Abstract:
RATIONALE:The endogenous opioid system has been implicated in substance abuse and response to pharmacotherapies for nicotine and alcohol addiction. We examined (1) the association of the functional OPRM1 A118G variant with the relative reinforcing value of nicotine and (2) the main and interacting effects of the mu-opioid receptor antagonist naltrexone on nicotine reinforcement. METHODS:In a within-subject, double-blind human laboratory study, 30 smokers of each OPRM1 genotype (A/A vs. A/G or G/G) participated in two experimental sessions following 4 days of orally administered naltrexone 50 mg or placebo. Participants completed a validated assessment of the relative reinforcing value of nicotine. This cigarette choice paradigm assesses self-administration of 0.6 mg nicotine vs. 0.05 mg (denicotinized) cigarettes after a brief period of nicotine abstinence. RESULTS:The relative reinforcing value of nicotine (number of nicotine cigarette puffs) was predicted by a significant OPRM1 by gender interaction. Among women, the low-activity G allele (A/G and G/G) was associated with a reduced reinforcing value of nicotine; among male smokers, there was no association with genotype. Smokers carrying a G allele were also significantly less likely to differentiate the nicotine vs. denicotinized cigarettes by subjective ratings of satisfaction and strength. No evidence for an effect of naltrexone on nicotine reinforcement was found in the overall sample or in the genotype or gender subgroups. CONCLUSIONS:This study provides initial evidence for an association of the OPRM1 A118G variant with nicotine reinforcement in women.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ray R,Jepson C,Patterson F,Strasser A,Rukstalis M,Perkins K,Lynch KG,O'Malley S,Berrettini WH,Lerman Cdoi
10.1007/s00213-006-0504-2subject
Has Abstractpub_date
2006-10-01 00:00:00pages
355-63issue
3eissn
0033-3158issn
1432-2072journal_volume
188pub_type
杂志文章abstract:RATIONALE:The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards. OBJECTIVES:Experiment 1 investigated whet...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1779-x
更新日期:2010-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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abstract:RATIONALE:The five-choice serial reaction time task (5-CSRTT) is regularly used to study attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial interval (ITI), a light appears in one of five holes. Responding in the lit vs. unlit hole reflects attention (accuracy), while respondi...
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更新日期:2016-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::The effects of long-term amphetamine treatment were evaluated on responding supported by self-stimulation of the substantia nigra. Rats repeatedly treated with d-amphetamine, and tested with a low dose of the drug that ordinarily has no behavioral effect, showed higher response rates than animals repeatedly treated wi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426653
更新日期:1980-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442814
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-21 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5107-1
更新日期:2019-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1982-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00176480
更新日期:1987-01-01 00:00:00