Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition.

abstract：:A double-blind, placebo-controlled, cross-over study in ten normal volunteers assessed the effects of the subcutaneous administration of adrenaline on platelet MAO activity, in an attempt to replicate previous findings of increased MAO activity following adrenaline. Platelet counts, cortisol plasma concentrations, and...

journal_title：Psychopharmacology

authors： Gentil V,McCurdy RL,Alevizos B,Lader MH

更新日期：1976-11-10 00:00:00

abstract：RATIONALE:Cocaine and opioids are often co-abused. As yet, however, there is no clear evidence that the drugs interact to make the mixture a more effective reinforcer. OBJECTIVE:The present study examined the relative reinforcing potency and maximum effectiveness of the cocaine-opioid combination in monkeys given a ch...

journal_title：Psychopharmacology

authors： Freeman KB,Woolverton WL

更新日期：2011-05-01 00:00:00

abstract：:We examined the possibility that anoxia at birth can alter behavioral sensitization to amphetamine during adulthood. Male rats born either vaginally or by Cesarean section with or without an additional 15-min period of anoxia received five once-daily injections of either d-amphetamine (2.0 mg/kg, i.p.) or vehicle or n...

journal_title：Psychopharmacology

authors： Brake WG,Boksa P,Gratton A

更新日期：1997-10-01 00:00:00

abstract：RATIONALE:Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated. OBJECTIVES:We examined the ingestive behavioral effects of MTII at the microstructural level using two complementary approaches. METHODS...

journal_title：Psychopharmacology

authors： Williams DL,Grill HJ,Weiss SM,Baird JP,Kaplan JM

更新日期：2002-04-01 00:00:00

abstract：:The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various an...

journal_title：Psychopharmacology

authors： Ramanathan M,Jaiswal AK,Bhattacharya SK

更新日期：1998-02-01 00:00:00

abstract：:Supersensitivity to serotonin during migraine attack has been previously observed. Since the attack has been attributed to a critical lowering of morphine-like factors, we can expect serotonin supersensitivity during morphine abstinence. Slight signs of morphine abstinence have also been induced in volunteers after mi...

journal_title：Psychopharmacology

authors： Sicuteri F,Del Bianco PL,Anselmi B

更新日期：1979-10-01 00:00:00

abstract：RATIONALE:A variety of behavioral procedures have been developed to assess cannabinoid activity in mice; however, the feasibility of establishing Delta(9)-THC as a discriminative stimulus in mice has not been documented. OBJECTIVE:One goal was to establish Delta(9)-THC as a discriminative stimulus in mice; after havin...

journal_title：Psychopharmacology

authors： McMahon LR,Ginsburg BC,Lamb RJ

更新日期：2008-07-01 00:00:00

abstract：RATIONALE:Lithium is the most widely prescribed mood stabilizer, but the precise mechanism of lithium is unresolved. OBJECTIVE:We examine the effects of the administration of therapeutically relevant concentrations of lithium on the expression of brain-derived neurotrophic factor (BDNF) and its receptor, Trk B, as wel...

journal_title：Psychopharmacology

authors： Fukumoto T,Morinobu S,Okamoto Y,Kagaya A,Yamawaki S

更新日期：2001-10-01 00:00:00

abstract：:Response decrements in an operant task produced by either extinction or by the dopamine receptor blocker pimozide were examined in three experiments which employed intermittent reinforcement schedules. In contrast to the congruency between these treatments previously observed following continuous reinforcement trainin...

journal_title：Psychopharmacology

authors： Tombaugh TN,Anisman H,Tombaugh J

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Schizophrenia is a severe, persistent, and fairly common mental illness. Haloperidol is widely used and is effective against the symptoms of psychosis seen in schizophrenia. Chronic oral haloperidol administration decreased the number of astrocytes in the parietal cortex of macaque monkeys (Konopaske et al., ...

journal_title：Psychopharmacology

authors： Konopaske GT,Bolo NR,Basu AC,Renshaw PF,Coyle JT

更新日期：2013-11-01 00:00:00

abstract：:The behavioral effects of the benzodiazepine (BZP)-receptor partial inverse agonists, beta-CCE and FG 7142, are reviewed and the claim that these compounds possess "anxiogenic" properties is examined. Results obtained from human studies and global observations in animals, as well as those from experiments on aggressio...

journal_title：Psychopharmacology

authors： Thiébot MH,Soubrié P,Sanger D

更新日期：1988-01-01 00:00:00

abstract：:The purpose of this study was to assess the effects of acute nicotine administration, following a 12-h cigarette deprivation period, using a computerized performance assessment battery (PAB). The PAB was comprised of five tasks which were selected to reflect a variety of complex acquired behaviors, sometimes referred ...

journal_title：Psychopharmacology

authors： Snyder FR,Henningfield JE

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Spontaneous fluctuations in the size of the pupil in darkness are a recognized index of sleepiness, and these fluctuations can be quantitatively measured using the pupillographic sleepiness test (PST). The central noradrenergic system is believed to play a role in the maintenance of alertness, and there is ev...

journal_title：Psychopharmacology

authors： Phillips MA,Szabadi E,Bradshaw CM

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...

journal_title：Psychopharmacology

authors： Abreu-Villaça Y,Filgueiras CC,Correa-Santos M,Cavina CC,Naiff VF,Krahe TE,Manhães AC,Ribeiro-Carvalho A

更新日期：2015-05-01 00:00:00

abstract：:Withdrawal was precipitated by naloxone at different intervals, up to 22.5 h, following a last maintenance injection in morphine-dependent rats. Different symptoms of withdrawal were found to be preeminent following different morphine-naloxone intervals. Locomotor activity, jumping, and writhing were precipitated most...

journal_title：Psychopharmacology

authors： Linseman MA

更新日期：1977-10-20 00:00:00

abstract：:Transdermal nicotine has been shown to relieve nicotine withdrawal and to double smoking cessation rates compared to placebo in clinical trials. A 21 or 22 mg/day dose provides a steady state serum nicotine that is less than obtained from smoking. Limited information is available about higher nicotine patch doses. To ...

journal_title：Psychopharmacology

authors： Fredrickson PA,Hurt RD,Lee GM,Wingender L,Croghan IT,Lauger G,Gomez-Dahl L,Offord KP

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:Smoking typically begins during adolescence and is largely reinforced by social cues. During adolescence in rats, sensitivity to both social cues and drugs of abuse is enhanced. OBJECTIVES:We have previously demonstrated in adolescent male rats that a low dose of cocaine interacts with social reward to produ...

journal_title：Psychopharmacology

authors： Thiel KJ,Sanabria F,Neisewander JL

更新日期：2009-06-01 00:00:00

abstract：:Chronic administration of the pre-synaptic alpha-adrenoreceptor agonist clonidine decreases the concentration of the extra-neuronal metabolite of noradrenaline normetanephrine in the amygdaloid cortex and increases it in the mid-brain. Conversely, blockade of these pre-synaptic receptors by yohimbine increases the nor...

journal_title：Psychopharmacology

authors： Fludder JM,Leonard BE

更新日期：1979-09-01 00:00:00

abstract：:The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in an...

journal_title：Psychopharmacology

authors： Darragh A,Lambe R,O'Boyle C,Kenny M,Brick I

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:The characterization of self-administration (SA) under extended access conditions is necessary for the development of addiction models. OBJECTIVE:The purposes of this experiment were to investigate: (1) dose effects on the initiation of cocaine SA under extended access conditions; (2) predictable individual ...

journal_title：Psychopharmacology

authors： Mantsch JR,Ho A,Schlussman SD,Kreek MJ

更新日期：2001-08-01 00:00:00

abstract：:Methaqualone produces a dose- and time-dependent increase in plasma corticosterone concentration in mice. Acute studies showed that this effect is largely independent of methaqualone-induced hypothermia but can be blocked by pretreatment with dexamethasone, thus demonstrating that the adrenal cortex is not being direc...

journal_title：Psychopharmacology

authors： Meyer JS,Boggan WO

更新日期：1977-08-31 00:00:00

abstract：:The ability of mu and kappa opioids to alter the discriminative-stimulus and rate-decreasing effects of the 5-HT1A receptor agonist 8-OH-DPAT was examined in rats trained to discriminate either a low (0.1 mg/kg) or a high (0.3 mg/kg) dose of 8-OH-DPAT from water using a two-lever food-reinforced drug discrimination pr...

journal_title：Psychopharmacology

authors： Morgan D,Picker MJ

更新日期：1995-12-01 00:00:00

abstract：:The development of a differential tolerance to morphine was investigated with respect to the mean effective dose, the threshold dose of tolerance, the degree of tolerance after a fixed dose, and the speed of tolerance loss. The mean effective doses, the threshold doses of tolerance, and the degree of tolerance differe...

journal_title：Psychopharmacology

authors： Fernandes M,Kluwe S,Coper H

更新日期：1982-01-01 00:00:00

abstract：:The opioid antagonist effects of systemically administered nor-binaltorphimine (nor-BNI) were evaluated against the kappa agonists CI-977, U69,593, U50,488, ethylketocyclazocine (EKC), Mr2034 and bremazocine, the mu agonist morphine and the alkaloid delta agonist BW-373U86 in the acetic acid-induced writhing assay in ...

journal_title：Psychopharmacology

authors： Broadbear JH,Negus SS,Butelman ER,de Costa BR,Woods JH

更新日期：1994-07-01 00:00:00

abstract：RATIONALE:Comorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented. OBJECTIVE:The purpose of our study was to examine the influence of genetic alcohol drinking tendency on reward-guided decision making behavior of rats and the impact of dopamine releaser D-amphetamine on this behavior....

journal_title：Psychopharmacology

authors： Oinio V,Sundström M,Bäckström P,Uhari-Väänänen J,Kiianmaa K,Raasmaja A,Piepponen P

更新日期：2018-05-01 00:00:00

abstract：RATIONALE:Exercise stimulates the release of endogenous opioid peptides and increases nociceptive (i.e. pain) thresholds in both human and animal subjects. During chronic, long-term exercise, sensitivity to the effects of morphine and other mu opioids decreases, leading some investigators to propose that exercise may l...

journal_title：Psychopharmacology

authors： Smith MA,Yancey DL

更新日期：2003-08-01 00:00:00

abstract：RATIONALE:Depression is a frequent non-motor symptom in Parkinson's disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is ...

journal_title：Psychopharmacology

authors： Felicio AC,Moriyama TS,Godeiro-Junior C,Shih MC,Hoexter MQ,Borges V,Silva SM,Amaro-Junior E,Andrade LA,Ferraz HB,Bressan RA

更新日期：2010-07-01 00:00:00

abstract：:We have previously demonstrated that depletion of forebrain norepinephrine (NE) led to an attenuation of neophobia in a novel environment, as defined by a greater preference for novel food over familiar food. To study further the role of forebrain NE in neophobia we chronically infused noradrenergic receptor ligands o...

journal_title：Psychopharmacology

authors： Steketee JD,Silverman PB,Swann AC

更新日期：1992-01-01 00:00:00

abstract：:The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring System. In the cocain...

journal_title：Psychopharmacology

authors： Rocha BA,Odom LA,Barron BA,Ator R,Wild SA,Forster MJ

更新日期：1998-07-01 00:00:00

abstract：RATIONALE:Successive negative contrast (SNC) describes a change in the behaviour of an animal following a downshift in the quantitative or qualitative value of an expected reward. This behavioural response has been hypothesised to be linked to affective state, with negative states associated with larger and/or prolonge...

journal_title：Psychopharmacology

authors： Phelps CE,Mitchell EN,Nutt DJ,Marston HM,Robinson ES

更新日期：2015-08-01 00:00:00