Mecamylamine- or scopolamine-induced learning impairment: ameliorated by nefiracetam.

abstract：:The subjective, psychomotor, and physiological effects of analgesic doses of oral codeine and morphine were examined in 12 healthy volunteers. Subjects ingested placebo, morphine 20 or 40 mg, or codeine 60 or 120 mg in a randomized, double-blind, crossover design. The smaller and larger doses of each drug were putativ...

journal_title：Psychopharmacology

authors： Walker DJ,Zacny JP

更新日期：1998-11-01 00:00:00

abstract：:The novel dopamine autoreceptor antagonists (-)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (-)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (-)-DS 121 produce...

journal_title：Psychopharmacology

authors： Smith A,Piercey M,Roberts DC

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injectio...

journal_title：Psychopharmacology

authors： Lu L,Dempsey J

更新日期：2004-10-01 00:00:00

abstract：:The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...

journal_title：Psychopharmacology

authors： Rebec GV,White IM,Puotz JK

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...

journal_title：Psychopharmacology

authors： Harun N,Johari IS,Mansor SM,Shoaib M

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this assoc...

journal_title：Psychopharmacology

authors： Zhang XY,Liang J,Chen DC,Xiu MH,Yang FD,Kosten TA,Kosten TR

更新日期：2012-07-01 00:00:00

abstract：RATIONALE:Comorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented. OBJECTIVE:The purpose of our study was to examine the influence of genetic alcohol drinking tendency on reward-guided decision making behavior of rats and the impact of dopamine releaser D-amphetamine on this behavior....

journal_title：Psychopharmacology

authors： Oinio V,Sundström M,Bäckström P,Uhari-Väänänen J,Kiianmaa K,Raasmaja A,Piepponen P

更新日期：2018-05-01 00:00:00

abstract：:The behavioral responsiveness to challenge doses of the D2 agonist quinpirole was examined in 21-day-old normal offspring (experiment 1) as well as offspring exposed gestationally to cocaine (experiment 2). In both experiments weanling rats received a subcutaneous injection of 0 (0.9% saline), 0.04, 0.08, 0.5, or 1.0 ...

journal_title：Psychopharmacology

authors： Moody CA,Frambes NA,Spear LP

更新日期：1992-01-01 00:00:00

abstract：:Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...

journal_title：Psychopharmacology

authors： Dooley DJ,Bowden DM

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Each year, over 300,000 individuals in the USA enter treatment for cannabis use disorder (CUD). The development of effective pharmacotherapy for CUD is a priority. OBJECTIVE:This placebo-controlled study examined the effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a labo...

journal_title：Psychopharmacology

authors： Herrmann ES,Cooper ZD,Bedi G,Ramesh D,Reed SC,Comer SD,Foltin RW,Haney M

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:The endogenous opioid system has been implicated in substance abuse and response to pharmacotherapies for nicotine and alcohol addiction. We examined (1) the association of the functional OPRM1 A118G variant with the relative reinforcing value of nicotine and (2) the main and interacting effects of the mu-opi...

journal_title：Psychopharmacology

authors： Ray R,Jepson C,Patterson F,Strasser A,Rukstalis M,Perkins K,Lynch KG,O'Malley S,Berrettini WH,Lerman C

更新日期：2006-10-01 00:00:00

abstract：:Lithium elicits opposite effects on two behavioural syndromes in rats: enhancement of the 5-HT1A-linked serotonin syndrome and attenuation of the 5-HT2-linked wet dog shakes. The ability of intracerebroventricular (ICV) myo-inositol or forskolin to reverse the enhancement of the serotonin syndrome by lithium was teste...

journal_title：Psychopharmacology

authors： Kofman O,Levin U

更新日期：1995-03-01 00:00:00

abstract：:The capacity of the specific narcotic antagonists naltrexone and naloxone to block the discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete-trial avoidance task. The antagonists produced a dose-dependent and time-dependent blockade of morphine's effects as measured by resp...

journal_title：Psychopharmacology

authors： Shannon HE,Holtzman SG

更新日期：1976-11-10 00:00:00

abstract：RATIONALE:The phenomenon of sensitization has been theoretically implicated in mediating various aspects of drug addiction. Recent dose-response studies demonstrated that pretreatment with the putative antiaddictive agent, ibogaine (IBO), and a synthetic iboga alkaloid congener, 18-methoxycoronaridine (18-MC), increase...

journal_title：Psychopharmacology

authors： Szumlinski KK,Balogun MY,Maisonneuve IM,Glick SD

更新日期：2000-08-01 00:00:00

abstract：:It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...

journal_title：Psychopharmacology

authors： Welsch-Kunze S,Kuschinsky K

更新日期：1990-01-01 00:00:00

abstract：:The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and nighttime experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of met...

journal_title：Psychopharmacology

authors： Risch C,Kripke D,Janowsky D

更新日期：1980-01-01 00:00:00

abstract：INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...

journal_title：Psychopharmacology

authors： Koethe D,Hoyer C,Leweke FM

更新日期：2009-11-01 00:00:00

abstract：:Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later supe...

journal_title：Psychopharmacology

authors： Willner P,McGuirk J,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...

journal_title：Psychopharmacology

authors： Concas A,Sogliano C,Porcu P,Marra C,Brundu A,Biggio G

更新日期：2006-06-01 00:00:00

abstract：:Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the upper and low lips using TV images. The human observer data indicated that during HAL administration the total dur...

journal_title：Psychopharmacology

authors： Ellison G,See R,Levin E,Kinney J

更新日期：1987-01-01 00:00:00

abstract：:The effects of the enantiomers of 3-PPP on the maintenance of conditioned avoidance responding (CAR) were studied. The weak classical dopamine (DA) agonist (+)-3-PPP failed to interfere with CAR at any dose tested (0.8-13.6 mg/kg). Low doses of the drug produced sedation, while high doses produced behavioural stimulat...

journal_title：Psychopharmacology

authors： Clark D,Carlsson A,Hjorth S,Engel J,Lindberg P

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Little is known about patterns of opiate use by heroin addicts. OBJECTIVES:To describe opiate use over time among heroin addicts who had access to legally prescribed intravenous heroin and oral opiates. METHODS:Analysis of daily drug administration records of 37 patients enrolled in the Geneva heroin mainte...

journal_title：Psychopharmacology

authors： Perneger TV,Mino A,Giner F,Broers B

更新日期：2000-09-01 00:00:00

abstract：:The present study was undertaken to evaluate the effects of single and repeated doses of triazolam (1 mg/kg IP) and desipramine (DMI) (10 mg/kg IP) alone and in combination on certain pharmacologic responses and brain catecholamine levels in rats. The significant findings were: (1) triazolam and DMI given alone and in...

journal_title：Psychopharmacology

authors： Kusaka M,Horikawa A,Meshi T,Maruyama Y

更新日期：1980-01-01 00:00:00

abstract：:The discriminative stimulus (DS) effect of apomorphine was investigated in rats trained in a two-lever, food-reinforcement procedure. Rats were given subcutaneous injections of saline or 0.1 mg/kg apomorphine HCl, 15 min before training sessions. The training dose of apomorphine was chosen to activate dopamine autorec...

journal_title：Psychopharmacology

authors： Tang AH,Franklin SR

更新日期：1987-01-01 00:00:00

abstract：INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...

journal_title：Psychopharmacology

authors： King A,McNamara P,Conrad M,Cao D

更新日期：2009-11-01 00:00:00

abstract：:N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...

journal_title：Psychopharmacology

authors： Coward DM,Doggett NS

更新日期：1977-04-29 00:00:00

abstract：RATIONALE:Negative mood states are characterized by both stress hormone dysregulation and serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-HTT) levels. However, so far, no study examined the individual association between cortisol response and cerebral in vivo 5-HTT levels in patients su...

journal_title：Psychopharmacology

authors： Reimold M,Knobel A,Rapp MA,Batra A,Wiedemann K,Ströhle A,Zimmer A,Schönknecht P,Smolka MN,Weinberger DR,Goldman D,Machulla HJ,Bares R,Heinz A

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:Developmental lead exposure may alter responsiveness to cocaine well into adulthood, and ultimately influence drug-use patterns. OBJECTIVES:The present study examined the effect of perinatal lead exposure on the discriminative stimulus properties of cocaine. METHODS:Female rats were treated with 0, 8, or 16...

journal_title：Psychopharmacology

authors： Miller DK,Nation JR,Bratton GR

更新日期：2001-11-01 00:00:00

abstract：RATIONALE:Alcohol intoxication produces effects that can impair judgment and increase engagement in risky behaviors, including alcohol-impaired driving (AID). Real-world AID decisions are informed by contextual circumstances and judgments of associated risk. How individuals vary in their AID decision-making across cont...

journal_title：Psychopharmacology

authors： Motschman CA,Warner OM,Wycoff AM,Davis-Stober CP,McCarthy DM

更新日期：2020-12-01 00:00:00

abstract：:The present report investigated several parametric and pharmacological aspects of the enhanced self-grooming behavior of rats following systemic administration of the selective D1 dopamine (DA) receptor agonist SKF 38393. The amount of time that rats spent grooming themselves was measured continuously for 30 min follo...

journal_title：Psychopharmacology

authors： Wachtel SR,Brooderson RJ,White FJ

更新日期：1992-01-01 00:00:00