Sex-influence of nicotine and nitric oxide on motor coordination and anxiety-related neurophysiological responses.

abstract：RATIONALE:The noradrenergic and dopaminergic systems are targets for antidepressants and are stimulated by serotonergic antidepressant drugs. The COMT enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Clinical studies on the effect of rs4680 on antidep...

journal_title：Psychopharmacology

authors： Benedetti F,Colombo C,Pirovano A,Marino E,Smeraldi E

更新日期：2009-03-01 00:00:00

abstract：:Neuroleptic-free schizophrenic patients received caerulein, a potent analogue of cholecystokinin octapeptide, in a fixed- and rising-dose schedule. In addition, neuroleptic-treated patients received a single dose of the peptide with a 4-week follow-up. No significant change in mental status was observed after any of t...

journal_title：Psychopharmacology

authors： Tamminga CA,Littman RL,Alphs LD,Chase TN,Thaker GK,Wagman AM

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Individual differences in the rate of nicotine metabolism (RNM) could be related to dependence and success in stopping smoking. A range of studies have examined RNM measured by the ratio of trans-3'-hydroxycotinine and cotinine in body fluids (the ratio). A systematic review of this literature is needed to dr...

journal_title：Psychopharmacology

authors： West O,Hajek P,McRobbie H

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...

journal_title：Psychopharmacology

authors： Russig H,Murphy CA,Feldon J

更新日期：2003-09-01 00:00:00

abstract：RATIONALE:Effort-related motivational symptoms such as anergia and fatigue are common in patients with depression and other disorders. Research implicates pro-inflammatory cytokines in depression, and administration of cytokines can induce effort-related motivational symptoms in humans. OBJECTIVES:The present experime...

journal_title：Psychopharmacology

authors： Nunes EJ,Randall PA,Estrada A,Epling B,Hart EE,Lee CA,Baqi Y,Müller CE,Correa M,Salamone JD

更新日期：2014-02-01 00:00:00

abstract：RATIONALE:Noncontingent administration of amphetamine into the ventral striatum or systemic nicotine increases responses rewarded by inconsequential visual stimuli. When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABA(B) receptor agonis...

journal_title：Psychopharmacology

authors： Vollrath-Smith FR,Shin R,Ikemoto S

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differenti...

journal_title：Psychopharmacology

authors： Arkell TR,Lintzeris N,Kevin RC,Ramaekers JG,Vandrey R,Irwin C,Haber PS,McGregor IS

更新日期：2019-09-01 00:00:00

abstract：:Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of ...

journal_title：Psychopharmacology

authors： Walsh SL,June HL,Schuh KJ,Preston KL,Bigelow GE,Stitzer ML

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Caffeine has a well-established effect on reaction times (RTs) but the neurocognitive mechanisms underlying this are unclear. METHODS:In the present study, 15 female participants performed an oddball task after ingesting caffeine or a placebo, and electroencephalographic data were obtained. Single-trial P3b...

journal_title：Psychopharmacology

authors： Saville CWN,de Morree HM,Dundon NM,Marcora SM,Klein C

更新日期：2018-03-01 00:00:00

abstract：:Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect...

journal_title：Psychopharmacology

authors： Ennaceur A,Delacour J

更新日期：1987-01-01 00:00:00

abstract：:Red blood cell (RBC) glycine levels were examined in 27 bipolar patients, treated with lithium carbonate for a minimum of 8 months, who were either hypomanic, depressed, or euthymic in their mood. We found no difference in the RBC glycine or in the RBC: plasma glycine ratio between the hypomanic, depressed, or euthymi...

journal_title：Psychopharmacology

authors： Peselow ED,Deutsch SI,Stanley M,Banay-Schwartz M,Virgilio J,Fieve RR

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To compare matched paliperidone-ER- and olanzapine-treated schizophrenic patients on measures of glucose and lipid metabolism. METHODS:Eighty hospitalized patients with schizophrenia (DSM-IV) were randomly assigned to treatment with paliperidone ER or olanzapine for a period of 12 weeks. At baseline and ever...

journal_title：Psychopharmacology

authors： Hu S,Yao M,Peterson BS,Xu D,Hu J,Tang J,Fan B,Liao Z,Yuan T,Li Y,Yue W,Wei N,Zhou W,Huang M,Xu Y

更新日期：2013-11-01 00:00:00

abstract：:In a one-trial step-through passive avoidance task, pretraining administration of ethanol was shown to decrease the latencies to step through at both training (day 1) and testing (day 2) for both rats and mice. A detailed analysis of these effects showed that they differed from those reported previously by others. The...

journal_title：Psychopharmacology

authors： Bammer G,Chesher GB

更新日期：1982-01-01 00:00:00

abstract：:The effects of intraperitoneal administrations of the deoxycorticosterone metabolite, 5 alpha-pregnane-, 21 diol-20-one (3 alpha, 5 alpha-tetrahydrodeoxycorticosterone; alpha-THDOC) on the responses to aggression and defeat-induced analgesia were examined in subordinate intruder male mice in "resident-intruder" pairin...

journal_title：Psychopharmacology

authors： Kavaliers M

更新日期：1988-01-01 00:00:00

abstract：:Twenty-nine subjects performed a reaction time task with four levels of choice-task complexity under non-smoking, sham smoking, and low, medium and high nicotine cigarette conditions. Nicotine reduced decision time, while sham smoking increased decision time. This effect was independent of subjects' habitual levels of...

journal_title：Psychopharmacology

authors： Bates T,Pellett O,Stough C,Mangan G

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...

journal_title：Psychopharmacology

authors： Langleben DD,Busch EL,O'Brien CP,Elman I

更新日期：2012-04-01 00:00:00

abstract：RATIONALE:The endogenous opioid system has been implicated in substance abuse and response to pharmacotherapies for nicotine and alcohol addiction. We examined (1) the association of the functional OPRM1 A118G variant with the relative reinforcing value of nicotine and (2) the main and interacting effects of the mu-opi...

journal_title：Psychopharmacology

authors： Ray R,Jepson C,Patterson F,Strasser A,Rukstalis M,Perkins K,Lynch KG,O'Malley S,Berrettini WH,Lerman C

更新日期：2006-10-01 00:00:00

abstract：:The relationship between changes in IV tyramine pressor sensitivity accompanying selective monoamine oxidase (MAO) inhibitor treatment and estimates of MAO-A and MAO-B inhibition in vivo were studied. Reductions in platelet MAO activity provided an index of MAO-B inhibition, while changes in plasma 3-methoxy-4-hydroxy...

journal_title：Psychopharmacology

authors： Pickar D,Cohen RM,Jimerson DC,Lake CR,Murphy DL

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...

journal_title：Psychopharmacology

authors： Albelda N,Bar-On N,Joel D

更新日期：2010-05-01 00:00:00

abstract：RATIONALE:Partial dopamine receptor agonists have been proposed as candidate pharmacotherapies for cocaine dependence. OBJECTIVE:This 42-day, within-subject, human laboratory study assessed how maintenance on aripiprazole, a partial D(2) receptor agonist, influenced smoked cocaine self-administration, cardiovascular m...

journal_title：Psychopharmacology

authors： Haney M,Rubin E,Foltin RW

更新日期：2011-08-01 00:00:00

abstract：RATIONALE:The dopaminergic system, particularly D2-like dopamine receptors, has been strongly implicated in reward processing. Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes remain largely unexplored in humans. OBJECTIVES:To evaluate the effect...

journal_title：Psychopharmacology

authors： Pizzagalli DA,Evins AE,Schetter EC,Frank MJ,Pajtas PE,Santesso DL,Culhane M

更新日期：2008-02-01 00:00:00

abstract：:Five elderly depressed patients were treated with amitriptyline (AT) and nortriptyline (NT) in turn, in a cross-over design. Steady-state plasma drug levels were compared with those calculated for eight healthy subjects of previous single-dose studies. Plasma clearances were on average about 2.5 times lower in the pat...

journal_title：Psychopharmacology

authors： Burch JE

更新日期：1983-01-01 00:00:00

abstract：:The conditioned place preference technique was used to assess the affective properties of the direct dopamine D1 agonist, SKF38393, and the direct D2 agonist, LY171555 (quinpirole). A three compartment apparatus was used: the animals' pre-experimental preference for the two choice compartments was equal and, within ea...

journal_title：Psychopharmacology

authors： White NM,Packard MG,Hiroi N

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...

journal_title：Psychopharmacology

authors： Breslin FJ,Johnson BA,Lynch WJ

更新日期：2010-01-01 00:00:00

abstract：:In a double-blind comparison of haloperidol decanoate and fluphenazine decanoate given 4-weekly for 60 weeks as maintenance therapy in 38 chronic schizophrenic in-patients, plasma haloperidol, fluphenazine and prolactin levels were measured at regular intervals by radioimmunoassay. After the first injection, the mean ...

journal_title：Psychopharmacology

authors： Wiles DH,McCreadie RG,Whitehead A

更新日期：1990-01-01 00:00:00

abstract：:Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anx...

journal_title：Psychopharmacology

authors： Gerlach J,Christensen JK,Christensen TL,Elley J,Jensen JP,Larsen SB

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period cou...

journal_title：Psychopharmacology

authors： Byrnes JJ,Johnson NL,Carini LM,Byrnes EM

更新日期：2013-05-01 00:00:00

abstract：RATIONALE:H(3)-receptor inverse agonists raise a great interest as innovative therapeutics in several central disorders. Whereas their procognitive properties are well established, their antipsychotic-like properties are still debated. OBJECTIVES:We further explored the effect of maximal doses (3-10 mg/kg) of ciproxif...

journal_title：Psychopharmacology

authors： Burban A,Sadakhom C,Dumoulin D,Rose C,Le Pen G,Frances H,Arrang JM

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. OBJECTIVES:This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administer...

journal_title：Psychopharmacology

authors： Griffiths RR,Richards WA,McCann U,Jesse R

更新日期：2006-08-01 00:00:00

abstract：RATIONALE:Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear. OBJECTIVE:The present study examined the effect of pharmacological activation or blockade of the cannabinoid CB1 receptors on behavioral flexibility usi...

journal_title：Psychopharmacology

authors： Hill MN,Froese LM,Morrish AC,Sun JC,Floresco SB

更新日期：2006-08-01 00:00:00