Extinction and dopamine receptor blockade after intermittent reinforcement training: failure to observe functional equivalence.

abstract：RATIONALE:An important goal of addiction research is to discover neurobiological markers that could predict the severity of addiction and help to determine appropriate treatment. Brain-derived neurotrophic factor (BDNF) and thiobarbituric acid reactive substances (TBARS) are being related to cerebral plasticity and imp...

journal_title：Psychopharmacology

authors： Sordi AO,Pechansky F,Kessler FH,Kapczinski F,Pfaffenseller B,Gubert C,de Aguiar BW,de Magalhães Narvaez JC,Ornell F,von Diemen L

更新日期：2014-10-01 00:00:00

abstract：:Rhesus monkeys were trained in a discrete-trials choice procedure and allowed to choose between intravenous injections of cocaine (0.01-1.0 mg/kg/injection) and food presentation (1 or 4 pellets; 1 g/pellet) during daily 7-h experimental sessions. When each reinforcer was available under a fixed-ratio (FR) 30 schedule...

journal_title：Psychopharmacology

authors： Nader MA,Woolverton WL

更新日期：1992-01-01 00:00:00

abstract：:The purpose of this study was to determine whether repeated treatment (15 days) with d-amphetamine (AMP) or fenfluramine (FEN), administered after a daily 3 h feeding session (e.g. post-session), would result in tolerance or cross-tolerance to the decrement in food consumption induced by treatment with either drug bef...

journal_title：Psychopharmacology

authors： Hunsinger RN,Barnes TB,Kapeghian JC,Wilson MC

更新日期：1981-01-01 00:00:00

abstract：:This study evaluated the effects of two central nicotinic-cholinergic receptor agonists and an antagonist on performance accuracy of a rat, delayed stimulus discrimination task (DSDT). Rats were trained to discriminate between an auditory and visual stimulus by pressing a right or left lever. To diminish the rat's abi...

journal_title：Psychopharmacology

authors： Terry AV Jr,Buccafusco JJ,Jackson WJ,Zagrodnik S,Evans-Martin FF,Decker MW

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...

journal_title：Psychopharmacology

authors： Nagaraja N,Andrade C,Sudha S,Madan Singh N,Chandra JS,Venkataraman BV

更新日期：2007-01-01 00:00:00

abstract：RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...

journal_title：Psychopharmacology

authors： McKee SA,O'Malley SS,Shi J,Mase T,Krishnan-Sarin S

更新日期：2008-02-01 00:00:00

abstract：:Serotonin (5-HT) afferents may modulate the dopamine mesoaccumbens circuit, which has been shown to be critically involved in the locomotor stimulatory, discriminative stimulus, and rewarding properties of cocaine. In the present study, we investigated the role of 5-HT1A receptors in the ventral tegmental area (VTA) i...

journal_title：Psychopharmacology

authors： De La Garza R 2nd,Callahan PM,Cunningham KA

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:To compare matched paliperidone-ER- and olanzapine-treated schizophrenic patients on measures of glucose and lipid metabolism. METHODS:Eighty hospitalized patients with schizophrenia (DSM-IV) were randomly assigned to treatment with paliperidone ER or olanzapine for a period of 12 weeks. At baseline and ever...

journal_title：Psychopharmacology

authors： Hu S,Yao M,Peterson BS,Xu D,Hu J,Tang J,Fan B,Liao Z,Yuan T,Li Y,Yue W,Wei N,Zhou W,Huang M,Xu Y

更新日期：2013-11-01 00:00:00

abstract：:Different venlafaxine doses (1, 5, and 10 mg/kg) and saline solution were administered to ten male Wistar rats (Latin-Square design). Compared with saline, venlafaxine produced a dose-related suppression of REM sleep and an increase in wake time while slow wave sleep was reduced. This effect is similar to the one that...

journal_title：Psychopharmacology

authors： Salin-Pascual RJ,Moro-Lopez ML

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF...

journal_title：Psychopharmacology

authors： Zhen YF,Zhang J,Liu XY,Fang H,Tian LB,Zhou DH,Kosten TR,Zhang XY

更新日期：2013-05-01 00:00:00

abstract：RATIONALE:Electrophysiological studies have identified a scalp potential, the late positive potential (LPP), which is modulated by the emotional intensity of observed stimuli. Previous work has shown that the LPP reflects the modulation of activity in extrastriate visual cortical structures, but little is known about t...

journal_title：Psychopharmacology

authors： de Rover M,Brown SB,Boot N,Hajcak G,van Noorden MS,van der Wee NJ,Nieuwenhuis S

更新日期：2012-02-01 00:00:00

abstract：:Rats were chronically administered either haloperidol (HAL) or fluphenazine (FLU) via depot injections for 8 months, given these same drugs in their drinking water for the next 2 months, and then withdrawn from the drugs. Throughout the experiment the animals were tested repeatedly in an enclosed tube using a computer...

journal_title：Psychopharmacology

authors： See RE,Levin ED,Ellison GD

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Alcohol drinking may lead to increased aggression in certain individuals, and both fighting and drinking increase levels of dopamine and serotonin in mesocorticolimbic structures. Assessing the dynamic changes in these neurotransmitters during the course of drinking and fighting has remained challenging. OB...

journal_title：Psychopharmacology

authors： van Erp AM,Miczek KA

更新日期：2007-04-01 00:00:00

abstract：:Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval...

journal_title：Psychopharmacology

authors： Piccirillo M,Alpert JE,Cohen DJ,Shaywitz BA

更新日期：1980-01-01 00:00:00

abstract：:In the rat, lysergic acid diethylamide (LSD) 0.5 mg/kg and 2-bromo lysergic acid diethylamide (BOL) 0.5 mg/kg increased the rate of the striatal in vivo tyrosine hydroxylation as measured by the DOPA accumulation after decarboxylase inhibition. Neither LSD nor BOL significantly changed the DOPA accumulation in the olf...

journal_title：Psychopharmacology

authors： Persson SA

更新日期：1978-10-31 00:00:00

abstract：RATIONALE:Acid sensing ion channels (ASICs) are proton-gated ion channels located in the central and peripheral nervous systems. Of particular interest is ASIC1a, which is located in areas associated with fear and anxiety behaviors. Recent reports suggest a role for ASIC1a in preclinical models of fear conditioning and...

journal_title：Psychopharmacology

authors： Dwyer JM,Rizzo SJ,Neal SJ,Lin Q,Jow F,Arias RL,Rosenzweig-Lipson S,Dunlop J,Beyer CE

更新日期：2009-03-01 00:00:00

abstract：RATIONALE:Several studies have demonstrated that males with a family history of alcoholism (FHP) show less of a response to alcohol (e.g. lower ratings of intoxication) than males without a family history of alcoholism (FHN). The purpose of this pilot study was to determine if FHP females also showed a reduced sensitiv...

journal_title：Psychopharmacology

authors： Evans SM,Levin FR

更新日期：2003-08-01 00:00:00

abstract：RATIONALE:Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction. OBJ...

journal_title：Psychopharmacology

authors： Panlilio LV,Thorndike EB,Schindler CW

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:Gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. Sex differences have also been observed in the antinociceptive effects of opioid agonis...

journal_title：Psychopharmacology

authors： Negus SS,Mello NK

更新日期：2002-01-01 00:00:00

abstract：RATIONALE:An increased risk of drug intake produced by drug cues may reflect the fact that the cues are withdrawal-like or aversive, reflecting a conditioned adaptation to the drug's acute effects. More recent work suggests that they may also be appetitive, signalling the goal characteristics of drug taking. OBJECTIVE...

journal_title：Psychopharmacology

authors： Mucha RF,Geier A,Pauli P

更新日期：1999-12-01 00:00:00

abstract：:While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...

journal_title：Psychopharmacology

authors： Wood RD,Tirelli E,Snyder KJ,Heyser CJ,LaRocca TM,Spear LP

更新日期：1998-07-01 00:00:00

abstract：:Nefiracetam is undergoing preclinical and clinical tests as a cognition-enhancing drug in Alzheimer's disease (AD). Nicotinic cholinergic receptors are lost in AD, and nicotinic as well as muscarinic cholinergic receptors are involved in the modulation of eyeblink conditioning. Experiments were carried out using young...

journal_title：Psychopharmacology

authors： Woodruff-Pak DS,Hinchliffe RM

更新日期：1997-05-01 00:00:00

abstract：RATIONALE:In drug-dependent individuals, the primary excessive motivation is for drugs. Studies also indicate altered interest for "natural" rewarding activities associated with motivational disorders that may be relevant to drug dependence. However, to date, the impact of drug dependence and withdrawal upon motivation...

journal_title：Psychopharmacology

authors： Rouibi K,Contarino A

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:The primary aim of this project was to examine the role of alcohol use in smoking lapse behavior, as alcohol consumption is a known risk factor for poor smoking cessation outcomes. MATERIALS AND METHODS:We have developed a novel human laboratory model to examine two primary aspects of alcohol-mediated tobacc...

journal_title：Psychopharmacology

authors： McKee SA,Krishnan-Sarin S,Shi J,Mase T,O'Malley SS

更新日期：2006-12-01 00:00:00

abstract：:In order to study experimental alcohol intake that leads to heightened aggression, we established ethanol self-administration in aggressive rats. The focus was on low doses of self-administered ethanol and to assess their effects on aggressive behavior in resident rats, using a limited access paradigm followed by a 5-...

journal_title：Psychopharmacology

authors： van Erp AM,Miczek KA

更新日期：1997-06-01 00:00:00

abstract：:The study compares the behavioral profiles induced in rats (N = 118) by the D2-dopaminergic receptor agonist quinpirole (0.03 and 0.5 mg/kg), and the D1-agonist SKF38393 (1.25-40 mg/kg), and both agonists administered together. Locomotion and snout contact frequency were reduced by the low but increased by the high do...

journal_title：Psychopharmacology

authors： Eilam D,Talangbayan H,Canaran G,Szechtman H

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...

journal_title：Psychopharmacology

authors： Linn GS,Lifshitz K,O'Keeffe RT,Lee K,Camp-Lifshitz J

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:(+/-) 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine analog and drug of abuse. In animals, MDMA damages brain serotonin (5-HT) neurons at doses that overlap with those used recreationally by some humans. To date, few functional sequelae of MDMA-induced 5-HT damage have been identified. ...

journal_title：Psychopharmacology

authors： McCann UD,Mertl M,Eligulashvili V,Ricaurte GA

更新日期：1999-04-01 00:00:00

abstract：RATIONALE:While reserpine-induced oral movements (OM), an animal model of tardive dyskinesia, are more persistent in old than in adult rats, old animals present spontaneous OM, which are phenomenologically similar to those presented by reserpine-treated adult rats. We postulate that these OM may be the result of oxidat...

journal_title：Psychopharmacology

authors： Abílio VC,Vera JA Jr,Ferreira LS,Duarte CR,Carvalho RC,Grassl C,Martins CR,Torres-Leite D,Bignotto M,Tufik S,Ribeiro Rde A,Frussa-Filho R

更新日期：2002-06-01 00:00:00

abstract：RATIONALE:Several recent studies have focused on glutamate modulating agents for symptoms relief in schizophrenia, especially negative symptoms which are resistant to conventional therapies. OBJECTIVES:We aimed to assess the efficacy and tolerability of riluzole, an anti-glutamate agent with neuroprotective properties...

journal_title：Psychopharmacology

authors： Farokhnia M,Sabzabadi M,Pourmahmoud H,Khodaie-Ardakani MR,Hosseini SM,Yekehtaz H,Tabrizi M,Rezaei F,Salehi B,Akhondzadeh S

更新日期：2014-02-01 00:00:00