Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication.

abstract：:Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the upper and low lips using TV images. The human observer data indicated that during HAL administration the total dur...

journal_title：Psychopharmacology

authors： Ellison G,See R,Levin E,Kinney J

更新日期：1987-01-01 00:00:00

abstract：:The discriminative stimulus (DS) effect of apomorphine was investigated in rats trained in a two-lever, food-reinforcement procedure. Rats were given subcutaneous injections of saline or 0.1 mg/kg apomorphine HCl, 15 min before training sessions. The training dose of apomorphine was chosen to activate dopamine autorec...

journal_title：Psychopharmacology

authors： Tang AH,Franklin SR

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram, was studied and compared with citalopram and the R-(-)-enantiomer, R-citalopram. METHODS:Inhibition of the serotonin transporter (5-HTT) was studied in COS-1 cells expressing the human 5-HTT (h-5-HTT) and in rat brain synaptosom...

journal_title：Psychopharmacology

authors： Sánchez C,Bergqvist PB,Brennum LT,Gupta S,Hogg S,Larsen A,Wiborg O

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Several theories propose alternative explanations for drug addiction. OBJECTIVES:We propose a general theory of transition to addiction that synthesizes knowledge generated in the field of addiction into a unitary explanatory frame. MAJOR PRINCIPLES OF THE THEORY:Transition to addiction results from a sequ...

journal_title：Psychopharmacology

authors： Piazza PV,Deroche-Gamonet V

更新日期：2013-10-01 00:00:00

abstract：:Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however, that pretreatment with systemic injections of AMPH does produce a significant enhancement in the locomotor stimulant effec...

journal_title：Psychopharmacology

authors： Paulson PE,Robinson TE

更新日期：1991-01-01 00:00:00

abstract：:Active uptake of serotonin by blood platelets of acute schizophrenic patients has been compared to that of a control group. Preliminary results presented in this article indicate that the uptake of the schizophrenic patients was about 40% lower than that of controls. Patients were followed over a period of 5 weeks wit...

journal_title：Psychopharmacology

authors： Modai I,Rotman A,Munitz H,Tjano S,Wijsenbeek H

更新日期：1979-08-08 00:00:00

abstract：:Cortical and hippocampal EEGs in animal models of schizophrenia were compared to those obtained with psychotomimetics or antipsychotic agents by utilizing power spectral analysis. Models of positive schizophrenic symptoms were created with methamphetamine (MAP) and cocaine, and a model of both negative and positive sy...

journal_title：Psychopharmacology

authors： Yamamoto J

更新日期：1997-06-01 00:00:00

abstract：:Herrnstein's matching equation was used to analyze drug effects on performance in random interval reinforcement schedules. Pimozide caused effects compatible with both motor and motivational impairments, in a 5-component multiple schedule, a 3-schedule 3-day cycle (ALT-3), and a 2-schedule 2-day cycle (ALT-2). However...

journal_title：Psychopharmacology

authors： Willner P,Sampson D,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：:Two groups of socially housed rhesus monkeys were raised under conditions differing in the degree of control or mastery over appetitive stimuli (food, water, and treats) in the 1st year of life. At age 18-24 months, a benzodiazepine receptor inverse agonist, beta-carboline-3-carboxylic acid ethyl ester (beta-CCE), was...

journal_title：Psychopharmacology

authors： Insel TR,Scanlan J,Champoux M,Suomi SJ

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Group I metabotropic glutamate receptor antagonists, which block both the mGlu1 and mGlu5 receptors, have been shown to have anxiolytic effects in the lick suppression test in rats. OBJECTIVE:The anxiolytic potential of the selective mGlu1 antagonist 3,4-dihydro-2H-pyrano[2,3]beta-quinolin-7-yl)(cis-4-methox...

journal_title：Psychopharmacology

authors： Steckler T,Lavreysen H,Oliveira AM,Aerts N,Van Craenendonck H,Prickaerts J,Megens A,Lesage AS

更新日期：2005-04-01 00:00:00

abstract：:The effects of olanzapine [LY 170053; 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2, 3b] [1,5]benzodiazepine), a potential atypical antipsychotic, were determined in pigeons whose keypeck responding was punished. These effects were compared to the anxiolytic agents chlordiazepoxide and pentobarbital, and to other a...

journal_title：Psychopharmacology

authors： Benvenga MJ,Leander JD

更新日期：1995-05-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...

journal_title：Psychopharmacology

authors： Yang F,Wang K,Du X,Deng H,Wu HE,Yin G,Ning Y,Huang X,Teixeira AL,de Quevedo J,Soares JC,Li X,Lang X,Zhang XY

更新日期：2019-02-01 00:00:00

abstract：RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...

journal_title：Psychopharmacology

authors： Cardoso C,Ellenbogen MA,Linnen AM

更新日期：2012-04-01 00:00:00

abstract：RATIONALE:Though interoceptive properties of antidepressants have been described, discriminative stimulus (DS) properties of mirtazapine, which does not affect monoamine reuptake, remain uncharacterized. OBJECTIVES:The objectives of the study are to train rats to recognize a mirtazapine DS, then perform substitution s...

journal_title：Psychopharmacology

authors： Dekeyne A,Millan MJ

更新日期：2009-04-01 00:00:00

abstract：:7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly ...

journal_title：Psychopharmacology

authors： Alfredsson G,Lindberg M,Sedvall G

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...

journal_title：Psychopharmacology

authors： Russig H,Murphy CA,Feldon J

更新日期：2003-09-01 00:00:00

abstract：RATIONALE:Zidovudine (AZT) and lamivudine (3TC) are nucleoside analogues administered prenatally in clinical practice, separately or in combination, as antiretroviral drugs to prevent HIV mother-to-child transmission by inhibiting viral reverse transcriptase. In animal studies pre- and/or perinatal exposure to AZT and ...

journal_title：Psychopharmacology

authors： Ricceri L,Venerosi A,Valanzano A,Sorace A,Alleva E

更新日期：2001-02-01 00:00:00

abstract：:Male Sprague-Dawley rats weighing 116--241 g were injected i.p. with ketamine hydrochloride, 80 mg per kilo of body weight. Immediately after loss of righting reflex, scopolamine, physostigmine, and mecamylamine were administered i.p. to different groups of rats. Control animals received sterile saline by the same rou...

journal_title：Psychopharmacology

authors： Figallo EM,Wingard LB Jr

更新日期：1979-03-14 00:00:00

abstract：:Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and ha...

journal_title：Psychopharmacology

authors： Jerussi TP,Glick SD

更新日期：1976-06-23 00:00:00

abstract：RATIONALE:Several studies have demonstrated that males with a family history of alcoholism (FHP) show less of a response to alcohol (e.g. lower ratings of intoxication) than males without a family history of alcoholism (FHN). The purpose of this pilot study was to determine if FHP females also showed a reduced sensitiv...

journal_title：Psychopharmacology

authors： Evans SM,Levin FR

更新日期：2003-08-01 00:00:00

abstract：RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...

journal_title：Psychopharmacology

authors： Braden BB,Garcia AN,Mennenga SE,Prokai L,Villa SR,Acosta JI,Lefort N,Simard AR,Bimonte-Nelson HA

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:Prior activation of the kappa opioid system by repeated stress or agonist administration has been previously shown to potentiate the rewarding properties of subsequently administered cocaine. In the present study, intermittent and uncontrollable footshock, a single session of forced swim, or acute administ...

journal_title：Psychopharmacology

authors： Redila VA,Chavkin C

更新日期：2008-09-01 00:00:00

abstract：RATIONALE:Preclinical evidence suggests that non-cannabinoid neurotransmitter systems are involved in the behavioral and physiological effects of cannabinoids, but relatively little research has been conducted in humans. OBJECTIVES:The aims of this study were to assess whether oral Delta(9)-tetrahydrocannabinol (Delta...

journal_title：Psychopharmacology

authors： Lile JA,Kelly TH,Pinsky DJ,Hays LR

更新日期：2009-04-01 00:00:00

abstract：:Preclinical and clinical research supports a role for neuroactive steroids in the pathophysiology of posttraumatic stress disorder (PTSD). We investigated ganaxolone (a synthetic 3β-methylated derivative of allopregnanolone, a GABAergic neuroactive steroid) for treatment of PTSD in a proof-of-concept, multisite, doubl...

journal_title：Psychopharmacology

authors： Rasmusson AM,Marx CE,Jain S,Farfel GM,Tsai J,Sun X,Geracioti TD,Hamner MB,Lohr J,Rosse R,Summerall L,Naylor JC,Cusin C,Lang AJ,Raman R,Stein MB

更新日期：2017-08-01 00:00:00

abstract：:The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling...

journal_title：Psychopharmacology

authors： Iwamoto ET

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Dronabinol (Δ(9)tetrahydrocannabinol) is approved for HIV-related anorexia, yet, little is known about its effects in HIV-positive marijuana smokers. HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects. OBJECTIVES:Employing a within-subjects, double-...

journal_title：Psychopharmacology

authors： Bedi G,Foltin RW,Gunderson EW,Rabkin J,Hart CL,Comer SD,Vosburg SK,Haney M

更新日期：2010-12-01 00:00:00

abstract：:The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a single reinforced trial. Male albino rats were trained to traverse a straight-alley for a reinforcer consisting of a single IV injection of 0.06 mg/kg diacetylmorph...

journal_title：Psychopharmacology

authors： Ettenberg A,MacConell LA,Geist TD

更新日期：1996-04-01 00:00:00

abstract：RATIONALE:Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed. OBJECTIVES:We investigated the effects of baclofen (study 1) and mirtazapine (study 2) in a human laboratory model of marijuana intoxication, withdrawa...

journal_title：Psychopharmacology

authors： Haney M,Hart CL,Vosburg SK,Comer SD,Reed SC,Cooper ZD,Foltin RW

更新日期：2010-08-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:We previously found that systemic injections of the 5-HT uptake blocker fluoxetine attenuate intermittent footshock stress-induced reinstatement of alcohol seeking in rats, while inhibition of 5-HT neurons in the median raphe induces reinstatement of alcohol seeking. In this study, we further e...

journal_title：Psychopharmacology

authors： Lê AD,Funk D,Harding S,Juzytsch W,Fletcher PJ,Shaham Y

更新日期：2006-05-01 00:00:00

abstract：:This study was conducted in order to investigate the level of amitriptyline (AT) and its metabolites. Three separate experiments were carried out. In two of these experiments, rats were treated over 7 days with IP doses of AT (10 mg/kg in experiment A and 2 X 20 mg/kg in experiment C). The rats were sacrificed either ...

journal_title：Psychopharmacology

authors： Baumann P,Gaillard JM,Jonzier-Perey M,Gerber C,Bouras C

更新日期：1984-01-01 00:00:00