Abstract:
:Adult rats that were gestationally exposed to cocaine and control offspring were examined for their sensitivity to challenge doses of cocaine. Offspring were derived from Sprague-Dawley dams that had received subcutaneous injections of 40 mg/kg per 3 cc cocaine hydrochloride daily on gestational days 8-20, pair-fed dams that were injected with saline, and nontreated control dams. In order to investigate the sensitivity to challenge doses of cocaine, offspring were assessed in adulthood for locomotor activity, cocaine drug discrimination, and the time course of cocaine in brain tissue following acute cocaine challenge. Adult offspring prenatally exposed to cocaine were observed to exhibit a reduced sensitivity to the discriminative stimulus effects of cocaine as evidenced by a significant shift to the right in the dose-response curve of cocaine discrimination. No prenatal treatment effects were observed in terms of the temporal patterns of cocaine discrimination or with regard to brain levels of cocaine. In addition, baseline locomotor activity and locomotor responses to challenge doses of cocaine were comparable across the prenatal treatment groups. Thus, prenatal cocaine exposure reduced sensitivity of offspring to the discriminative stimulus properties of cocaine without altering either the distribution of cocaine to the brain or the sensitivity of the offspring to the locomotor stimulant effects of cocaine.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Heyser CJ,Rajachandran L,Spear NE,Spear LPdoi
10.1007/BF02244870subject
Has Abstractpub_date
1994-09-01 00:00:00pages
45-55issue
1eissn
0033-3158issn
1432-2072journal_volume
116pub_type
杂志文章abstract:RATIONALE:Nitric oxide (NO) is a messenger synthesized in both the neuronal and glial populations by nitric oxide synthase type 1 (NOS1). Nicotine regulates NO production in a sex-dependent manner, both molecules being involved in motor function. OBJECTIVE:The present study evaluates sex differences in motor coordinat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3284-5
更新日期:2014-02-01 00:00:00
abstract::Three-hour sessions of differential reinforcement of low-rate behavior (DRL 45-s) in rats were used to investigate alprazolam, caffeine, and their interactions at the onset, peak and disappearance of serum alprazolam, while caffeine level remained constant. The dose-response curve (DRC) method of Pöch permitted an ext...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246346
更新日期:1996-07-01 00:00:00
abstract:RATIONALE:Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear. OBJECTIVE:The present study used pharmacological, event-related fMRI to test the hypothesis that striatal dopamine is important for t...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-009-1634-0
更新日期:2009-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05415-9
更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-020-05522-y
更新日期:2020-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00571418
更新日期:1978-01-31 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1145-8
更新日期:2002-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246552
更新日期:1995-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3573-7
更新日期:2014-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246164
更新日期:1995-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051083
更新日期:1999-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000468
更新日期:2000-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246978
更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433058
更新日期:1980-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1973-x
更新日期:2010-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427952
更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100732
更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-010-1947-z
更新日期:2010-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429660
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-010-1913-9
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130000452
更新日期:2000-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05532-w
更新日期:2020-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130000549
更新日期:2000-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02439598
更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-002-1169-0
更新日期:2002-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3654-7
更新日期:2015-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-010-2000-y
更新日期:2011-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3136-3
更新日期:2013-11-01 00:00:00
abstract:RATIONALE:We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome. OBJECTIVES:This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cess...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-017-4580-2
更新日期:2017-06-01 00:00:00