当前位置： SCI文献检索 > PSYCHOPHARMACOLOGY期刊下所有文献 > Expression of amphetamine sensitization is associated with recruitment of a reactive neuronal population in the nucleus accumbens core.

Expression of amphetamine sensitization is associated with recruitment of a reactive neuronal population in the nucleus accumbens core.

Abstract：

RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striatal activation patterns similar to acute treatment with a high dose of amphetamine. OBJECTIVES:To extend previous findings of striatal hypersensitivity with behavioral observations and with cellular activity in the nucleus accumbens and prefrontal cortex in sensitized animals. MATERIALS AND METHODS:Rats treated acutely with 0, 1, 2.5, or 5 mg/kg i.p. amphetamine and sensitized rats challenged with 1 mg/kg i.p. amphetamine were scored for stereotypy, rearing, and grooming, and locomotor activity recorded. c-fos positive nuclei were quantified in the nucleus accumbens and prefrontal cortex after expression of sensitization with 1 mg/kg i.p. amphetamine. RESULTS:Intense stereotypy was seen in animals treated acutely with 5 mg/kg amphetamine, but not in the sensitized group treated with 1 mg/kg amphetamine. The c-fos response to amphetamine in the accumbens core was augmented in amphetamine-pretreated animals with a shift in the distribution of optical density, while no effect of sensitization was seen in the nucleus accumbens shell or prefrontal cortex. CONCLUSIONS:A lack of stereotypy in the sensitized group indicates a dissociation of behavioral responses to amphetamine and striatal immediate-early gene activation patterns. The increase in c-fos positive nuclei and shift in the distribution of optical density observed in the nucleus accumbens core suggests recruitment of a new population of neurons during expression of sensitization.

journal_name

Psychopharmacology (Berl)

journal_title

Psychopharmacology

authors

Nordquist RE,Vanderschuren LJ,Jonker AJ,Bergsma M,de Vries TJ,Pennartz CM,Voorn P

doi

10.1007/s00213-008-1100-4

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

113-26

issue

eissn

0033-3158

issn

1432-2072

journal_volume

198

pub_type

杂志文章

在线工具

Expression of amphetamine sensitization is associated with recruitment of a reactive neuronal population in the nucleus accumbens core.