Abstract：
:Male Sprague-Dawley rats were evaluated between ages 18 and 825 days for responses to doses of haloperidol (0 and 0.05-10 mg/kg, IP). Catalepsy, ptosis, and inhibition of general motor activity showed steady decreases in sensitivity to the drug with age during the first 1.5 years of maturation, while rats older than 1.5 years had strikingly increased sensitivity to the activity-inhibiting and cataleptic effects of the drug. The efficacy of haloperidol on all tests in 110-day old rats was indistinguishable whether food was available continuously, or restricted to reduce body weight by 55%, indicating that the effects of maturation are due to aging and not to increasing body weight. The effects may be due to altered drug metabolism or altered sensitivity of the central nervous system to neuroleptic agents. Clinical impressions too, indicate that immature and elderly patients are more sensitive to these and other psychotropic drugs than are young adults.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Campbell A,Baldessarini RJdoi
10.1007/BF00422406subject
Has Abstractpub_date
1981-01-01 00:00:00pages
219-22issue
3eissn
0033-3158issn
1432-2072journal_volume
73pub_type
杂志文章abstract：:Following the stereotaxic implantation of chronic cannulae for intracerebroventricular (ICV) infusion, rats were given an alcohol preference test to establish their preferred concentration in comparison with water. After alcohol was removed, 15 mg/kg cyanamide was then injected subcutaneously for 4 days in order to ma...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00444688
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:The α7 nicotinic acetylcholine receptor (nAChR) has been implicated as a target in modulating nicotine reward. However, the effect of pharmacological agents that have been shown to alter the channel properties of the α7 nAChR is not well understood in nicotine reward. OBJECTIVES:This study aimed to investiga...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05331-y
更新日期：2019-12-01 00:00:00
abstract：INTRODUCTION:The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state. RESULTS:In opioid receptor binding and G protein activation, we confirmed that M1, but not tramadol, showed mu-opioid receptor (MO...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1180-1
更新日期：2008-10-01 00:00:00
abstract：RATIONAL:It has been suggested that phosphodiesterase 5 inhibitors such as sildenafil may be effective in the treatment of negative symptoms of schizophrenia. OBJECTIVE:This study was designed to investigate the effect of sildenafil added to risperidone as augmentation therapy in patients with chronic schizophrenia an...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-010-2044-z
更新日期：2011-02-01 00:00:00
abstract：:It has been shown that pretreatment with dopamine (DA) receptor blockers disrupts the effect of intravenously (IV) and intracerebrally (ICV), but not intraperitoneally (IP) administered cocaine on place preference conditioning (PPC). The present study was undertaken to further evaluate possible differences between IV ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00735892
更新日期：1988-01-01 00:00:00
abstract：:Relationships between aging effects on apomorphine (AP)-induced stereotypy and AP concentrations in plasma and brain were studied in rats. In two separate behavioral studies, four groups of male Wistar rats (3, 6, 20, and 43 weeks of age) and two groups of female Wistar rats (5 and 35 weeks of age) were used, respecti...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00430756
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Hypersignaling of corticotropin releasing factor (CRF) has been implicated in stress disorders; however, many of its downstream mechanisms of action remain unclear. In vitro, CRF1 receptor activation initiates multiple cell signaling cascades, including protein kinase A (PKA), protein kinase C (PKC), and mito...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3114-9
更新日期：2013-10-01 00:00:00
abstract：:Monoamine oxidase inhibitors (MAOIs) are widely accepted as effective antidepressants. Unfortunately their use has been limited by their capacity to potentiate dietary tyramine (the so called "cheese effect") and their interaction with other drugs. The latter poses a particular problem for patients undergoing anaesthe...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02246234
更新日期：1992-01-01 00:00:00
abstract：:Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432549
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Zotepine is an antipsychotic drug with proven efficacy for treatment of acute episodes of schizophrenia. Antipsychotic drugs also require to be effective in prevention of recurrence. OBJECTIVE:This trial was designed to compare the effects of zotepine and placebo in the prevention of recurrence of acute epis...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130000452
更新日期：2000-06-01 00:00:00
abstract：:BALB/cJ, DBA/2J, and C57BL/6J mice were injected with caffeine and tested, in the five choice Yerkes-Thompson Bryant-Bovt Nitti apparatus for patterns discrimination, in two sets of experiments. In the first the patterns were opposite oriented oblique bars, in the second U-shaped figures, one opened toward the right, ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431632
更新日期：1977-03-16 00:00:00
abstract：RATIONALE:The majority of volumetric magnetic resonance imaging (MRI) studies of the hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal volume between patients and healthy controls. Significant variability, however, exists in the medication status of patients included in these studies...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0906-9
更新日期：2007-12-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-009-1585-5
更新日期：2009-09-01 00:00:00
abstract：RATIONALE:Therapeutic efficacy of antidepressant drugs appears to be related to their ability in producing neuroadaptive changes that restore normal brain function. Activity-regulated cytoskeletal associated protein (Arc) is an effector immediate early gene that plays a fundamental role in activity-dependent neural pla...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1276-7
更新日期：2008-12-01 00:00:00
abstract：RATIONALE:Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in behaviours related to salient, reward-paired cues. OBJECTIVES:Here,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4627-4
更新日期：2017-08-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2803-0
更新日期：2013-01-01 00:00:00
abstract：RATIONALE:The indirect dopamine agonist methylphenidate remediates cognitive deficits in psychopathology, but the individual characteristics that determine its effects on the brain are not known. OBJECTIVES:We aimed to determine whether targeted dopaminergically modulated traits and individual differences could predic...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-016-4307-9
更新日期：2016-07-01 00:00:00
abstract：:Rats were trained to self-stimulate by interrupting a photobeam and brain stimulation was maintained for as long as the beam of light was broken. d-Amphetamine sulphate was then administered and response rate and total duration of stimulation were recorded. Both response rate and total duration were elevated by 1.0, 2...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00496071
更新日期：1979-08-08 00:00:00
abstract：:Development of tolerance to neuroleptic compounds tested in the conditional avoidance model was investigated. Since tolerance may manifest itself by a diminished potency and/or a shortened duration of effect, the complete time course of effect was registered in these experiments. Rats were pretreated approximately 2 w...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426314
更新日期：1976-12-21 00:00:00
abstract：RATIONALE:Although the effects of D: -cycloserine (DCS) and valproic acid (VPA) on the facilitation of the extinction of fear-conditioned memory have been elucidated in animals, these effects have not been clearly confirmed in humans. OBJECTIVE:This study aimed to determine the effect of DCS (100 mg) and VPA (400 mg) ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2353-x
更新日期：2011-12-01 00:00:00
abstract：RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1100-4
更新日期：2008-05-01 00:00:00
abstract：RATIONALE:Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. OBJECTIVE:The present study sought to characterize the effects of several dopamine D(4) agonists and antagonists on the disc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1238-0
更新日期：2009-04-01 00:00:00
abstract：RATIONALE:A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother. OBJECTIVE:The objective of this study was to develop a model of clinically relevant prenatal exposure to an antidepressant and stress during pregnancy to evaluate...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3030-z
更新日期：2013-07-01 00:00:00
abstract：RATIONALE:It has been proposed that brain aldehyde dehydrogenase (ALDH) plays a role in the modulation of some psychopharmacological effects of ethanol. Diethyldithiocarbamate (DDTC), an ALDH inhibitor, elevates blood acetaldehyde levels in the presence of ethanol. Concurrent administration with 4-methylpyrazole (4-MP)...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-001-0991-0
更新日期：2002-04-01 00:00:00
abstract：:The effects of bromocriptine, lisuride and apomorphine on specific binding of 3H-spiroperidol to homogenates of rat caudate nucleus were studied. (+)-Butaclamol was used to define specific binding. Bromocriptine and lisuride inhibited binding markedly, in vitro and also 30 min after in vivo injection. Bromocriptine co...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432172
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2527-6
更新日期：2012-04-01 00:00:00
abstract：RATIONALE:Recent studies have shown that pharmacological inhibition of the 12-lipoxygenase pathway selectively blocks opioid inhibition of GABAergic synaptic currents. A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, al...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1526-7
更新日期：2003-11-01 00:00:00
abstract：RATIONALE:It has been reported that in panic disorder (PD), tryptophan depletion enhances the vulnerability to experimentally induced panic, while the administration of serotonin precursors blunts the response to challenges. OBJECTIVES:Using a high-dose carbon dioxide (CO(2)) challenge, we aimed to investigate the eff...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2177-8
更新日期：2011-06-01 00:00:00
abstract：:The rabbit classical eyeblink conditioning paradigm was used to assess the effects of haloperidol on hippocampal function. Haloperidol disrupted hippocampal activity and conditioned responses (CRs) at low but not high conditioned stimulus (CS) intensities. The observed relationship of hippocampal activity and the CR s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050237
更新日期：1997-04-01 00:00:00
abstract：:The 12-h brain lithium concentration was measured by lithium-7 magnetic resonance spectroscopy in ten manic-depressive patients receiving daily or alternate-day lithium carbonate treatment. The median dose of lithium carbonate was 800 mg in the daily treatment group and 1200 mg in the alternate-day group. Median 12-h ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246668
更新日期：1996-04-01 00:00:00
