Abstract:
RATIONALE:Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction. OBJECTIVES:This study examined the ability of response-independent reinforcer delivery (priming) to reinstate food- or drug-reinforced responding that had been suppressed by response-contingent footshock (punishment). METHODS:Nose-poke responding by separate groups of rats was reinforced with food (45 mg/delivery) or intravenous remifentanil (4 micro g/kg per infusion), a short-acting micro -opioid agonist. After either 3 or 27 days of training (with 100 reinforcers/day), a punishment contingency was introduced that rapidly suppressed responding. Then, the punishment contingency was discontinued, and half the rats received priming. RESULTS:Priming by non-contingent delivery of food or remifentanil significantly reduced the number of sessions required for responding to resume. There were no significant differences in this effect between short-term and long-term training or between food- and drug-trained groups. CONCLUSIONS:Self-administration responding that has been suppressed by punishment can be reinstated by priming, and it can eventually resume even without priming. Under the conditions studied here, priming after punishment had effects qualitatively similar to those typically seen after extinction. This punishment/reinstatement procedure may be useful for comparing the effects of other manipulations known to affect behavior in the extinction/reinstatement model of relapse.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Panlilio LV,Thorndike EB,Schindler CWdoi
10.1007/s00213-002-1193-0subject
Has Abstractpub_date
2003-07-01 00:00:00pages
229-235issue
1-2eissn
0033-3158issn
1432-2072pii
10.1007/s00213-002-1193-0journal_volume
168pub_type
杂志文章abstract:RATIONALE:Pre-clinical and clinical studies have suggested that the antidepressant efficacy of escitalopram (ESC) can be augmented by co-administration of aripiprazole (ARI). OBJECTIVE:To establish if the effects of ESC + ARI can be altered by modulating the 5-HT1a receptor. METHODS:Sprague-Dawley male rats received ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05225-z
更新日期:2019-07-01 00:00:00
abstract:RATIONALE:We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. OBJECTIVES:The aim of this study was to evaluate the effect of Valeriana officinalis root extract on preventio...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3716-x
更新日期:2015-03-01 00:00:00
abstract:RATIONALE:Preclinical studies indicate that gonadal hormones are important determinants of drug self-administration. To date, little is known about the influence of sex and estrous cycle on drug self-administration in ecologically relevant social contexts. OBJECTIVE:The objective of this study was to examine the role ...
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pub_type: 杂志文章
doi:10.1007/s00213-016-4368-9
更新日期:2016-09-01 00:00:00
abstract::Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245521
更新日期:1993-01-01 00:00:00
abstract::The pharmacokinetic and pharmacodynamic effects of concomitant administration of alprazolam and fluoxetine were studied in this double-blind parallel study in 80 healthy, male volunteers. Subjects were randomly assigned to one of four treatment groups. Drug treatments consisted of 4-day regimens of 1 mg alprazolam fou...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Dopamine (DA) and glutamate (Glu) interactions in the mesocorticolimbic pathway may regulate motivation and reward and contribute to schizophrenia and drug abuse. We have recently demonstrated synergistic effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor blockade and ...
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pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
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更新日期:2013-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/s00213-008-1388-0
更新日期:2009-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1995-06-01 00:00:00
abstract:RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacqui...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2003-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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doi:10.1007/s00213-009-1560-1
更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00427106
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0627-5
更新日期:2007-03-01 00:00:00
abstract::Changes in saccadic eye movements before and after up to 10 mg oral diazepam were measured electrooculographically in diazepam-naive humans. Diazepam produced dose-dependent increases in saccade duration and decreases in maximum saccade velocity over a 2--36 degrees range of saccade amplitudes. The magnitude of drug-i...
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pub_type: 临床试验,杂志文章
doi:10.1007/BF00427100
更新日期:1981-01-01 00:00:00
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更新日期:1996-11-01 00:00:00
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更新日期:2016-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-06-01 00:00:00
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更新日期:2019-05-01 00:00:00
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更新日期:2005-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-007-0908-7
更新日期:2007-12-01 00:00:00
abstract::Maternal pup searching behaviour of lactating house mice treated with apomorphine, haloperidol or saline was examined on a running board with a central depression as a nest. Pup searching was elicited by artificial ultrasonic stimuli: a female moved out from the nest either towards a 50 kHz tone (key stimulus) which i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174523
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1977-11-15 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1607-3
更新日期:2009-10-01 00:00:00
abstract::Single doses of amantadine hydrochloride and placebo were administered in a double-blind cross-over design on separate days to ten actively craving cocaine abusers in treatment. Pharmacological treatment did influence cocaine craving, but amantadine was less effective than placebo. ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00439458
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse. OBJECTIVES:To examine the effect of sub-chronic administration of hydrocortisone on the response to amphetamine in healthy male volunteers. METHODS:Following baseline assessment, 20 volunteers were...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-02-01 00:00:00