Abstract：
RATIONALE:Electrophysiological studies have identified a scalp potential, the late positive potential (LPP), which is modulated by the emotional intensity of observed stimuli. Previous work has shown that the LPP reflects the modulation of activity in extrastriate visual cortical structures, but little is known about the source of that modulation. OBJECTIVES:The present study investigated whether beta-adrenergic receptors are involved in the generation of the LPP. METHODS:We used a genetic individual differences approach (experiment 1) and a pharmacological manipulation (experiment 2) to test the hypothesis that the LPP is modulated by the activation of β-adrenergic receptors. RESULTS:In experiment 1, we found that LPP amplitude depends on allelic variation in the β1-receptor gene polymorphism. In experiment 2, we found that LPP amplitude was modulated by the β-blocker propranolol in a direction dependent on subjects' level of trait anxiety: In participants with lower trait anxiety, propranolol led to a (nonsignificant) decrease in the LPP modulation; in participants with higher trait anxiety, propranolol increased the emotion-related LPP modulation. CONCLUSIONS:These results provide initial support for the hypothesis that the LPP reflects the downstream effects, in visual cortical areas, of β-receptor-mediated activation of the amygdala.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
de Rover M,Brown SB,Boot N,Hajcak G,van Noorden MS,van der Wee NJ,Nieuwenhuis Sdoi
10.1007/s00213-011-2426-xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
971-9issue
4eissn
0033-3158issn
1432-2072journal_volume
219pub_type
杂志文章,随机对照试验abstract：:The effect of lithium and rubidium on curiosity rearing, and locomotor activity in isolated and group-housed male mice (DBA/2 Han) was investigated. LiCl and RbCl were given with the drinking water (30 mol/l) during 3 weeks. The behaviour of the animals was tested before and after the chronical application of either l...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432270
更新日期：1979-03-28 00:00:00
abstract：:This study examined the effects of intrahippocampal injections of scopolamine (a muscarinic antagonist drug) on performance of a working-memory task (contingently reinforced T-maze alternation) and a reference-memory task (visual discrimination) by the same rats in the same maze. Rats in the first shipment were traine...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427569
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards. OBJECTIVES:Experiment 1 investigated whet...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1779-x
更新日期：2010-04-01 00:00:00
abstract：RATIONALE:Cessation of daily caffeine consumption produces a withdrawal syndrome comprised of subjective symptoms and functional impairment. Few controlled studies have examined the physiological effects of caffeine withdrawal. OBJECTIVE:The present study examined the effect of caffeine withdrawal on cerebral blood fl...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050005
更新日期：2000-01-01 00:00:00
abstract：:A study was performed on the effect of ethanol on the basal and K+-evoked efflux of endogenous GABA from rat hypothalamic fragments. The amount of GABA present in the medium and in the tissue was measured by radioreceptor assay. In vitro addition of ethanol (50 and 100 mM) enhanced the K+-evoked efflux of GABA in a Ca...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00181959
更新日期：1988-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244238
更新日期：1990-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1326-5
更新日期：2003-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1947-z
更新日期：2010-10-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442235
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Stressful life events are suggested to contribute to the development of various pathologies, such as cardiovascular disorders, whose etiopathogenesis is highly associated with elevated levels of serum amyloid A (SAA) proteins. SAA synthesis in the liver is regulated by a complex network of cytokines acting in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5149-4
更新日期：2019-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4754-y
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0666-y
更新日期：2007-04-01 00:00:00
abstract：:Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeuti...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00429689
更新日期：1979-05-25 00:00:00
abstract：RATIONALE:Acute alcohol intoxication induces a selective impairment of recognition memory associated with conscious recollection whilst recognition based on familiarity is left intact. OBJECTIVES:We aimed to further elucidate the acute effects of alcohol on recognition memory by assessing three different doses of alco...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1709-y
更新日期：2010-01-01 00:00:00
abstract：RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3940-z
更新日期：2015-08-01 00:00:00
abstract：:Research was conducted to examine the ability of alcohol to impart conditioned reinforcement. Rats were allowed to self-administer solutions of either saline or alcohol (25, 50, and 100 mg/kg/infusion) by the intragastric route. Superimposed on the infusion interval was a buzzer (conditioned reinforcing stimulus). Tes...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00492355
更新日期：1977-08-16 00:00:00
abstract：RATIONALE:Approximately 20 million adults in the USA have an alcohol use disorder (AUD). There are clinical and preclinical data suggesting that psychedelics may have benefits for AUD. OBJECTIVE:To investigate the effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on the behavioral effects of e...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05328-7
更新日期：2019-12-01 00:00:00
abstract：RATIONALE:The majority of pharmacotherapies proposed for cocaine dependence have been marginally effective and frequently have undesirable side effects. We recently demonstrated that short-term treatment with citicoline decreased self-reported desire to use cocaine in crack cocaine users. OBJECTIVE:The present study w...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130100824
更新日期：2001-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-007-0884-y
更新日期：2007-11-01 00:00:00
abstract：:The predatory behavior of ferrets (Putorius putorius furo L.) consists mainly of instinctive behavioral patterns that are elicited by simple external stimuli. For the ferret, the time needed to catch and kill rats depends on the size of the rats in relation to that of the ferret. Killing success decreases with a relat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427754
更新日期：1978-10-31 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2814-x
更新日期：2013-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245152
更新日期：1992-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00172861
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Understanding the mechanisms responsible for stress-induced relapse is important for guiding treatment strategies aimed at minimizing the contribution of stress to addiction. Evidence suggests that these mechanisms involve interactions between noradrenergic systems and the neuropeptide corticotropin-releasing...
journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
abstract：:The benzodiazepine diazepam and the benzodiazepine antagonist Ro 15-1788 were tested alone or in combination for their influence on scopolamine-induced locomotor stimulation in mice. The benzodiazepine antagonist had no effect by itself, but prevented the enhancement of scopolamine-induced locomotor stimulation produc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00464583
更新日期：1982-01-01 00:00:00
abstract：:This study describes specific behaviours in guinea-pigs after dopamine D-1 and D-2 receptor activation which differed to those described in other rodent species. Intraperitoneal (IP) administration of the dopamine D-2 receptor agonist quinpirole (1.5, 3 and 6 mg/kg) to guinea-pigs dose-dependently initiated locomotor ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244179
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Reelin, a large extracellular matrix glycoprotein, is down-regulated in the brain of schizophrenic patients and of heterozygous reeler mice (rl/+). The behavioral phenotype of rl/- mice, however, matches only partially the schizophrenia hallmarks. OBJECTIVES:We recently reported (Marrone et al., Eur J Neuros...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1483-x
更新日期：2009-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1983-01-01 00:00:00
abstract：RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3713-0
更新日期：2015-02-01 00:00:00
abstract：:The number of nerve cells in two different areas of the corpus striatum (i.e., ventrolateral and dorsomedial) was estimated in rat brain after long-term (36 weeks) treatment with the neuroleptic flupenthixol. Nine rats were given weekly injections of 4 mg/kg flupenthixol dissolved in Viscoleo i.m., and seven rats rece...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428036
更新日期：1978-09-15 00:00:00
