Abstract:
BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a randomized and double-blind administration at five different sucrose concentrations ranging from 0.05 to 0.83 M. METHODS:The STT and cue-induced craving procedure were administered to opioid-dependent patients (n = 15) before and 1 week after the injection of a long-acting depot naltrexone (XRNT) preparation. RESULTS:Analyses of covariance, employing sucrose concentration and its perceived taste as covariates, showed that XRNT therapy significantly reduced the self-reported hedonic and motivational characteristics of sucrose. Greater reductions in both these characteristics were associated with more diminution in the cue-induced opioid craving. CONCLUSIONS:Opioid antagonism in opioid-dependent subjects leads to a smaller sweet taste reward, which, in turn, may be proportional to decreased opioid craving. These pilot results support the heuristic value of the STT as a potential marker of the XRNT treatment response and call for further inquiry into potential clinical applications of the test.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Langleben DD,Busch EL,O'Brien CP,Elman Idoi
10.1007/s00213-011-2503-1subject
Has Abstractpub_date
2012-04-01 00:00:00pages
559-64issue
3eissn
0033-3158issn
1432-2072journal_volume
220pub_type
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