Abstract:
:The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling, sniffing behavior and locomotion, and decreased rearing behavior. l-NAN decreased rearing activity, depressed locomotion, antagonized morphine antinociception and precipitated the morphine-withdrawal syndrome. Sensitization to drug-induced sniffing, rearing and locomotion developed after four daily injections of PCP, d-NAN or l-NAN in rats. Rats which were sensitized to PCP-induced locomotion, sniffing, and rearing were also cross-sensitized to both d-NAN and l-NAN. Animals sensitized to the effects of either d- or l-NAN exhibited cross-sensitization to PCP. There was little evidence that the cross-sensitization between the three agents was stereoselective. These data indicate that the acute effects of PCP are similar to those of d-NAN, but differ from l-NAN, the only agent of the three with opioid antagonist properties. The data further indicate that as sensitization to the motor effects develops during repeated administration of PCP, d-NAN or l-NAN, the differences among the three agents become less apparent.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Iwamoto ETdoi
10.1007/BF00310633subject
Has Abstractpub_date
1986-01-01 00:00:00pages
221-9issue
2eissn
0033-3158issn
1432-2072journal_volume
89pub_type
杂志文章abstract::Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426485
更新日期:1977-07-18 00:00:00
abstract:RATIONALE:Pediatric bipolar disorder (PBD) is a chronic and debilitating psychiatric illness. It is associated with many short-term and long-term complications including poor academic and social performance, legal problems and increased risk of suicide. Moreover, it is often complicated by other serious psychiatric dis...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0569-y
更新日期:2007-03-01 00:00:00
abstract::Nine VA Medical Centers are participating in a 2-year double-blind placebo controlled study of antioxidant treatment for tardive dyskinesia (TD) conducted by the Department of Veteran Affairs Cooperative Studies Program. One of the principal outcome measures of this study is the score derived from the instrumental ass...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s002130050320
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:To compare matched paliperidone-ER- and olanzapine-treated schizophrenic patients on measures of glucose and lipid metabolism. METHODS:Eighty hospitalized patients with schizophrenia (DSM-IV) were randomly assigned to treatment with paliperidone ER or olanzapine for a period of 12 weeks. At baseline and ever...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3073-1
更新日期:2013-11-01 00:00:00
abstract::Cocaine and amphetamine produce several behavioral effects, most notably locomotor stimulation. Biochemically, evidence suggests specific involvement of dopaminergic systems, although not necessarily identical sites, in mediating cocaine- and amphetamine-induced locomotor stimulation. This study examined the effects o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245649
更新日期:1991-01-01 00:00:00
abstract::We examined the effects on sucrose consumption of a dopamine (DA) D2/D3 antagonist (raclopride, 0-0.3 mg/kg), a serotonin 5-HT2/2c antagonist (ritanserin, 0-0.4 mg/kg), and raclopride (0.15 mg/kg) combined with ritanserin (0-0.4 mg/kg). Three different concentrations of sucrose solution (0.7%, 7.0% and 34%) were teste...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246286
更新日期:1996-01-01 00:00:00
abstract::The novel dopamine autoreceptor antagonists (-)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (-)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (-)-DS 121 produce...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246149
更新日期:1995-07-01 00:00:00
abstract::It has previously been shown that serotonergic [5-hydroxytryptamine (5-HT)] neurons of the median raphe nucleus (MR) are critically involved in the control of the hippocampal electroencephalogram (EEG). Activation of MR 5-HT neurons desynchronizes the hippocampal EEG, whereas inhibition of MR 5-HT activity produces hi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02311170
更新日期:1995-08-01 00:00:00
abstract:RATIONALE:Animal studies indicate that dopamine pathways in the ventral striatum code for the motivational salience of both rewarding and aversive stimuli, but evidence for this mechanism in humans is less established. We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of t...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2278-4
更新日期:2011-09-01 00:00:00
abstract::Neuroleptic-free schizophrenic patients received caerulein, a potent analogue of cholecystokinin octapeptide, in a fixed- and rising-dose schedule. In addition, neuroleptic-treated patients received a single dose of the peptide with a 4-week follow-up. No significant change in mental status was observed after any of t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00180843
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated. OBJECTIVES:We examined the ingestive behavioral effects of MTII at the microstructural level using two complementary approaches. METHODS...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1022-5
更新日期:2002-04-01 00:00:00
abstract::Benzodiazepines and other compounds which act at benzodiazepine binding sites have been shown previously to attenuate the acquisition of conditioned fear in rodents when administered before the acquisition session, an effect which may parallel the disruption of human memory produced by anxiolytics and sedatives. Such ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181243
更新日期:1986-01-01 00:00:00
abstract::The present study was undertaken to evaluate the effects of single and repeated doses of triazolam (1 mg/kg IP) and desipramine (DMI) (10 mg/kg IP) alone and in combination on certain pharmacologic responses and brain catecholamine levels in rats. The significant findings were: (1) triazolam and DMI given alone and in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427882
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Like other monoamine releasers such as D-amphetamine, chronic treatment with phenmetrazine can attenuate cocaine self-administration in monkeys. OBJECTIVES:The present studies extended this finding to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse. METHODS:In expe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3875-4
更新日期:2015-07-01 00:00:00
abstract:RATIONALE:The endogenous opioid system has been implicated in substance abuse and response to pharmacotherapies for nicotine and alcohol addiction. We examined (1) the association of the functional OPRM1 A118G variant with the relative reinforcing value of nicotine and (2) the main and interacting effects of the mu-opi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0504-2
更新日期:2006-10-01 00:00:00
abstract:RATIONALE:Although many studies have investigated the effects of gestational and lactational cocaine use on maternal behavior, few studies have examined the effects of prior adult cocaine use on maternal behavior. METHODS:In the current study, intraperitoneal cocaine or saline was administered to adult female rats for...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1777-z
更新日期:2010-03-01 00:00:00
abstract::The aim of the present study was to evaluate the effects of nicotinic acetylcholine receptor (nACh-R) agonists such as (-)-nicotine and related compounds on brain monoamine turnover. A single administration of (-)-nicotine (0.04, 0.2, 1.0, and 5.0 mg/kg SC) increased both noradrenaline (NA) and dopamine (DA) turnover ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050184
更新日期:1997-02-01 00:00:00
abstract:RATIONALE:So-called atypical antipsychotics (AAPs) are associated with varying levels of weight gain and associated metabolic disturbances, which in patients with serious mental illness (SMI) have been linked to non-compliance and poor functional outcomes. Mechanisms underlying AAP-induced metabolic abnormalities are o...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-016-4324-8
更新日期:2016-07-01 00:00:00
abstract::Two enantiomers (1S and 1R) of delta-3-tetrahydrocannabinol were assayed in man for psychoactivity. The 1S enantiomer had definite psychic actions, qualitatively similar to those of delta-1-tetrahydrocannabinol, but quantitatively less potent (1:3 to 1:6). Adding the two enantiomers together did not increase the effec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00176485
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Combining neuroleptics with 5-HT1A ligands is thought to improve the preclinical profile of neuroleptics and may be of interest in the development of new compounds that have greater therapeutic potential and/or are better tolerated. OBJECTIVE:To examine 1) the ability of 5-HT1A ligands to alter the effects o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050972
更新日期:1999-05-01 00:00:00
abstract:RATIONALE:Methylphenidate is a psychostimulant given for extended periods of time as a treatment of attention-deficit/hyperactivity disorder (ADHD). The long-term effects of the drug are not yet known, and it is speculated that repeated exposure may produce drug dependence. OBJECTIVE:To investigate the effects of repe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2564-1
更新日期:2012-05-01 00:00:00
abstract:RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3940-z
更新日期:2015-08-01 00:00:00
abstract:RATIONALE:Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. OBJECTIVE:To evaluate the hypothesis that neurodevelopmental deficits affect neurodegeneration occurring with schizophrenia, this study examined a novel animal model for schizophrenia-related ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2269-5
更新日期:2011-06-01 00:00:00
abstract::Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00555210
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND AND RATIONALE:Despite the popularity of polysubstance abuse among recreational methylendioxymethamphetamine (MDMA) users, relatively few controlled experimental studies have documented the neurobehavioral effects of MDMA in combination with other abused substances. OBJECTIVE:In this study, the combined acut...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1774-2
更新日期:2010-03-01 00:00:00
abstract::A novel form of experimentally-induced conflict behavior based on the conditioned suppression of drinking (CSD) is described and compared with two conventional animal models of human anxiety--a modified Geller-Seifter and an Estes-Skinner (Conditioned Emotional Response) procedure. The CSD procedure offered significan...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427112
更新日期:1981-01-01 00:00:00
abstract::In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431848
更新日期:1978-03-01 00:00:00
abstract:RATIONALE:Contemporary animal models of cocaine addiction focus on increasing the amount of drug consumption to produce addiction-like behavior. However, another critical factor is the temporal pattern of consumption, which in humans is characterized by intermittency, both within and between bouts of use. OBJECTIVE:To...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4393-8
更新日期:2016-10-01 00:00:00
abstract:RATIONALE:Some recent pharmacoepidemiological studies revealed an elevated risk of driving accidents after opioid analgesics uses. Among analgesics, codeine is often associated with paracetamol in numerous pharmaceutical specialties. OBJECTIVES:The objective of this study was to evaluate the dose-effect relationship o...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-013-3035-7
更新日期:2013-07-01 00:00:00
abstract:RATIONALE:The rapid membrane actions of neuroactive steroids, particularly via an enhancement of γ-aminobutyric acidA receptors (GABAARs), participate in the regulation of central nervous system excitability. Prior evidence suggests an inverse relationship between endogenous GABAergic neuroactive steroid levels and beh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3618-y
更新日期:2014-09-01 00:00:00