Abstract:
:After learning a light-cued, go-no go successive discrimination to criterion, male Sprague-Dawley rats received 0, 5, or 10 mg/kg chlordiazepoxide on six performance sessions, followed by two drug-recovery (saline) sessions. Chlordiazepoxide impaired discrimination performance in a dose-dependent manner, with animals in the 5 mg/kg dose condition demonstrating tolerance to the drug after two performance sessions. The degree of discrimination impairment in both drug dose conditions paralleled an increase in responding during no-go phases of the performance task. These findings are consistent with a "disinhibitory hypothesis" of performance impairment and suggest that CDP-drugged animals have difficulty in withholding incorrect responses.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Cole SO,Michaleski Adoi
10.1007/BF00652237subject
Has Abstractpub_date
1986-01-01 00:00:00pages
184-6issue
2eissn
0033-3158issn
1432-2072journal_volume
88pub_type
杂志文章abstract:RATIONALE:We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome. OBJECTIVES:This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cess...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-017-4580-2
更新日期:2017-06-01 00:00:00
abstract:RATIONALE:We have recently shown that post-extinction exposure of rats to a sub-threshold reminder shock can reactivate extinguished context-related freezing and found that chronic treatment with fluoxetine before fear extinction prevents this phenomenon. OBJECTIVES:In the present study, we examined whether these find...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2134-y
更新日期:2011-05-01 00:00:00
abstract:RATIONALE:Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis. OBJECTIVES:The present study investigates whether event-related potentials (ERPs) differ between occasional and heavy cannabis users after acute Δ9-tetrahydrocannabinol (THC) administration, as a result of to...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2479-x
更新日期:2012-03-01 00:00:00
abstract:RATIONALE/OBJECTIVES:Both the neuropeptide S (NPS) system and antagonism at the adenosine A2A receptor (e.g., by caffeine) were found to play a crucial role in the mediation of arousal and anxiety/panic in animal and human studies. Furthermore, a complex interaction of the neuropeptide S and the adenosinergic system ha...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2678-0
更新日期:2012-08-01 00:00:00
abstract:RATIONALE:The mechanism involved in AD is complex, which has prompted to develop compounds that could simultaneously interact with several potential targets. Here, we report a new synthesized compound SCR-1693 which is designed to target both AChE and calcium channels that are potential for AD therapy. OBJECTIVES:We i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4133-5
更新日期:2016-02-01 00:00:00
abstract:RATIONALE:The characterization of self-administration (SA) under extended access conditions is necessary for the development of addiction models. OBJECTIVE:The purposes of this experiment were to investigate: (1) dose effects on the initiation of cocaine SA under extended access conditions; (2) predictable individual ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100744
更新日期:2001-08-01 00:00:00
abstract::The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445554
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Some recent pharmacoepidemiological studies revealed an elevated risk of driving accidents after opioid analgesics uses. Among analgesics, codeine is often associated with paracetamol in numerous pharmaceutical specialties. OBJECTIVES:The objective of this study was to evaluate the dose-effect relationship o...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3035-7
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram, was studied and compared with citalopram and the R-(-)-enantiomer, R-citalopram. METHODS:Inhibition of the serotonin transporter (5-HTT) was studied in COS-1 cells expressing the human 5-HTT (h-5-HTT) and in rat brain synaptosom...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1364-z
更新日期:2003-06-01 00:00:00
abstract:RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000422
更新日期:2000-06-01 00:00:00
abstract::Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later supe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245933
更新日期:1990-01-01 00:00:00
abstract::Paradoxical sleep (PS) in the rat, cat and mouse is preceded and sometimes followed by a short-lasting intermediate stage (IS) characterized by high amplitude cortical spindles and low frequency theta rhythm. This stage, which is mimicked by an intercollicular transection, is massively extended at the expense of PS by...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245333
更新日期:1994-11-01 00:00:00
abstract::The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.1 mg/kg IV), or placebo prior to 0.3 mg/kg IV amphetamine. Healthy volunteers (N = 12) partici...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00427446
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:The exact behavioral nature of drug-induced reinstatement of drug seeking is still debated. As an incentive, the drug can have general facilitatory influences on appetitive behaviors. As an interoceptive stimulus, the drug can acquire discriminative properties and control behavior. OBJECTIVE:This study asses...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1083-1
更新日期:2008-05-01 00:00:00
abstract::Chronic exposure to very mild unpredictable stress has previously been found to depress the consumption of, and preference for, highly palatable sweet solutions. The present study used the place conditioning procedure to investigate whether these effects result from a decreased sensitivity to reward. Rats were subject...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244188
更新日期:1991-01-01 00:00:00
abstract::The role of the nucleus accumbens septi (ACB) and corpus striatum (CPU) in self-stimulation were investigated by injecting directly or indirectly acting stimulant drugs or a dopamine-(DA)-receptor blocking agent into each site bilaterally. d-Amphetamine (68 nmol) facilitated hypothalamic self-stimulation when injected...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426546
更新日期:1977-08-31 00:00:00
abstract::Rhesus monkeys were trained in a discrete-trials choice procedure and allowed to choose between intravenous injections of cocaine (0.01-1.0 mg/kg/injection) and food presentation (1 or 4 pellets; 1 g/pellet) during daily 7-h experimental sessions. When each reinforcer was available under a fixed-ratio (FR) 30 schedule...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245115
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-3423-z
更新日期:2014-09-01 00:00:00
abstract:RATIONALE:The integrity of cortical cholinergic transmission is vital to attentional processing. A growing literature suggests that alterations in attentional processing accompany addictive drug use. This study examined the effects of acute and repeated administration of nicotine on cortical acetylcholine release. OBJ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1260-6
更新日期:2003-02-01 00:00:00
abstract:RATIONALE:Buprenorphine is a low-efficacy mu opioid agonist that can reduce drug taking in opioid abusers; however, the mechanism by which buprenorphine modifies the actions of other drug taking and the consequences of repeated treatment with buprenorphine are not fully understood. OBJECTIVE:The purposes of this study...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-001-0943-8
更新日期:2002-03-01 00:00:00
abstract:RATIONALE:The P3 is a ubiquitous component of stimulus-driven neural activity that can be observed in scalp electrophysiological recordings. Multiple lines of evidence suggest an important role for the noradrenergic system in the generation of the P3. However, pharmacological studies of the P3 using noradrenergic manip...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-015-3966-2
更新日期:2015-09-01 00:00:00
abstract::Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00555210
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:State-dependent changes in physiological arousal may influence impulsive behaviours. OBJECTIVES:To examine the relationship between arousal and impulsivity, we assessed the effects of yohimbine (an α2-adrenergic receptor antagonist, which increases physiological arousal via noradrenaline release) on performa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5160-9
更新日期:2019-06-01 00:00:00
abstract::The effects of various psychomotor stimulant drugs and drugs outside this class were examined on the efficacy of stimuli previously paired with reinforcement or reward (conditioned reinforcers, CR) in controlling responding. Pipradrol (5-45 mumol/kg), d-amphetamine (1.25-15.0 mumol/kg), and the cocaine analogues WIN 3...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427952
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Rivastigmine patches are used for patients with Alzheimer's disease (AD), but little is known about the serum concentration of rivastigmine and its metabolite or clinical adherence in relation to skinfold thickness after rivastigmine patch application. OBJECTIVES:The aim of this study was to examine the asso...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5135-x
更新日期:2019-04-01 00:00:00
abstract::The metabolism of the tricyclic antidepressants amitriptyline (AMI), imipramine (IMI), chlorimipramine (CMI) and some of their metabolites was studied in vitro in isolated liver microsomes of female Spraque-Dawley rats. Nine metabolites of AMI, seven metabolites of IMI, and 11 metabolites of CMI were quantitatively de...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00178516
更新日期:1986-01-01 00:00:00
abstract::After publication of this paper, the authors determined an error in Fig. 2C. ...
journal_title:Psychopharmacology
pub_type: 已发布勘误
doi:10.1007/s00213-019-05269-1
更新日期:2019-07-01 00:00:00
abstract:RATIONALE:It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1647-z
更新日期:2004-03-01 00:00:00
abstract:RATIONALE:Clinical trials show that chronic cocaine users suffer from sleep disturbances and preclinical research has shown that acute sleep deprivation increases the rate of cocaine self-administration in rats. OBJECTIVE:This study examined the effect of cocaine self-administration on behavioral indices of sleep and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3101-1
更新日期:2013-09-01 00:00:00
abstract::EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244335
更新日期:1993-01-01 00:00:00