low doses of 8-OH-DPAT act through 5-HT neurons to disinhibit dopaminergic activity.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Papp M,Willner Pdoi
10.1007/BF02244082subject
Has Abstractpub_date
1991-01-01 00:00:00pages
99-102issue
1eissn
0033-3158issn
1432-2072journal_volume
103pub_type
杂志文章abstract::The alcohol-preferring AA rats have previously been shown to drink more solution containing the opioid etonitazene than the alcohol-avoiding ANA rats. The present experiments were initiated to see whether the line difference in opioid and alcohol intake would persist if an intravenous (i.v.) route of self-administrati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247335
更新日期:1996-06-01 00:00:00
abstract::Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246290
更新日期:1995-06-01 00:00:00
abstract:RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0111-7
更新日期:2006-06-01 00:00:00
abstract::This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245224
更新日期:1994-01-01 00:00:00
abstract::It has previously been shown that serotonergic [5-hydroxytryptamine (5-HT)] neurons of the median raphe nucleus (MR) are critically involved in the control of the hippocampal electroencephalogram (EEG). Activation of MR 5-HT neurons desynchronizes the hippocampal EEG, whereas inhibition of MR 5-HT activity produces hi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02311170
更新日期:1995-08-01 00:00:00
abstract::In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05353-6
更新日期:2020-01-01 00:00:00
abstract:RATIONALE:Prepulse inhibition (PPI) represents a normal sensorimotor gating response that is typically impaired in schizophrenic patients. It is known that cannabinoid CB1 agonists reduce sensorimotor gating in rats, suggesting that the CB1 receptor and the cannabinoid system are involved in sensorimotor gating. OBJEC...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1851-5
更新日期:2004-09-01 00:00:00
abstract::A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppres...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02245590
更新日期:1995-09-01 00:00:00
abstract::In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remainin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464566
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Perospirone is a novel second-generation antipsychotic drug with high affinity to dopamine D(2) receptor and short half-life of plasma concentration. There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with peros...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1783-1
更新日期:2010-05-01 00:00:00
abstract:RATIONALE:Certain disorders, such as depression and anxiety, to which serotonin dysfunction is historically associated, are also associated with lower assessments of other people's trustworthiness. Serotonergic changes are known to alter cognitive responses to threatening stimuli. This effect may manifest socially as r...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3444-2
更新日期:2014-07-01 00:00:00
abstract:RATIONALE:Intermittent social defeat stress can induce neuroadaptations that promote compulsive drug taking. Within the mesocorticolimbic circuit, repeated cocaine administration activates extracellular signal-regulated kinase (ERK). OBJECTIVE:The present experiments examine whether changes in ERK phosphorylation are ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3796-7
更新日期:2015-05-01 00:00:00
abstract::Cholecystokinin (CCK) and dopamine (DA) coexist in both cell body and terminal areas of a mesolimbic pathway that projects from the ventral tegmental area (VTA) to the nucleus accumbens (N ACC). Autoradiography reveals extensive CCK binding sites in the N ACC, but not in the VTA. However, iontophoresis of CCK into the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445571
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Depression is a frequent non-motor symptom in Parkinson's disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1867-y
更新日期:2010-07-01 00:00:00
abstract:RATIONALE:The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects. OBJECTIVE:We review evidence from a series of experiments concerning an animal model that dissociates between the disruption of attentional capacities during acute illness periods...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-008-1216-6
更新日期:2009-01-01 00:00:00
abstract:RATIONALE:Second-generation antipsychotics occupy dopamine D2 receptors and act as antagonists or partial agonists at these receptors. While these drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating cognitive deficits and negative symptoms. Dopamine D3 receptors are hi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4382-y
更新日期:2016-10-01 00:00:00
abstract::Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N = 4) or agoraphobia with panic attacks (N = 17) and age- and sex-matched healthy subjects (N = 22). The patients showed a significantly lower number of beta-adrenergic receptor binding sites and a significantl...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00735875
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Dronabinol (Δ(9)tetrahydrocannabinol) is approved for HIV-related anorexia, yet, little is known about its effects in HIV-positive marijuana smokers. HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects. OBJECTIVES:Employing a within-subjects, double-...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1995-4
更新日期:2010-12-01 00:00:00
abstract:RATIONALE:Depressed patients robustly exhibit affective biases in emotional processing which are altered by SSRIs and predict clinical outcome. OBJECTIVES:The objective of this study is to investigate whether psilocybin, recently shown to rapidly improve mood in treatment-resistant depression (TRD), alters patients' e...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4754-y
更新日期:2018-02-01 00:00:00
abstract::This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was elicited by varying intensities of a tactile stimulus and the magnitudes of the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050820
更新日期:1999-01-01 00:00:00
abstract:RATIONALE:Executive function impairment, as classically assessed using the Wisconsin Card Sort Test or intradimensional/extradimensional tests, is a key feature of schizophrenia but remains inadequately treated by existing therapies. Recently, however, erythropoietin has been shown to improve attentional set-shifting p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1990-9
更新日期:2010-12-01 00:00:00
abstract::Two experiments were conducted to assess the acute behavioral effects of triazolam and temazepam in healthy, non-drug abusing men in double-blind, placebo-controlled, crossover trials, where all subjects received all possible doses. These drugs were compared to examine allegations that triazolam produces greater behav...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244887
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence indicating that OUD may be particularly severe for women, preclinical models have yet to establish sex as a major factor in OUD. OBJECTIVES:Here, we examined sex differences in vulnerability to relapse following intermittent access fe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05750-2
更新日期:2021-01-06 00:00:00
abstract:RATIONALE:The emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological symptoms has prompted the research on the consequences of acute and chronic use of these new psychoactive substances. Most studies on cannabinoid dependence have been per...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05704-8
更新日期:2021-02-01 00:00:00
abstract:RATIONALE:The dopaminergic system has been proposed to mediate alcohol-induced locomotor activity, yet the mechanisms underlying this behavioral response remain poorly understood. OBJECTIVES:This study was conducted to investigate the role of dopamine D2-like receptors in mediating alcohol-induced behavioral responses...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4264-3
更新日期:2016-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Because of the important role of dopamine in neurotransmission, it would be useful to be able to image brain dopamine receptor-mediated signal transduction in animals and humans. Administering the D1-D2 receptor agonist apomorphine may allow us to do this, as the D2-like receptor is reported to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1073-3
更新日期:2008-05-01 00:00:00
abstract:RATIONALE:Cannabidiol is a non-psychoactive phytocannabinoid with great therapeutic potential in diverse psychiatric disorders; however, its antidepressant potential has been mainly ascertained in adult rats. OBJECTIVES:To compare the antidepressant-like response induced by cannabidiol in adolescent and adult rats and...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05481-4
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS:Twelve participants ('dual users' of EC and cigarettes) used their own brand cigaret...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4512-6
更新日期:2017-03-01 00:00:00
abstract:RATIONALE:Antiepileptic drugs are known to produce side effects which may impair driving performance. Performance effects, however, may differ substantially between individual antiepileptic drugs. OBJECTIVE:To compare the effects of carbamazepine, remacemide, and placebo on actual driving performance during a 12-day i...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130100898
更新日期:2002-01-01 00:00:00
abstract::In experiment 1, rats (n = 12) were trained to discriminate the benzodiazepine (BDZ) compound chlordiazepoxide (CDP, 20 mg/kg, IP) from saline in a two-lever food-reinforced procedure, and subsequently were tested for stimulus control with different doses of CDP, Ro 15-1788 (a proposed BDZ receptor antagonist) and Ro ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00652236
更新日期:1986-01-01 00:00:00