Abstract:
RATIONALE:Dronabinol (Δ(9)tetrahydrocannabinol) is approved for HIV-related anorexia, yet, little is known about its effects in HIV-positive marijuana smokers. HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects. OBJECTIVES:Employing a within-subjects, double-blind, placebo-controlled design, we assessed the effects of repeated high-dose dronabinol in HIV-positive marijuana smokers taking antiretroviral medication. METHODS:Participants (N = 7), who smoked marijuana 4.2 ± 2.3 days/week, resided in a residential laboratory for two 16-day stays, receiving dronabinol (10 mg QID) in one stay and placebo in the other. Efficacy was assessed with objectively verified food intake and body weight. Tolerability was measured with sleep, subjective, and cognitive assessments. For analyses, each inpatient stay was divided into two phases, days 1-8 and 9-16; we compared dronabinol's effects with placebo in each 8-day phase to investigate tolerance. RESULTS:Despite sustained increases in self-reported food cravings, dronabinol only increased caloric intake in the initial 8 days of dosing. Similarly, sleep quality was improved only in the first 8 days of dosing. Dronabinol's mood-enhancing effects were sustained across the 16-day inpatient stay. Dronabinol was well tolerated, causing few negative subjective or cognitive effects. CONCLUSIONS:In HIV-positive marijuana smokers, high dronabinol doses safely and effectively increased caloric intake. However, repeated high-dose dronabinol appeared to result in selective tolerance to these effects. These findings indicate that HIV-positive individuals who smoke marijuana may require higher dronabinol doses than are recommended by the FDA. Future research to establish optimal dosing regimens, and reduce the development of tolerance, is required.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Bedi G,Foltin RW,Gunderson EW,Rabkin J,Hart CL,Comer SD,Vosburg SK,Haney Mdoi
10.1007/s00213-010-1995-4subject
Has Abstractpub_date
2010-12-01 00:00:00pages
675-86issue
4eissn
0033-3158issn
1432-2072journal_volume
212pub_type
杂志文章abstract::The effects of acute marijuana intoxication on remote memory and new learning were assessed. To test for the effects of marijuana on remote memory, titles of one-season television shows, aired up to 14 years previously, were used in three tests measuring recognition, temporal judgement and detailed recall of facts fro...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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