Effects of physostigmine, scopolamine, and mecamylamine on the sleeping time induced by ketamine in the rat.

abstract：RATIONALE:Tolerance to delay of gratification, taken to reflect impulsiveness, has been proposed to be under the preferential control of central serotonin (5-HT) processes. OBJECTIVE:The present study further examined the effects of drugs which directly or indirectly alter 5-HT transmission, on behaviour controlled by...

journal_title：Psychopharmacology

authors： Bizot J,Le Bihan C,Puech AJ,Hamon M,Thiébot M

更新日期：1999-10-01 00:00:00

abstract：:The fatty acid specificity of the depressant actions associated with prostaglandin (PG) administration was studied in mice. Administration of PG-E2 (0.4 and 1.0 mg/kg) or PG-D2 (0.4 and 4 mg/kg) significantly potentiated pentobarbital sleeping time. Arachidonic acid (3.3 mg/kg) administration also significantly potent...

journal_title：Psychopharmacology

authors： Holingsworth EB,Patrick GA

更新日期：1984-01-01 00:00:00

abstract：:Depression in children is currently an area of considerable controversy, as is the use of potent psychopharmacologic agents in children. Since EEG sleep techniques have proven to be useful in understanding the mechanisms of depression in adults and in predicting their response to antidepressants, a pilot study employi...

journal_title：Psychopharmacology

authors： Kupfer DJ,Coble P,Kane J,Petti T,Conners CK

更新日期：1979-01-31 00:00:00

abstract：:Nefiracetam is undergoing preclinical and clinical tests as a cognition-enhancing drug in Alzheimer's disease (AD). Nicotinic cholinergic receptors are lost in AD, and nicotinic as well as muscarinic cholinergic receptors are involved in the modulation of eyeblink conditioning. Experiments were carried out using young...

journal_title：Psychopharmacology

authors： Woodruff-Pak DS,Hinchliffe RM

更新日期：1997-05-01 00:00:00

abstract：:We are performing a double-blind trial with inward psychiatric patients. The indication for our psychotropic or psychotherapeutic intervention is mainly severe depression (= major depressive disorders DSM III). For a 3-week trial course trazodone (400 mg daily), amitriptyline (150 mg/die) or placebo capsules were give...

journal_title：Psychopharmacology

authors： Klieser E,Lehmann E

更新日期：1988-01-01 00:00:00

abstract：:The administration of trycyclic antidepressants followed by reserpine-like drugs elicits a pattern of stereotyped locomotor activity. Using desmethylimipramine (DMI) followed by tetrabenazine (TBZ), activity could be reliably elicited only in young rats, and only by using very high doses of TBZ. The latency of onset o...

journal_title：Psychopharmacology

authors： Willner P,Clark D

更新日期：1978-06-15 00:00:00

abstract：:Dopaminergic behavioral supersensitivity may be induced by chronic treatment with either dopaminergic agonists or antagonists. We demonstrate that the development of agonist-induced supersensitivity is resistant to chronic lithium exposure. Furthermore, chronic lithium alone enhances the stereotypic response to acute ...

journal_title：Psychopharmacology

authors： Rubin EH,Wooten GF

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Performance on progressive ratio schedules has been proposed as a means of assessing the effects of drugs on the value or "efficacy" of reinforcers. A mathematical model affords a basis for quantifying the effects of drugs on progressive ratio schedule performance. According to this model, the relation betwee...

journal_title：Psychopharmacology

authors： Zhang Z,Rickard JF,Asgari K,Body S,Bradshaw CM,Szabadi E

更新日期：2005-05-01 00:00:00

abstract：:The effects of naloxone on diazepam-induced release of behavior in aversive situations were investigated in rats. Naloxone (0.5 and 1 mg/kg-1) suppressed diazepam-induced eating in an unfamiliar situation and reduced (1 mg/kg-1) spontaneous food intake. Naloxone (1 mg/kg-1) canceled the increased lever pressing produc...

journal_title：Psychopharmacology

authors： Soubrié P,Jobert A,Thiebot MH

更新日期：1980-01-01 00:00:00

abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...

journal_title：Psychopharmacology

authors： Monteleone P,Iovino M,Orio F,Steardo L

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects. OBJECTIVE:To ascertain effects of flumazenil in the social conflict te...

journal_title：Psychopharmacology

authors： Uhlírová L,Sustková-Fiserová M,Krsiak M

更新日期：2004-01-01 00:00:00

abstract：:The number of nerve cells in two different areas of the corpus striatum (i.e., ventrolateral and dorsomedial) was estimated in rat brain after long-term (36 weeks) treatment with the neuroleptic flupenthixol. Nine rats were given weekly injections of 4 mg/kg flupenthixol dissolved in Viscoleo i.m., and seven rats rece...

journal_title：Psychopharmacology

authors： Nielsen EB,Lyon M

更新日期：1978-09-15 00:00:00

abstract：RATIONALE:Consistent sex differences are observed in human drug addiction, with females often exceeding males on drug intake. However, there is still a need for animal models for some aspects of addiction such as acquisition of drug self-administration and the subsequent development of drug-seeking. OBJECTIVES:The pre...

journal_title：Psychopharmacology

authors： Swalve N,Smethells JR,Carroll ME

更新日期：2016-03-01 00:00:00

abstract：:The effects of meperidine on operant behavioral thermoregulation were investigated using a convective thermal controller and mice trained to alternate at will the thermal-drive condition, changing it from an air flow of 15 degrees C to one of 45 degrees C, and vice versa. Administration of 15 mg/kg meperidine resulted...

journal_title：Psychopharmacology

authors： Gessner PK,Clarke CC

更新日期：1979-09-01 00:00:00

abstract：RATIONALE:In cell culture systems, agonists can promote the phosphorylation and internalization of receptors coupled to G proteins (GPCR), leading to their desensitization. However, in the CNS opioid agonists promote a profound desensitization of their analgesic effects without diminishing the presence of their recepto...

journal_title：Psychopharmacology

authors： Garzón J,Rodríguez-Muñoz M,de la Torre-Madrid E,Sánchez-Blázquez P

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Morphine and buprenorphine have analgesic and anxiolytic-like properties. While their analgesic effects have been well characterized, their anxiolytic-like properties have not. OBJECTIVES:Effects of acute morphine and buprenorphine on the expression of acoustic fear-potentiated startle (FPS) and naloxone pre...

journal_title：Psychopharmacology

authors： Glover EM,Davis M

更新日期：2008-06-01 00:00:00

abstract：RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...

journal_title：Psychopharmacology

authors： Halberstadt AL,Brandt SD,Walther D,Baumann MH

更新日期：2019-03-01 00:00:00

abstract：:Male Sprague-Dawley rats were evaluated between ages 18 and 825 days for responses to doses of haloperidol (0 and 0.05-10 mg/kg, IP). Catalepsy, ptosis, and inhibition of general motor activity showed steady decreases in sensitivity to the drug with age during the first 1.5 years of maturation, while rats older than 1...

journal_title：Psychopharmacology

authors： Campbell A,Baldessarini RJ

更新日期：1981-01-01 00:00:00

abstract：:The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of...

journal_title：Psychopharmacology

authors： Rochat C,Cervo L,Romandini S,Samanin R

更新日期：1982-01-01 00:00:00

abstract：:In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...

journal_title：Psychopharmacology

authors： Katz RJ,Liebler L

更新日期：1978-03-01 00:00:00

abstract：:There is increasing interest in the potential functional role of the octapeptide angiotensin II (AII) in psychiatric and cognitive disorders. The novel angiotensin II (AII) receptor antagonists, losartan and PD123177, selective for the AT1 and AT2 receptor subtypes respectively, constitute important pharmacological to...

journal_title：Psychopharmacology

authors： Shepherd J,Bill DJ,Dourish CT,Grewal SS,McLenachan A,Stanhope KJ

更新日期：1996-08-01 00:00:00

abstract：RATIONALE:Neurobiological models of addiction suggest that abnormalities of brain reward circuitry distort salience attribution and inhibitory control processes, which in turn contribute to high relapse rates. OBJECTIVES:The aim of this study is to determine whether impairments of salience attribution and inhibitory c...

journal_title：Psychopharmacology

authors： Powell J,Dawkins L,West R,Powell J,Pickering A

更新日期：2010-12-01 00:00:00

abstract：:The effects of benztropine, scopolamine, atropine, methylatropine, amitriptyline, phencyclidine, and meperidine were determined alone and in conjunction with a behaviorally suppressing dose (0.05 mg/kg IM) of oxotremorine in pigeons responding under a multiple fixed-ratio 30 fixed-interval 5-min schedule of grain pres...

journal_title：Psychopharmacology

authors： Leander JD

更新日期：1981-01-01 00:00:00

abstract：:NCQ 298 ((S)-3-iodo-N-[(l-ethyl-2-pyrrolidinyl)methyl]-5,6- dimethoxysalicylamide) has an iodine substituent. We have labelled NCQ 298 with 123I and 125I, and used the radioligands as tracers in receptor studies in vitro, in vivo in autoradiography and in SPECT studies on Cynomolgus monkeys. [125I]NCQ 298 bound in vit...

journal_title：Psychopharmacology

authors： Hall H,Högberg T,Halldin C,Köhler C,Ström P,Ross SB,Larsson SA,Farde L

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...

journal_title：Psychopharmacology

authors： Jacques A,Chaaya N,Hettiarachchi C,Carmody ML,Beecher K,Belmer A,Chehrehasa F,Bartlett S,Battle AR,Johnson LR

更新日期：2019-01-01 00:00:00

abstract：:Paradoxical sleep (PS) in the rat, cat and mouse is preceded and sometimes followed by a short-lasting intermediate stage (IS) characterized by high amplitude cortical spindles and low frequency theta rhythm. This stage, which is mimicked by an intercollicular transection, is massively extended at the expense of PS by...

journal_title：Psychopharmacology

authors： Arnaud C,Gauthier P,Gottesmann C

更新日期：1994-11-01 00:00:00

abstract：:Dose-related effects of ethanol (placebo, 0.30, and 0.60 g/kg) on behavioral and event-related brain potential (ERP) indices of involuntary attention shifting of audition were investigated. ERPs were recorded from 11 healthy social drinkers during a forced-choice reaction-time (RT) task. Subjects were presented with 1...

journal_title：Psychopharmacology

authors： Jääskeläinen IP,Schröger E,Näätänen R

更新日期：1999-01-01 00:00:00

abstract：:The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring System. In the cocain...

journal_title：Psychopharmacology

authors： Rocha BA,Odom LA,Barron BA,Ator R,Wild SA,Forster MJ

更新日期：1998-07-01 00:00:00

abstract：:The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...

journal_title：Psychopharmacology

authors： Andrée B,Thorberg SO,Halldin C,Farde L

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:Interrelationships between the discriminative stimulus and reinforcing properties of psychoactive drugs and the way in which they may interact to control drug intake are unclear. Studies have shown that drug history can influence the expression of drug-produced behavioral effects. OBJECTIVE:The present study...

journal_title：Psychopharmacology

authors： Childs E,Shoaib M,Stolerman IP

更新日期：2006-06-01 00:00:00