Abstract：
:The behavioral responsiveness to challenge doses of the D2 agonist quinpirole was examined in 21-day-old normal offspring (experiment 1) as well as offspring exposed gestationally to cocaine (experiment 2). In both experiments weanling rats received a subcutaneous injection of 0 (0.9% saline), 0.04, 0.08, 0.5, or 1.0 mg/kg/3 cc of the D2 agonist quinpirole and were placed in a divided glass testing apparatus containing either a dish of wet mash plus a food pellet or wood block (experiment 1) or both a food pellet and a wood block (experiment 2). Behaviors were recorded for 5 min via time-sampling at 30 and 60 min post-injection. In experiment 1 the three highest doses of quinpirole increased the amount of forward locomotion, rearing, sniffing and probing, as well as increasing directed oral movements at both the wood block and food pellet; in general these findings are reminiscent of those reported previously in adult animals. In experiment 2, cocaine-exposed weanlings exhibited an increased sensitivity to the stimulating effects of a low dose of the D2 agonist for forward locomotion and rearing as well as an increase in the overall incidence of sniffing behavior and chewing on food pellets. These data provide psychopharmacological evidence that the increase in striatal D2 binding previously observed in weanling offspring exposed gestationally to cocaine (Scalzo et al. 1990) may be associated with an increased behavioral sensitivity to the D2 agonist quinpirole.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Moody CA,Frambes NA,Spear LPdoi
10.1007/BF02245109subject
Has Abstractpub_date
1992-01-01 00:00:00pages
256-62issue
3eissn
0033-3158issn
1432-2072journal_volume
108pub_type
杂志文章abstract：RATIONALE:The P3 is a ubiquitous component of stimulus-driven neural activity that can be observed in scalp electrophysiological recordings. Multiple lines of evidence suggest an important role for the noradrenergic system in the generation of the P3. However, pharmacological studies of the P3 using noradrenergic manip...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-015-3966-2
更新日期：2015-09-01 00:00:00
abstract：:It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244064
更新日期：1990-01-01 00:00:00
abstract：:A technique is described for studying exploratory as well as stereotyped behaviour in rats using an automated hole-board. Both visual and automated recordings can be employed using the technique. Hole dipping is monitored automatically using an infra-red detector system. Repetitive patterns of hole-dipping are used as...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426711
更新日期：1977-05-09 00:00:00
abstract：:Few studies have examined the association between ethanol use and cigarette smoking topography. In particular, no study has objectively investigated the relationship between chronic ethanol exposure and cigarette smoking. The aim of this study was to quantify the relationship between cigarette smoking and past and cur...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245794
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Clinical trials show that chronic cocaine users suffer from sleep disturbances and preclinical research has shown that acute sleep deprivation increases the rate of cocaine self-administration in rats. OBJECTIVE:This study examined the effect of cocaine self-administration on behavioral indices of sleep and ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3101-1
更新日期：2013-09-01 00:00:00
abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-001-0955-4
更新日期：2002-03-01 00:00:00
abstract：:Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439445
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Morphine and buprenorphine have analgesic and anxiolytic-like properties. While their analgesic effects have been well characterized, their anxiolytic-like properties have not. OBJECTIVES:Effects of acute morphine and buprenorphine on the expression of acoustic fear-potentiated startle (FPS) and naloxone pre...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1112-0
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:This study aims to conduct an evidence review of the effectiveness, harms, and cost-effectiveness of pharmacogenomics-guided antidepressant treatment for major depressive disorder. METHODS:We searched MEDLINE®, the Cochrane Central Registry of Controlled Trials, and PsycINFO through February 2017. We used pr...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-017-4622-9
更新日期：2017-06-01 00:00:00
abstract：RATIONALE:Each year, over 300,000 individuals in the USA enter treatment for cannabis use disorder (CUD). The development of effective pharmacotherapy for CUD is a priority. OBJECTIVE:This placebo-controlled study examined the effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a labo...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-016-4298-6
更新日期：2016-07-01 00:00:00
abstract：:In a placebo-controlled study, we investigated the influence of nicotine on late-day aviation performance in 15 non-smoking subjects. In a within-subjects design, subjects were tested on 2 days, each lasting 8 h and consisting of three 75-min simulator flights (late-afternoon practice, evening test, night test). Prior...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130050736
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:Traumatic events are associated with alcohol use problems with increased alcohol craving as a potential mediator. There is still a lack of knowledge regarding the causal nature of this association and its underlying mechanisms. This study investigated the effects of acute trauma exposure on alcohol craving i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-4979-4
更新日期：2018-10-01 00:00:00
abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0434-z
更新日期：2006-09-01 00:00:00
abstract：:Dosage regimen adjustments because of poor renal function are often assumed to be unnecessary for extensively metabolized antidepressants. This assumption is being increasingly questioned in recognition of the role of active drug metabolites. The purpose of this study was to assess the steady-state accumulation of the...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02412111
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Premature discontinuation of antidepressant drugs is a frequent clinical problem. Adverse effects are common, occur early on in treatment and are reported to be one of the main reasons for discontinuation of antidepressant treatment. OBJECTIVES:To investigate the association between adverse effects occurring...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-014-3467-8
更新日期：2014-08-01 00:00:00
abstract：:Rats may produce ultrasonic vocalizations (USV) in threatening situations. USV of adult male rats in association with aversive stimulation was evaluated as a screening method for anxiolytic drugs. The triazolobenzodiazepine alprazolam, the 5-HT uptake inhibitors fluvoxamine and clomipramine, the mixed 5-HT/NA uptake i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245095
更新日期：1995-01-01 00:00:00
abstract：RATIONALE:Little is known about patterns of opiate use by heroin addicts. OBJECTIVES:To describe opiate use over time among heroin addicts who had access to legally prescribed intravenous heroin and oral opiates. METHODS:Analysis of daily drug administration records of 37 patients enrolled in the Geneva heroin mainte...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130000492
更新日期：2000-09-01 00:00:00
abstract：RATIONALE:Subthreshold smokers (who smoke < or =5 cigarettes/day) experience withdrawal symptoms, yet they smoke less than is required to maintain serum nicotine levels. OBJECTIVES:For study 1, our aim was to determine (1) if adult subthreshold smokers report withdrawal symptoms; (2) how they rate symptom severity; (3...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0497-x
更新日期：2006-10-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:We previously found that systemic injections of the 5-HT uptake blocker fluoxetine attenuate intermittent footshock stress-induced reinstatement of alcohol seeking in rats, while inhibition of 5-HT neurons in the median raphe induces reinstatement of alcohol seeking. In this study, we further e...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0346-y
更新日期：2006-05-01 00:00:00
abstract：:Effects of chlordiazepoxide (CDP) and ethanolamine-O-sulphate (EOS) alone and in combination were tested on the acquisition and performance of continuous reinforcement - time out (CR-TO) and variable interval reinforcement - time out (VI-TO) operant discriminations in rats. CDP disrupted acquisition of CR-TO discrimin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00310620
更新日期：1986-01-01 00:00:00
abstract：:Dose-related effects of ethanol (placebo, 0.30, and 0.60 g/kg) on behavioral and event-related brain potential (ERP) indices of involuntary attention shifting of audition were investigated. ERPs were recorded from 11 healthy social drinkers during a forced-choice reaction-time (RT) task. Subjects were presented with 1...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050801
更新日期：1999-01-01 00:00:00
abstract：:After learning a light-cued, go-no go successive discrimination to criterion, male Sprague-Dawley rats received 0, 5, or 10 mg/kg chlordiazepoxide on six performance sessions, followed by two drug-recovery (saline) sessions. Chlordiazepoxide impaired discrimination performance in a dose-dependent manner, with animals ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00652237
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differenti...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-019-05246-8
更新日期：2019-09-01 00:00:00
abstract：:Four macaques with lesions of dorsolateral frontal cortex and 4 normal monkeys were injected with 1 mg/kg d-amphetamine. Observations of social behaviors and motor activity were conducted over a 1-month period. The results of this experiment show a partial dissociation of effects of amphetamines on behavior of normal ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428704
更新日期：1976-05-05 00:00:00
abstract：:The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050563
更新日期：1998-04-01 00:00:00
abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") causes serotonin neuron damage in laboratory animals. The serotonin system is known to be important in the regulation of mood. Previous research has shown that MDMA users score higher on self-report ratings of depression than controls. However, MDMA users ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1705-6
更新日期：2004-05-01 00:00:00
abstract：:During the third week of life, a hyperactive period for laboratory rat, the occurrence of 8 behavioral categories was recorded in individual littermates transferred to a novel environment. Neonatal destruction of the catecholaminergic system by intraventricular injection of 6-OH-DA resulted in increased motor activity...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426882
更新日期：1978-04-28 00:00:00
abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a potent and selective serotonin neurotoxin whose use is growing among adolescents. Although cognitive deficits among adult MDMA users are well documented, little is known of the cognitive and brain functional sequelae of MDMA use during adolescence. OBJ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1679-4
更新日期：2004-05-01 00:00:00
abstract：RATIONALE:Many addictive drugs are known to have effects on learning and memory, and these effects could motivate future drug use. Specifically, addictive drugs may affect memory of emotional events and experiences in ways that are attractive to some users. However, few studies have investigated the effects of addictiv...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-012-2924-5
更新日期：2013-04-01 00:00:00
abstract：:The effects on one-way active avoidance conditioning of pre-training, systemic administration of the selective mu-receptor agonist [D-Ala2,N-Me-Phe4, Gly-ol]enkephalin (DAGO), and the selective mu-receptor antagonist (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP), were determined in Swiss-Webster mice. A low dose of ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245494
更新日期：1992-01-01 00:00:00
