Abstract:
:Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the upper and low lips using TV images. The human observer data indicated that during HAL administration the total duration of OMs was initially decreased, gradually returned to levels slightly above controls, and then increased substantially upon drug withdrawal. The computer records confirmed these findings and further indicated that after prolonged HAL administration a syndrome developed in which large-amplitude OMs remained suppressed but OMs of the smallest detectable amplitudes increased. Upon drug withdrawal, these small OMs increased in amplitude and rhythmicity, developing into repetitive tremors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ellison G,See R,Levin E,Kinney Jdoi
10.1007/BF00215492subject
Has Abstractpub_date
1987-01-01 00:00:00pages
122-6issue
1eissn
0033-3158issn
1432-2072journal_volume
92pub_type
杂志文章abstract::The mesolimbic dopamine (DA) system has been implicated in conditioned reward (CR), locomotor sensitization, and the reinforcing properties of psychomotor stimulants. Stimuli with formerly motivationally neutral properties that gain incentive properties by their predictive association with primary reinforcers are term...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:2016-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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更新日期:2010-12-01 00:00:00
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更新日期:1992-01-01 00:00:00
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更新日期:2019-08-01 00:00:00
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doi:10.1007/s002130051020
更新日期:1999-06-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/s00213-006-0397-0
更新日期:2006-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428551
更新日期:1984-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244999
更新日期:1994-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0805-0
更新日期:2007-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1514-7
更新日期:2009-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4389-4
更新日期:2016-10-01 00:00:00