Abstract：
:Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the upper and low lips using TV images. The human observer data indicated that during HAL administration the total duration of OMs was initially decreased, gradually returned to levels slightly above controls, and then increased substantially upon drug withdrawal. The computer records confirmed these findings and further indicated that after prolonged HAL administration a syndrome developed in which large-amplitude OMs remained suppressed but OMs of the smallest detectable amplitudes increased. Upon drug withdrawal, these small OMs increased in amplitude and rhythmicity, developing into repetitive tremors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ellison G,See R,Levin E,Kinney Jdoi
10.1007/BF00215492subject
Has Abstractpub_date
1987-01-01 00:00:00pages
122-6issue
1eissn
0033-3158issn
1432-2072journal_volume
92pub_type
杂志文章abstract：:The mesolimbic dopamine (DA) system has been implicated in conditioned reward (CR), locomotor sensitization, and the reinforcing properties of psychomotor stimulants. Stimuli with formerly motivationally neutral properties that gain incentive properties by their predictive association with primary reinforcers are term...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050859
更新日期：1999-02-01 00:00:00
abstract：:ApolipoproteinE (ApoE) genotype has recently been identified as a major risk factor for Alzheimer's disease (AD) but the mechanism(s) by which ApoE isoforms influence this disease remain unclear. Recent studies suggest that mice deficient in ApoE may exhibit impaired central cholinergic function. Since this neurotrans...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050329
更新日期：1997-07-01 00:00:00
abstract：:The purpose of this study was to investigate the developmental differences in seizure susceptibility in mice and the roles of the histaminergic neuron system in inhibition of convulsions in development. First, we studied developmental differences in electrically-induced seizures. Since the 14-day-old mice showed a dif...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244911
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexive responses, and these systems are activated by aversive stimuli. OBJECTIVES:The present experiments evaluated the influence of opioid re...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051101
更新日期：1999-09-01 00:00:00
abstract：:Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245521
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:Traditional remedies prepared from Ptychopetalum olacoides (PO) are used throughout the Amazon to alleviate age-related conditions. These formulas are mainly used by elders, and alleged effects may be related to the anticholinesterase properties identified in a standardized ethanol extract of this species [P....
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1272-y
更新日期：2009-01-01 00:00:00
abstract：RATIONALE:Longitudinal, population-based studies can better assess the relationship of ecstasy use with depression. OBJECTIVES:We examined whether change in ecstasy use was associated with change in depressive symptoms/probable depression over a 4-year period, among a large Australian sample. METHODS:The Personality ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3132-7
更新日期：2013-10-01 00:00:00
abstract：RATIONALE:Preclinical evidence suggests that non-cannabinoid neurotransmitter systems are involved in the behavioral and physiological effects of cannabinoids, but relatively little research has been conducted in humans. OBJECTIVES:The aims of this study were to assess whether oral Delta(9)-tetrahydrocannabinol (Delta...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1393-3
更新日期：2009-04-01 00:00:00
abstract：:Nine human subjects were exposed to a multiple fixed-ratio (FR) differential-reinforcement-of-low-rate (DRL) schedule of monetary reinforcement. Presses on a manipulandum requiring relatively high force were occasionally followed by an increased money total displayed on a computer screen. Subjects were exposed to the ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00177913
更新日期：1987-01-01 00:00:00
abstract：RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3829-2
更新日期：2015-06-01 00:00:00
abstract：RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000630
更新日期：2001-03-01 00:00:00
abstract：RATIONALE AND OBJECTIVE:Because of the important role of dopamine in neurotransmission, it would be useful to be able to image brain dopamine receptor-mediated signal transduction in animals and humans. Administering the D1-D2 receptor agonist apomorphine may allow us to do this, as the D2-like receptor is reported to ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1073-3
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Several different animal models are currently used to research the neurodegenerative movement disorder Parkinson's disease (PD). RESULTS:Models based on the genetic deficits associated with a small percentage of sufferers demonstrate the pathological accumulation of alpha-synuclein characteristic of the dis...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-007-0931-8
更新日期：2008-08-01 00:00:00
abstract：RATIONALE:Obsessive-compulsive disorder (OCD) gradually emerges and reaches clinical significance during early adulthood. Whether a predisposition for OCD manifests as binge eating disorder earlier during adolescence is proposed. OBJECTIVES:To further characterize how OCD-like behaviors increase across maturation and ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3967-1
更新日期：2015-09-01 00:00:00
abstract：RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-2060-y
更新日期：2005-05-01 00:00:00
abstract：RATIONALE:Impulsivity has been strongly linked to addictive behaviors, but can be operationalized in a number of ways that vary considerably in overlap, suggesting multidimensionality. OBJECTIVE:This study tested the hypothesis that the latent structure among multiple measures of impulsivity would reflect the followin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4372-0
更新日期：2016-09-01 00:00:00
abstract：:The effects of acutely or chronically administered carbamazepine were studied in rats submitted to the modified Geller-Seifter conflict test. Diazepam was used as a standard anxiolytic. The results showed an increase in punished response after carbamazepine, as observed with diazepam, leading to the suggestion of an a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244411
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Dronabinol (Δ(9)tetrahydrocannabinol) is approved for HIV-related anorexia, yet, little is known about its effects in HIV-positive marijuana smokers. HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects. OBJECTIVES:Employing a within-subjects, double-...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1995-4
更新日期：2010-12-01 00:00:00
abstract：AIM:Excess consumption of alcohol leads to impaired cognition and decision making; hence, alcohol-containing products and advertising contain warning messages about the adverse effects of excess drinking. However, there is a need to understand how alcohol influences the processing of advisory messages. METHOD:The curr...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-009-1762-6
更新日期：2010-03-01 00:00:00
abstract：RATIONALE:Cognitive rehabilitation is now recognized as an important tool in the treatment of schizophrenia, and findings in this area are emerging rapidly. There is a need for a systematic review of the effects of the different training programs. OBJECTIVES:To review quantitatively the controlled studies on cognitive...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1326-5
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:New psychoactive substances (NPS) are chemical analogues designed to mimic the effects of various classic recreational drugs of abuse including MDMA, LSD, and cannabis. NPS use is associated with concern about the acute and longer-term effects particular substances might have, with abuse and addiction as pot...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-018-4931-7
更新日期：2018-08-01 00:00:00
abstract：:Serotonergic mechanisms have been implicated in the pathophysiology of depression and in the neuropharmacology of antidepressant treatment. One measure of central serotonergic function is the prolactin (PRL) response to IV L-tryptophan (L-TRP). We used the L-TRP test to assess the role of serotonin in the mechanism of...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245291
更新日期：1992-01-01 00:00:00
abstract：:In the context of Pavlovian conditioning, two types of behaviour may emerge within the population (Flagel et al. Nature, 469(7328): 53-57, 2011). Animals may choose to engage either with the conditioned stimulus (CS), a behaviour known as sign-tracking (ST) which is sensitive to dopamine inhibition for its acquisition...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05323-y
更新日期：2019-08-01 00:00:00
abstract：RATIONALE:The present series of experiments was conducted in order to assess the nature of dopaminergic modulation of the acoustic startle response using agonists and antagonists specific for dopamine D1 and D2 receptors. OBJECTIVES:The objective of the present study was to demonstrate an enhancement of the acoustic s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051020
更新日期：1999-06-01 00:00:00
abstract：RATIONALE:Brain waves reflect collective behavior of neurons and provide insight into distributed network processing. Frontal and hippocampal theta oscillations (4-7 Hz) were linked to cognitive tasks and animal studies have suggested an involvement of glutamatergic neurotransmission in integrative frontal-hippocampal ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0397-0
更新日期：2006-07-01 00:00:00
abstract：:The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control d...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428551
更新日期：1984-01-01 00:00:00
abstract：:The effects of bilateral nucleus accumbens microinjections of d-ala-met-enkephalinamide (DALA) were assessed in behavioral activation and lateral hypothalamic self-stimulation (LHSS) rate-frequency curve-shift paradigms in normal and accumbens 6-OHDA (4.0 micrograms) treated rats. Microinjections of DALA (2.5 microgra...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244999
更新日期：1994-05-01 00:00:00
abstract：RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0805-0
更新日期：2007-09-01 00:00:00
abstract：RATIONALE:A sensitized dopamine system may be linked to the genesis of psychotic symptoms in schizophrenia. Following withdrawal from amphetamine exposures, psychotic-like traits have been robustly demonstrated, but the presence of cognitive/mnemonic deficits remains uncertain. METHODS:Adult male Lewis and Fischer rat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1514-7
更新日期：2009-11-01 00:00:00
abstract：RATIONALE:The five-choice serial reaction time task (5-CSRTT) is regularly used to study attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial interval (ITI), a light appears in one of five holes. Responding in the lit vs. unlit hole reflects attention (accuracy), while respondi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4389-4
更新日期：2016-10-01 00:00:00
